Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate

• Published in: European archives of psychiatry and clinical neuroscience Vol. 264; no. 2; pp. 179 - 183
• Main Authors: Fond, Guillaume, Macgregor, Alexandra, Tamouza, Ryad, Hamdani, Nora, Meary, Alexandre, Leboyer, Marion, Dubremetz, Jean-Francois
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2014; Springer Nature B.V; Springer Verlag
• Subjects: Antiprotozoal Agents - therapeutic use; Antipsychotic Agents - therapeutic use; Dose-Response Relationship, Drug; Female; Human health and pathology; Humans; Life Sciences; Male; Medicine; Medicine & Public Health; Neurosciences; Psychiatrics and mental health; Psychiatry; Schizophrenia - drug therapy; Short Communication; Toxoplasmosis; Valproic Acid - therapeutic use; Schizophrenia; Antipsychotic; Mood stabilizer; Calmodulin; Phenothiazine; phenothiazine; antipsychotic; Toxoplasma gondii; mood stabiliser; schizophrenia; calmodulin

Recent studies have shown a strong link between Toxoplasma gondii infection and psychiatric disorders, especially schizophrenia and bipolar disorders (odd ratio ≈2.7 for each disorder). Antipsychotic drugs and mood stabilizers may have anti-toxoplasmic activity that potentially may be associated wit...