Understanding and leveraging phenotypic plasticity during metastasis formation

• Published in: NPJ systems biology and applications Vol. 9; no. 1; pp. 48 - 11
• Main Authors: Shah, Saumil, Philipp, Lisa-Marie, Giaimo, Stefano, Sebens, Susanne, Traulsen, Arne, Raatz, Michael
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/158/1745; 631/553/2393; 631/67; Bioinformatics; Biomedical and Life Sciences; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Immunotherapy; Life Sciences; Mathematical models; Metastases; Metastasis; Phenotypes; Phenotypic plasticity; Systems Biology; Tumor cells; Tumors

Cancer metastasis is the process of detrimental systemic spread and the primary cause of cancer-related fatalities. Successful metastasis formation requires tumor cells to be proliferative and invasive; however, cells cannot be effective at both tasks simultaneously. Tumor cells compensate for this...