The varied influence of ocular Demodex infestation on dry eye disease and meibomian gland dysfunction across different age groups
This study aimed to investigate the impact of ocular demodicosis on dry eye disease (DED) and meibomian gland dysfunction (MGD) across different age populations: young (20 to < 40), middle-aged (40 to < 60), and elderly (≥ 60), based on the retrospective medical chart review. In each age subgr...
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| Published in | Scientific reports Vol. 13; no. 1; pp. 16324 - 10 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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28.09.2023
Nature Publishing Group Nature Portfolio |
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| Abstract | This study aimed to investigate the impact of ocular demodicosis on dry eye disease (DED) and meibomian gland dysfunction (MGD) across different age populations: young (20 to < 40), middle-aged (40 to < 60), and elderly (≥ 60), based on the retrospective medical chart review. In each age subgroup,
Demodex
infestation and its count were correlated with clinical parameters of DED and MGD. Among the total of 351 subjects, 52.7% had ocular demodicosis, with a mean of 2.31 ± 1.39 mites per four eyelashes (0.58 per lash) in a unilateral eye. In the age subgroup 1 (age < 40; N = 44), subjects with
Demodex
had significantly higher meibum quality grades. In subgroup 2 (40 ≤ age < 60; N = 122), subjects with
Demodex
had higher ocular surface disease index scores and higher MG expressibility grades. However, in subgroup 3 (age ≥ 60; N = 185), demographics and all parameters did not differ according to
Demodex
infestation. Moreover, the number of mites did not correlate with MGD severity in any of the subgroups. In conclusion, age may act as a significant confounding factor in the relationship between ocular
Demodex
infestation and clinical features of DED and MGD, despite older patients aged 60 years and above being at a higher risk of
Demodex
infestation and experiencing more severe MGD. |
|---|---|
| AbstractList | This study aimed to investigate the impact of ocular demodicosis on dry eye disease (DED) and meibomian gland dysfunction (MGD) across different age populations: young (20 to < 40), middle-aged (40 to < 60), and elderly (≥ 60), based on the retrospective medical chart review. In each age subgroup,
Demodex
infestation and its count were correlated with clinical parameters of DED and MGD. Among the total of 351 subjects, 52.7% had ocular demodicosis, with a mean of 2.31 ± 1.39 mites per four eyelashes (0.58 per lash) in a unilateral eye. In the age subgroup 1 (age < 40; N = 44), subjects with
Demodex
had significantly higher meibum quality grades. In subgroup 2 (40 ≤ age < 60; N = 122), subjects with
Demodex
had higher ocular surface disease index scores and higher MG expressibility grades. However, in subgroup 3 (age ≥ 60; N = 185), demographics and all parameters did not differ according to
Demodex
infestation. Moreover, the number of mites did not correlate with MGD severity in any of the subgroups. In conclusion, age may act as a significant confounding factor in the relationship between ocular
Demodex
infestation and clinical features of DED and MGD, despite older patients aged 60 years and above being at a higher risk of
Demodex
infestation and experiencing more severe MGD. This study aimed to investigate the impact of ocular demodicosis on dry eye disease (DED) and meibomian gland dysfunction (MGD) across different age populations: young (20 to < 40), middle-aged (40 to < 60), and elderly (≥ 60), based on the retrospective medical chart review. In each age subgroup, Demodex infestation and its count were correlated with clinical parameters of DED and MGD. Among the total of 351 subjects, 52.7% had ocular demodicosis, with a mean of 2.31 ± 1.39 mites per four eyelashes (0.58 per lash) in a unilateral eye. In the age subgroup 1 (age < 40; N = 44), subjects with Demodex had significantly higher meibum quality grades. In subgroup 2 (40 ≤ age < 60; N = 122), subjects with Demodex had higher ocular surface disease index scores and higher MG expressibility grades. However, in subgroup 3 (age ≥ 60; N = 185), demographics and all parameters did not differ according to Demodex infestation. Moreover, the number of mites did not correlate with MGD severity in any of the subgroups. In conclusion, age may act as a significant confounding factor in the relationship between ocular Demodex infestation and clinical features of DED and MGD, despite older patients aged 60 years and above being at a higher risk of Demodex infestation and experiencing more severe MGD. This study aimed to investigate the impact of ocular demodicosis on dry eye disease (DED) and meibomian gland dysfunction (MGD) across different age populations: young (20 to < 40), middle-aged (40 to < 60), and elderly (≥ 60), based on the retrospective medical chart review. In each age subgroup, Demodex infestation and its count were correlated with clinical parameters of DED and MGD. Among the total of 351 subjects, 52.7% had ocular demodicosis, with a mean of 2.31 ± 1.39 mites per four eyelashes (0.58 per lash) in a unilateral eye. In the age subgroup 1 (age < 40; N = 44), subjects with Demodex had significantly higher meibum quality grades. In subgroup 2 (40 ≤ age < 60; N = 122), subjects with Demodex had higher ocular surface disease index scores and higher MG expressibility grades. However, in subgroup 3 (age ≥ 60; N = 185), demographics and all parameters did not differ according to Demodex infestation. Moreover, the number of mites did not correlate with MGD severity in any of the subgroups. In conclusion, age may act as a significant confounding factor in the relationship between ocular Demodex infestation and clinical features of DED and MGD, despite older patients aged 60 years and above being at a higher risk of Demodex infestation and experiencing more severe MGD.This study aimed to investigate the impact of ocular demodicosis on dry eye disease (DED) and meibomian gland dysfunction (MGD) across different age populations: young (20 to < 40), middle-aged (40 to < 60), and elderly (≥ 60), based on the retrospective medical chart review. In each age subgroup, Demodex infestation and its count were correlated with clinical parameters of DED and MGD. Among the total of 351 subjects, 52.7% had ocular demodicosis, with a mean of 2.31 ± 1.39 mites per four eyelashes (0.58 per lash) in a unilateral eye. In the age subgroup 1 (age < 40; N = 44), subjects with Demodex had significantly higher meibum quality grades. In subgroup 2 (40 ≤ age < 60; N = 122), subjects with Demodex had higher ocular surface disease index scores and higher MG expressibility grades. However, in subgroup 3 (age ≥ 60; N = 185), demographics and all parameters did not differ according to Demodex infestation. Moreover, the number of mites did not correlate with MGD severity in any of the subgroups. In conclusion, age may act as a significant confounding factor in the relationship between ocular Demodex infestation and clinical features of DED and MGD, despite older patients aged 60 years and above being at a higher risk of Demodex infestation and experiencing more severe MGD. Abstract This study aimed to investigate the impact of ocular demodicosis on dry eye disease (DED) and meibomian gland dysfunction (MGD) across different age populations: young (20 to < 40), middle-aged (40 to < 60), and elderly (≥ 60), based on the retrospective medical chart review. In each age subgroup, Demodex infestation and its count were correlated with clinical parameters of DED and MGD. Among the total of 351 subjects, 52.7% had ocular demodicosis, with a mean of 2.31 ± 1.39 mites per four eyelashes (0.58 per lash) in a unilateral eye. In the age subgroup 1 (age < 40; N = 44), subjects with Demodex had significantly higher meibum quality grades. In subgroup 2 (40 ≤ age < 60; N = 122), subjects with Demodex had higher ocular surface disease index scores and higher MG expressibility grades. However, in subgroup 3 (age ≥ 60; N = 185), demographics and all parameters did not differ according to Demodex infestation. Moreover, the number of mites did not correlate with MGD severity in any of the subgroups. In conclusion, age may act as a significant confounding factor in the relationship between ocular Demodex infestation and clinical features of DED and MGD, despite older patients aged 60 years and above being at a higher risk of Demodex infestation and experiencing more severe MGD. |
| ArticleNumber | 16324 |
| Author | Chun, Yeoun Sook Lee, Seung Hyeun Lee, Won Jun Kim, Minjeong Kim, Kyoung Woo |
| Author_xml | – sequence: 1 givenname: Won Jun surname: Lee fullname: Lee, Won Jun organization: Department of Ophthalmology, Chung-Ang University College of Medicine, Chung-Ang University Hospital – sequence: 2 givenname: Minjeong surname: Kim fullname: Kim, Minjeong organization: Department of Ophthalmology, Chung-Ang University College of Medicine, Chung-Ang University Hospital – sequence: 3 givenname: Seung Hyeun surname: Lee fullname: Lee, Seung Hyeun organization: Department of Ophthalmology, Chung-Ang University College of Medicine, Chung-Ang University Hospital – sequence: 4 givenname: Yeoun Sook surname: Chun fullname: Chun, Yeoun Sook organization: Department of Ophthalmology, Chung-Ang University College of Medicine, Chung-Ang University Hospital – sequence: 5 givenname: Kyoung Woo surname: Kim fullname: Kim, Kyoung Woo email: kkanssa@cau.ac.kr organization: Department of Ophthalmology, Chung-Ang University College of Medicine, Chung-Ang University Hospital, Biomedical Research Institute, Chung-Ang University Hospital |
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| Cites_doi | 10.1136/bjophthalmol-2017-310302 10.3389/fmed.2022.833778 10.1001/archopht.118.5.615 10.1016/j.jcjo.2015.05.007 10.4103/ijo.IJO_3641_20 10.1016/j.jtos.2017.05.003 10.1007/s11745-007-3080-2 10.1016/j.ajo.2019.03.007 10.1016/j.ajo.2013.09.031 10.1167/iovs.10-6997b 10.1016/j.ajo.2017.05.022 10.1097/ICO.0000000000002542 10.1007/s13238-017-0395-5 10.1001/jamaophthalmol.2013.561 10.1167/tvst.10.14.6 10.1016/j.ajo.2019.02.024 10.1097/ICO.0000000000002148 10.3346/jkms.2012.27.12.1574 10.1186/s12886-022-02610-9 10.1167/iovs.10-6997f 10.1016/0002-9394(81)90291-9 10.5114/aoms.2016.60663 10.1097/IIO.0000000000000170 10.1038/s41598-021-87336-2 10.1001/archophthalmol.2009.356 10.1080/092865805910057 10.1016/j.jtos.2013.05.003 10.1097/ICO.0000000000001361 10.1111/opo.12691 10.1097/ICL.0000000000000640 10.1038/s41598-022-06191-x 10.1016/j.ajo.2009.09.013 10.1167/iovs.05-0275 10.1038/s41598-021-92020-6 10.1038/s41433-023-02500-4 |
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| Title | The varied influence of ocular Demodex infestation on dry eye disease and meibomian gland dysfunction across different age groups |
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