Quantitative Proteomics Reveals that miR-155 Regulates the PI3K-AKT Pathway in Diffuse Large B-Cell Lymphoma

• Published in: The American journal of pathology Vol. 181; no. 1; pp. 26 - 33
• Main Authors: Huang, Xin, Shen, Yulei, Liu, Miao, Bi, Chengfeng, Jiang, Chunsun, Iqbal, Javeed, McKeithan, Timothy W, Chan, Wing C, Ding, Shi-Jian, Fu, Kai
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2012; American Society for Investigative Pathology
• Subjects: 3' Untranslated Regions - genetics; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Lymphoma, Large B-Cell, Diffuse - genetics; Lymphoma, Large B-Cell, Diffuse - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; MicroRNAs - physiology; Pathology; Phosphatidylinositol 3-Kinase - genetics; Phosphatidylinositol 3-Kinase - metabolism; Proteomics - methods; Proto-Oncogene Proteins c-akt - metabolism; RNA, Neoplasm - genetics; Short Communication; Signal Transduction - genetics; Transcription, Genetic

The aberrant expression of microRNA-155 (miR-155), which has emerged as having a significant impact on the biological characteristics of lymphocytes, plays important roles in B-cell malignancies, such as diffuse large B-cell lymphoma (DLBCL). DLBCL is the most common non–Hodgkin's lymphoma in t...