Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection

• Published in: Nature communications Vol. 15; no. 1; pp. 7461 - 18
• Main Authors: Dias, Joana, Fabozzi, Giulia, Fourati, Slim, Chen, Xuejun, Liu, Cuiping, Ambrozak, David R., Ransier, Amy, Laboune, Farida, Hu, Jianfei, Shi, Wei, March, Kylie, Maximova, Anna A., Schmidt, Stephen D., Samsel, Jakob, Talana, Chloe A., Ernste, Keenan, Ko, Sung Hee, Lucas, Margaret E., Radecki, Pierce E., Boswell, Kristin L., Nishimura, Yoshiaki, Todd, John-Paul, Martin, Malcolm A., Petrovas, Constantinos, Boritz, Eli A., Doria-Rose, Nicole A., Douek, Daniel C., Sékaly, Rafick-Pierre, Lifson, Jeffrey D., Asokan, Mangaiarkarasi, Gama, Lucio, Mascola, John R., Pegu, Amarendra, Koup, Richard A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.08.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/106; 13/31; 14/19; 14/63; 38/91; 45/90; 631/250/2152/2153/1291; 631/250/2520; 692/308/2778; 692/699/255/1901; Affinity; Antibodies; Antiviral agents; Antiviral drugs; Binding; CD69 antigen; CD8 antigen; Cell-mediated immunity; Chronic infection; Down-regulation; Fc receptors; HIV; Human immunodeficiency virus; Humanities and Social Sciences; Immunology; Infections; Lymph nodes; Lymphocytes; Lymphocytes T; Monkeys; Monoclonal antibodies; Monocytes; multidisciplinary; Mutation; Neutralization; Neutralizing; NF-κB protein; Receptors; Science; Science (multidisciplinary); Shape effects; Viruses; γ-Interferon

Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating virus neutralization and antiviral effector functions through their Fab and Fc domains, respectively. So far, bNAbs with enhanced Fc effector functions in vitro have only been tested in NHPs during chronic simian...