A Multicenter Study to Evaluate Harmonization of Assays for C-Terminal Telopeptides of Type I Collagen (ß-CTX): A Report from the IFCC-IOF Committee for Bone Metabolism (C-BM)

• Published in: Calcified tissue international Vol. 108; no. 6; pp. 785 - 797
• Main Authors: Cavalier, E., Eastell, R., Jørgensen, N. R., Makris, K., Tournis, S., Vasikaran, S., Kanis, J. A., Cooper, C., Pottel, H., Morris, H. A.
• Format: Journal Article Web Resource
• Language: English
• Published: New York Springer US 01.06.2021; Springer Nature B.V; Springer
• Subjects: Biochemistry; Biomarkers; Biomedical and Life Sciences; Bone Remodeling; Bone Resorption; Bone turnover; Bone turnover markers; C-terminal telopeptide of type I collagen; Cell Biology; Clinical trials; Collagen Type I; Edetic acid; Endocrinology; Enzyme-linked immunosorbent assay; Generalized linear models; Harmonization; Human health sciences; Humans; Laboratory medicine & medical technology; Life Sciences; Medical laboratories; Médecine de laboratoire & technologie médicale; Original Research; Orthopedics; Osteoporosis; Peptide Fragments; Peptides; Plasma; Sciences de la santé humaine; ß-crosslaps; ß-CTX; C-terminal telopeptide of type I collagen; Bone resorption; ß-CTX; Bone turnover markers; ß-crosslaps; Harmonization

Background Biochemical bone turnover markers are useful tools to assess bone remodeling. C-terminal telopeptide of type I collagen (ß-CTX) has been recommended as a reference marker for bone resorption in research studies. Methods We describe the results of a multicenter study for routine clinical l...