The clathrin adaptor complex-1 and Rab12 regulate post-golgi trafficking of WT epidermal growth factor receptor (EGFR)

• Published in: The Journal of biological chemistry Vol. 299; no. 3; p. 102979
• Main Authors: Wang, Jinhui, Lau, Pik Ki, Li, Chun Wa, Guo, Yusong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2023; American Society for Biochemistry and Molecular Biology
• Subjects: Adaptor Protein Complex 1 - genetics; Adaptor Protein Complex 1 - metabolism; cargo sorting; clathrin adaptor complex-1; EGFR; ErbB Receptors - genetics; ErbB Receptors - metabolism; Golgi Apparatus - metabolism; Humans; Protein Transport; rab GTP-Binding Proteins - genetics; rab GTP-Binding Proteins - metabolism; Rab12; trans-Golgi network; trans-Golgi Network - genetics; trans-Golgi Network - metabolism; SBP; cargo sorting; Rab12; EGF; DAPI; WB; EGFP; AP-1; ER; EGFR; trans-Golgi network; CT; clathrin adaptor complex-1; pEGFR; FBS; KD; TGN; RT-qPCR; RUSH

The epidermal growth factor receptor (EGFR) plays important roles in cancer progression and is one of the major drug targets for targeted cancer therapy. Although fundamentally important, how newly synthesized EGFR is delivered to the cell surface to perform its cellular functions remains to be furt...