Mechanistic manifold in a hemoprotein-catalyzed cyclopropanation reaction with diazoketone

• Published in: Nature communications Vol. 14; no. 1; p. 7985
• Main Authors: Nam, Donggeon, Bacik, John-Paul, Khade, Rahul L., Aguilera, Maria Camila, Wei, Yang, Villada, Juan D., Neidig, Michael L., Zhang, Yong, Ando, Nozomi, Fasan, Rudi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.12.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 119/118; 45/22; 631/45/603; 639/638/77/885; 639/638/92/173; 82/80; 82/83; Biocatalysts; Carbenes; Chemical reactions; Computer applications; Crystallography; Heme; Humanities and Social Sciences; Manifolds; Mossbauer spectroscopy; multidisciplinary; Myoglobins; Reaction kinetics; Science; Science (multidisciplinary); Software; X-ray crystallography

Hemoproteins have recently emerged as promising biocatalysts for new-to-nature carbene transfer reactions. However, mechanistic understanding of the interplay between productive and unproductive pathways in these processes is limited. Using spectroscopic, structural, and computational methods, we in...