Innate immune activation in neutrophilic asthma and bronchiectasis

• Published in: Thorax Vol. 62; no. 3; pp. 211 - 218
• Main Authors: SIMPSON, Jodie L, GRISSELL, Terry V, DOUWES, Jeroen, SCOTT, Rodney J, BOYLE, Michael J, GIBSON, Peter G
• Format: Journal Article
• Language: English
• Published: London BMJ 01.03.2007; BMJ Group
• Subjects: Adult; Aged; Asthma; Asthma - immunology; Biological and medical sciences; Bronchiectasis - immunology; Chronic obstructive pulmonary disease, asthma; Cross-Sectional Studies; Endotoxins - metabolism; Eosinophils - immunology; Female; Humans; Immunity, Cellular; Interleukin-8 - metabolism; Male; Medical sciences; Middle Aged; Pneumology; Respiratory system : syndromes and miscellaneous diseases; RNA, Messenger - metabolism; Toll-Like Receptors - immunology; Lung disease; Respiratory disease; Bronchus disease; Cardiovascular disease; Activation; Bronchiectasis; Obstructive pulmonary disease; Asthma

The role of the innate immune system in the pathogenesis of asthma is unclear. Activation of innate immune receptors in response to bacterial lipopolysaccharide, viral infection and particulate matter triggers a pre-programmed inflammatory response, which involves interleukin (IL)8 and neutrophil in...