Bolus infusion scheme for the adjustment of steady state [11C]Flumazenil levels in the grey matter and in the blood plasma for neuroreceptor imaging

• Published in: NeuroImage (Orlando, Fla.) Vol. 221; p. 117160
• Main Authors: Mauler, Jörg, Heinzel, Alexander, Matusch, Andreas, Herzog, Hans, Neuner, Irene, Scheins, Jürgen, Wyss, Christine, Dammers, Jürgen, Lang, Markus, Ermert, Johannes, Neumaier, Bernd, Langen, Karl-Josef, Shah, N. Jon
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2020; Elsevier Limited; Elsevier
• Subjects: [11C]flumazenil; Adult; Binding sites; Blood flow; Bolus infusion scheme; Brain; Carbon Radioisotopes - administration & dosage; Decomposition; Experiments; Flumazenil; Flumazenil - administration & dosage; Flumazenil - blood; Flumazenil - pharmacokinetics; GABA Modulators - administration & dosage; GABA Modulators - blood; GABA Modulators - pharmacokinetics; Gray Matter - diagnostic imaging; Gray Matter - drug effects; Gray Matter - metabolism; Humans; Ligands; Magnetic Resonance Imaging; Male; Metabolic rate; Metabolite analysis; Metabolites; Multimodal Imaging; Neuroimaging; Partial volume correction; PET/MR; Plasma; Positron emission tomography; Sensory Receptor Cells - drug effects; Sensory Receptor Cells - metabolism; Signal processing; Steady state; Substantia alba; Substantia grisea; Volunteers; White Matter - diagnostic imaging; White Matter - drug effects; White Matter - metabolism; Young Adult; [11C]flumazenil; Partial volume correction; PET/MR; Bolus infusion scheme; Metabolite analysis; Steady state; [C]flumazenil

The use of hybrid PET/MR imaging facilitates the simultaneous investigation of challenge-related changes in ligand binding to neuroreceptors using PET, while concurrently measuring neuroactivation or blood flow with MRI. Having attained a steady state of the PET radiotracer using a bolus-infusion pr...