Calocedrus formosana Essential Oils Induce ROS-Mediated Autophagy and Apoptosis by Targeting SIRT1 in Colon Cancer Cells

• Published in: Antioxidants Vol. 13; no. 3; p. 284
• Main Authors: Islam, Atikul, Chang, Yu-Chun, Tsao, Nai-Wen, Wang, Sheng-Yang, Chueh, Pin Ju
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.02.2024; MDPI
• Subjects: Acetylation; Acetylcysteine; Antibodies; antineoplastic agents; Antineoplastic drugs; Apoptosis; Autophagy; c-Myc protein; Calocedrus; Calocedrus formosana; Cancer therapies; Caspase-3; Caspase-9; Cell death; Cell growth; Cell proliferation; Chemoresistance; Chromatography; Colon cancer; Colorectal cancer; Colorectal carcinoma; colorectal neoplasms; cysteine; Essential oils; Flow cytometry; Homeostasis; Mass spectrometry; Molecular modelling; mutants; Myc protein; Null cells; Oils & fats; p53 Protein; prognosis; reactive oxygen species (ROS); Scientific imaging; SIRT1 protein; United Kingdom > UK; United States > US; Taiwan; autophagy; colorectal cancer; Calocedrus formosana; silent mating type information regulation 2 homolog 1 (SIRT1); apoptosis; reactive oxygen species (ROS); essential oils

Colorectal cancer is the most common cancer that affects both sexes and has a poor prognosis due to aggressiveness and chemoresistance. Essential oils isolated from Calocedrus formosana (CF-EOs) have been shown to demonstrate anti-termite, antifungal, anti-mosquito, and anti-microbial activities. Ho...