Cripto-1 Ablation Disrupts Alveolar Development in the Mouse Mammary Gland through a Progesterone Receptor–Mediated Pathway
Cripto-1, a member of the epidermal growth factor–Cripto-1/FRL-1/Cryptic family, is critical for early embryonic development. Together with its ligand Nodal, Cripto-1 has been found to be associated with the undifferentiated status of mouse and human embryonic stem cells. Several studies have clearl...
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Published in | The American journal of pathology Vol. 185; no. 11; pp. 2907 - 2922 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
Elsevier Inc
01.11.2015
American Society for Investigative Pathology |
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Abstract | Cripto-1, a member of the epidermal growth factor–Cripto-1/FRL-1/Cryptic family, is critical for early embryonic development. Together with its ligand Nodal, Cripto-1 has been found to be associated with the undifferentiated status of mouse and human embryonic stem cells. Several studies have clearly shown that Cripto-1 is involved in regulating branching morphogenesis and epithelial-mesenchymal transition of the mammary gland both in vitro and in vivo and together with the cofactor GRP78 is critical for the maintenance of mammary stem cells ex vivo . Our previous studies showed that mammary-specific overexpression of human Cripto-1 exhibited dramatic morphological alterations in nulliparous mice mammary glands. The present study shows a novel mechanism for Cripto-1 regulation of mammary gland development through direct effects on progesterone receptor expression and pathways regulated by progesterone in the mammary gland. We demonstrate a strict temporal regulation of mouse Cripto-1 (mCripto-1) expression that occurs during mammary gland development and a stage-specific function of mCripto-1 signaling during mammary gland development. Our data suggest that Cripto-1, like the progesterone receptor, is not required for the initial ductal growth but is essential for subsequent side branching and alveologenesis during the initial stages of pregnancy. Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-κB/receptor activator NF-κB ligand, and NF-κB signaling pathways. |
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AbstractList | Cripto-1, a member of the epidermal growth factor–Cripto-1/FRL-1/Cryptic family, is critical for early embryonic development. Together with its ligand Nodal, Cripto-1 has been found to be associated with the undifferentiated status of mouse and human embryonic stem cells. Several studies have clearly shown that Cripto-1 is involved in regulating branching morphogenesis and epithelial-mesenchymal transition of the mammary gland both in vitro and in vivo and together with the cofactor GRP78 is critical for the maintenance of mammary stem cells ex vivo . Our previous studies showed that mammary-specific overexpression of human Cripto-1 exhibited dramatic morphological alterations in nulliparous mice mammary glands. The present study shows a novel mechanism for Cripto-1 regulation of mammary gland development through direct effects on progesterone receptor expression and pathways regulated by progesterone in the mammary gland. We demonstrate a strict temporal regulation of mouse Cripto-1 (mCripto-1) expression that occurs during mammary gland development and a stage-specific function of mCripto-1 signaling during mammary gland development. Our data suggest that Cripto-1, like the progesterone receptor, is not required for the initial ductal growth but is essential for subsequent side branching and alveologenesis during the initial stages of pregnancy. Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-κB/receptor activator NF-κB ligand, and NF-κB signaling pathways. Cripto-1, a member of the epidermal growth factor–Cripto-1/FRL-1/Cryptic family, is critical for early embryonic development. Together with its ligand Nodal, Cripto-1 has been found to be associated with the undifferentiated status of mouse and human embryonic stem cells. Several studies have clearly shown that Cripto-1 is involved in regulating branching morphogenesis and epithelial-mesenchymal transition of the mammary gland both in vitro and in vivo and together with the cofactor GRP78 is critical for the maintenance of mammary stem cells ex vivo . Our previous studies showed that mammary-specific overexpression of human Cripto-1 exhibited dramatic morphological alterations in nulliparous mice mammary glands. The present study shows a novel mechanism for Cripto-1 regulation of mammary gland development through direct effects on progesterone receptor expression and pathways regulated by progesterone in the mammary gland. We demonstrate a strict temporal regulation of mouse Cripto-1 (mCripto-1) expression that occurs during mammary gland development and a stage-specific function of mCripto-1 signaling during mammary gland development. Our data suggest that Cripto-1, like the progesterone receptor, is not required for the initial ductal growth but is essential for subsequent side branching and alveologenesis during the initial stages of pregnancy. Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-κB/receptor activator NF-κB ligand, and NF-κB signaling pathways. |
Author | Raafat, Ahmed Rangel, Maria Cristina Klauzinska, Malgorzata Bertolette, Daniel Bianco, Caterina Callahan, Robert Salomon, David S Shen, Michael M Gonzales, Monica McCurdy, David Vaidyanath, Arun Castro, Nadia P |
AuthorAffiliation | Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland Departments of Medicine Genetics and Development, Urology, and Systems Biology, Columbia University Medical Center, New York, New York |
AuthorAffiliation_xml | – name: Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland – name: Departments of Medicine Genetics and Development, Urology, and Systems Biology, Columbia University Medical Center, New York, New York – name: Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland |
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Cites_doi | 10.1038/sj.onc.1208159 10.2353/ajpath.2010.100102 10.1210/endo-95-5-1486 10.1242/dev.00859 10.1210/me.2013-1077 10.1016/S0021-9258(19)38400-5 10.1186/bcr1411 10.1002/stem.1112 10.1073/pnas.0307864100 10.1006/excr.2001.5195 10.1074/jbc.M707492200 10.1016/S0021-9258(19)61999-X 10.1016/j.stemcr.2014.02.010 10.1023/A:1013063514007 10.1038/sj.onc.1209823 10.1016/S0960-0760(01)00182-0 10.1023/A:1018766000275 10.1038/nbt.1503 10.1093/nar/25.21.4323 10.1073/pnas.0706933104 10.1016/j.stem.2011.07.016 10.1002/jcp.22526 10.1002/jcb.21475 10.3748/wjg.v16.i5.571 10.1016/S0021-9258(18)55158-9 10.1002/(SICI)1098-2744(199601)15:1<44::AID-MC7>3.0.CO;2-S 10.1101/gad.242511.114 10.1002/jcp.21462 10.1210/me.2010-0423 10.3389/fcell.2015.00031 10.1126/scitranslmed.3005654 10.15252/embj.201490434 10.1016/j.ajpath.2012.02.031 10.1038/onc.2008.379 10.1016/j.cellsig.2012.09.024 10.1038/nature04524 10.1016/j.semcancer.2014.08.003 10.1016/S0002-9440(10)63000-3 10.1080/gye.17.2.169.176 10.1007/s10911-007-9035-7 10.1002/1097-4652(2001)9999:9999<::AID-JCP1056>3.0.CO;2-0 10.1038/nature09495 10.1073/pnas.95.9.5076 10.1101/gad.9.18.2266 10.1126/science.1154884 10.1038/sj.onc.1209954 10.1371/journal.pone.0043624 10.1038/36593 10.1530/rep.0.1250143 10.1186/bcr1653 10.1242/dev.129.6.1377 10.1186/bcr1368 10.1038/sj.onc.1208417 10.1242/dev.118.4.1157 10.1016/S0092-8674(00)00103-3 10.1186/bcr1848 10.1007/s10911-006-9026-0 10.1073/pnas.0915148107 10.1242/dev.02157 10.1371/journal.pone.0029021 10.1016/S0070-2153(05)67003-2 10.1038/27215 10.1074/jbc.272.6.3330 10.1002/j.1460-2075.1993.tb05832.x 10.1002/jcp.20062 10.1007/0-306-46832-8_16 10.1093/carcin/bgm293 10.1016/j.ydbio.2010.07.001 10.1007/BF01806214 10.1210/endo.141.8.7609 10.1074/jbc.M606975200 10.1006/dbio.1995.1060 10.1016/j.bbrc.2007.01.143 10.1128/MCB.23.1.150-162.2003 10.1096/fj.10-157982 10.1152/physiolgenomics.00067.2002 |
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References | Wagner, Krempler, Qi, Park, Henry, Triplett, Riedlinger, Rucker, Hennighausen (bib16) 2003; 23 Mukherjee, Soyal, Li, Ying, He, DeMayo, Lydon (bib69) 2010; 24 Toualbi-Abed, Daniel, Guller, Legrand, Mauriz, Mauviel, Bernuau (bib40) 2008; 29 Raafat, Strizzi, Lashin, Ginsburg, McCurdy, Salomon, Smith, Medina, Callahan (bib19) 2012; 7 Miharada, Karlsson, Rehn, Rorby, Siva, Cammenga, Karlsson (bib8) 2011; 9 Obr, Grimm, Bishop, Pike, Lydon, Edwards (bib38) 2013; 27 Spike, Kelber, Booker, Kalathur, Rodewald, Lipianskaya, La, He, Wright, Klemke, Wahl, Gray (bib9) 2014; 2 Hofbauer, Rachner, Singh (bib35) 2008; 10 Hewitt, Korach (bib60) 2003; 125 Wagner, Boulanger, Henry, Sgagias, Hennighausen, Smith (bib22) 2002; 129 Gonzalez-Suarez, Jacob, Jones, Miller, Roudier-Meyer, Erwert, Pinkas, Branstetter, Dougall (bib71) 2010; 468 Raafat, Zoltan-Jones, Strizzi, Bargo, Kimura, Salomon, Callahan (bib21) 2007; 26 Anderson, Rudolph, McManaman, Neville (bib70) 2007; 9 Raafat, Li, Bennett, Hofseth, Haslam (bib28) 2001; 187 Jones, Nakashima, Sanchez, Kozieradzki, Komarova, Sarosi, Morony, Rubin, Sarao, Hojilla, Komnenovic, Kong, Schreiber, Dixon, Sims, Khokha, Wada, Penninger (bib36) 2006; 440 Clarke, Roman, Graham, Koga, Sutherland (bib65) 1990; 265 Wechselberger, Strizzi, Kenney, Hirota, Sun, Ebert, Orozco, Bianco, Khan, Wallace-Jones, Normanno, Adkins, Sanicola, Salomon (bib10) 2005; 24 Emmen, Korach (bib59) 2003; 17 Fata, Kong, Li, Sasaki, Irie-Sasaki, Moorehead, Elliott, Scully, Voura, Lacey, Boyle, Khokha, Penninger (bib37) 2000; 103 Tanos, Sflomos, Echeverria, Ayyanan, Gutierrez, Delaloye, Raffoul, Fiche, Dougall, Schneider, Yalcin-Ozuysal, Brisken (bib72) 2013; 5 Chapman, Lourenco, Tonner, Flint, Selbert, Takeda, Akira, Clarke, Watson (bib52) 2000; 480 Savouret, Rauch, Redeuilh, Sar, Chauchereau, Woodruff, Parker, Milgrom (bib67) 1994; 269 Wechselberger, Ebert, Bianco, Khan, Sun, Wallace-Jones, Montesano, Salomon (bib13) 2001; 266 Ding, Yang, Yan, Chen, Desai, Wynshaw-Boris, Shen (bib3) 1998; 395 Zhang, Zhao, Xin (bib56) 2010; 16 Jhappan, Geiser, Kordon, Bagheri, Hennighausen, Roberts, Smith, Merlino (bib44) 1993; 12 Aoi, Yae, Nakagawa, Ichisaka, Okita, Takahashi, Chiba, Yamanaka (bib7) 2008; 321 Hamada, Watanabe, Hirota, Bianco, Strizzi, Mancino, Gonzales, Salomon (bib76) 2007; 355 Wagner, Wall, St-Onge, Gruss, Wynshaw-Boris, Garrett, Li, Furth, Hennighausen (bib15) 1997; 25 Olsson, Jernstrom, Alm, Kreipe, Ingvar, Jonsson, Ryden (bib62) 1996; 40 Bianco, Rangel, Castro, Nagaoka, Rollman, Gonzales, Salomon (bib5) 2010; 177 Lydon, Ge, Kittrell, Medina, O'Malley (bib73) 1999; 59 Aasen, Raya, Barrero, Garreta, Consiglio, Gonzalez, Vassena, Bilic, Pekarik, Tiscornia, Edel, Boue, Izpisua Belmonte (bib6) 2008; 26 Feng, Manka, Wagner, Khan (bib23) 2007; 104 Hentschke, Kurth, Borgmeyer, Hubner (bib63) 2006; 281 Kannan, De Santis, Lohmeyer, Riese, Smith, Hynes, Seno, Brandt, Bianco, Persico, Kenney, Normanno, Martinez-Lacaci, Ciardiello, Stern, Gullick, Salomon (bib49) 1997; 272 Bockamp, Maringer, Spangenberg, Fees, Fraser, Eshkind, Oesch, Zabel (bib26) 2002; 11 Chu, Ding, Jeays-Ward, Price, Placzek, Shen (bib4) 2005; 132 Klauzinska, Castro, Rangel, Spike, Gray, Bertolette, Cuttitta, Salomon (bib1) 2014; 29 Cocolakis, Dai, Drevet, Ho, Haines, Ali, Lebrun (bib51) 2008; 283 Quesnelle, Boehm, Grandis (bib55) 2007; 102 Sun, Strizzi, Raafat, Hirota, Bianco, Feigenbaum, Kenney, Wechselberger, Callahan, Salomon (bib14) 2005; 167 Brisken, Rajaram (bib46) 2006; 11 Scribner, Wellberg, Metz, Porter (bib53) 2011; 25 Dono, Scalera, Pacifico, Acampora, Persico, Simeone (bib64) 1993; 118 Lydon, DeMayo, Funk, Mani, Hughes, Montgomery, Shyamala, Conneely, O'Malley (bib31) 1995; 9 Yin, Roqueiro, Huang, Owen, Xie, Navarro, Monsivais, Coon, Kim, Dai, Bulun (bib34) 2012; 7 Gilmore (bib41) 2006; 25 Lieberman, Bona, Edwards, Nordeen (bib33) 1993; 7 Silva (bib54) 2004; 23 Stein, Salomonis, Gusterson (bib25) 2007; 12 Cheng, Weihua, Warner, Gustafsson (bib43) 2004; 101 Visvader, Stingl (bib74) 2014; 28 Strizzi, Bianco, Normanno, Seno, Wechselberger, Wallace-Jones, Khan, Hirota, Sun, Sanicola, Salomon (bib50) 2004; 201 Clarke, Graham, Roman, Sutherland (bib66) 1991; 266 Prezioso, Iaconis, Andolfi, Zentilin, Iavarone, Guardiola, Minchiotti (bib27) 2015; 3 Beleut, Rajaram, Caikovski, Ayyanan, Germano, Choi, Schneider, Brisken (bib58) 2010; 107 Bianco, Strizzi, Normanno, Khan, Salomon (bib2) 2005; 67 Strizzi, Mancino, Bianco, Raafat, Gonzales, Booth, Watanabe, Nagaoka, Mack, Howard, Callahan, Smith, Salomon (bib11) 2008; 216 Raafat, Goldhar, Klauzinska, Xu, Amirjazil, McCurdy, Lashin, Salomon, Vonderhaar, Egan, Callahan (bib18) 2011; 226 Chakrabarti, Wei, Romano, DeCoste, Kang, Sinha (bib48) 2012; 30 Wagner, McAllister, Ward, Davis, Wiseman, Hennighausen (bib17) 2001; 10 Kordon, McKnight, Jhappan, Hennighausen, Merlino, Smith (bib45) 1995; 168 Rajaram, Buric, Caikovski, Ayyanan, Rougemont, Shan, Vainio, Yalcin-Ozuysal, Brisken (bib75) 2015; 34 Oakes, Hilton, Ormandy (bib24) 2006; 8 Anderson, Maraskovsky, Billingsley, Dougall, Tometsko, Roux, Teepe, DuBose, Cosman, Galibert (bib39) 1997; 390 Virgo, Bellward (bib68) 1974; 95 Morkel, Huelsken, Wakamiya, Ding, van de Wetering, Clevers, Taketo, Behringer, Shen, Birchmeier (bib77) 2003; 130 Brisken, Park, Vass, Lydon, O'Malley, Weinberg (bib32) 1998; 95 Raafat, Lawson, Bargo, Klauzinska, Strizzi, Goldhar, Buono, Salomon, Vonderhaar, Callahan (bib20) 2009; 28 Rangel, Karasawa, Castro, Nagaoka, Salomon, Bianco (bib42) 2012; 180 Fendrick, Raafat, Haslam (bib30) 1998; 3 Sternlicht (bib57) 2006; 8 Kenney, Smith, Maroulakou, Green, Muller, Callahan, Salomon, Dickson (bib12) 1996; 15 Liu, Cheng, Flesken-Nikitin, Huang, Nikitin, Pauli (bib47) 2010; 346 Nagaoka, Karasawa, Turbyville, Rangel, Castro, Gonzales, Baker, Seno, Lockett, Greer, Rubin, Salomon, Bianco (bib78) 2013; 25 Bocchinfuso, Lindzey, Hewitt, Clark, Myers, Cooper, Korach (bib61) 2000; 141 Shyamala, Chou, Louie, Guzman, Smith, Nandi (bib29) 2002; 80 23616122 - Sci Transl Med. 2013 Apr 24;5(182):182ra55 23022962 - Cell Signal. 2013 Jan;25(1):178-89 18024957 - J Biol Chem. 2008 Jan 18;283(3):1293-307 11339828 - Exp Cell Res. 2001 May 15;266(1):95-105 21292822 - Mol Endocrinol. 2011 Apr;25(4):635-44 15489919 - Oncogene. 2004 Oct 18;23(48):8017-23 22523003 - Stem Cells. 2012 Jul;30(7):1496-508 20605949 - FASEB J. 2010 Nov;24(11):4408-19 24749068 - Stem Cell Reports. 2014 Apr 8;2(4):427-39 7883078 - Dev Biol. 1995 Mar;168(1):47-61 8491177 - EMBO J. 1993 May;12(5):1835-45 16049342 - Am J Pathol. 2005 Aug;167(2):585-97 16878155 - Oncogene. 2007 Feb 1;26(5):662-72 17431797 - J Mammary Gland Biol Neoplasia. 2007 Mar;12(1):25-35 11241352 - J Cell Physiol. 2001 Apr;187(1):81-9 20624380 - Dev Biol. 2010 Oct 1;346(1):11-24 20616345 - Am J Pathol. 2010 Aug;177(2):532-40 25603931 - EMBO J. 2015 Mar 4;34(5):641-52 12464688 - Physiol Genomics. 2002 Dec 3;11(3):115-32 12737678 - Gynecol Endocrinol. 2003 Apr;17(2):169-76 22272226 - PLoS One. 2012;7(1):e29021 8388996 - Mol Endocrinol. 1993 Apr;7(4):515-27 17291450 - Biochem Biophys Res Commun. 2007 Mar 30;355(1):240-4 21506125 - J Cell Physiol. 2011 Jul;226(7):1940-52 11817542 - Transgenic Res. 2001 Dec;10(6):545-53 7961858 - J Biol Chem. 1994 Nov 18;269(46):28955-62 16954206 - J Biol Chem. 2006 Nov 3;281(44):33497-504 16291788 - Development. 2005 Dec;132(24):5539-51 18174238 - Carcinogenesis. 2008 Mar;29(3):536-43 8561865 - Mol Carcinog. 1996 Jan;15(1):44-56 17338830 - Breast Cancer Res. 2007;9(1):204 18836481 - Oncogene. 2009 Jan 15;28(2):219-30 22952723 - PLoS One. 2012;7(8):e43624 17072321 - Oncogene. 2006 Oct 30;25(51):6680-4 14762170 - Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3739-46 7916676 - Development. 1993 Aug;118(4):1157-68 21982233 - Cell Stem Cell. 2011 Oct 4;9(4):330-44 18276851 - Science. 2008 Aug 1;321(5889):699-702 9790191 - Nature. 1998 Oct 15;395(6703):702-7 9367155 - Nature. 1997 Nov 13;390(6656):175-9 26052513 - Front Cell Dev Biol. 2015 May 21;3:31 17111223 - J Mammary Gland Biol Neoplasia. 2006 Oct;11(3-4):239-48 15949532 - Curr Top Dev Biol. 2005;67:85-133 16572175 - Nature. 2006 Mar 30;440(7084):692-6 7557380 - Genes Dev. 1995 Sep 15;9(18):2266-78 12578528 - Reproduction. 2003 Feb;125(2):143-9 20881963 - Nature. 2010 Nov 4;468(7320):103-7 11897499 - J Steroid Biochem Mol Biol. 2002 Feb;80(2):137-48 20128024 - World J Gastroenterol. 2010 Feb 7;16(5):571-7 4473330 - Endocrinology. 1974 Nov;95(5):1486-90 9013573 - J Biol Chem. 1997 Feb 7;272(6):3330-5 16677418 - Breast Cancer Res. 2006;8(2):207 11880347 - Development. 2002 Mar;129(6):1377-86 17785410 - Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14718-23 8879685 - Breast Cancer Res Treat. 1996;40(2):187-96 11051546 - Cell. 2000 Sep 29;103(1):41-50 10485472 - Cancer Res. 1999 Sep 1;59(17):4276-84 10819501 - J Mammary Gland Biol Neoplasia. 1998 Jan;3(1):7-22 18226190 - Breast Cancer Res. 2008;10(1):101 16524451 - Breast Cancer Res. 2006;8(1):201 18425773 - J Cell Physiol. 2008 Sep;216(3):824-34 17661350 - J Cell Biochem. 2007 Oct 1;102(2):311-9 22542493 - Am J Pathol. 2012 Jun;180(6):2188-200 24014651 - Mol Endocrinol. 2013 Nov;27(11):1808-24 10919287 - Endocrinology. 2000 Aug;141(8):2982-94 1918012 - J Biol Chem. 1991 Oct 5;266(28):18969-75 10959419 - Adv Exp Med Biol. 2000;480:129-38 14623818 - Development. 2003 Dec;130(25):6283-94 18931654 - Nat Biotechnol. 2008 Nov;26(11):1276-84 2373707 - J Biol Chem. 1990 Jul 25;265(21):12694-700 9560231 - Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5076-81 12482969 - Mol Cell Biol. 2003 Jan;23(1):150-62 15897912 - Oncogene. 2005 Jun 9;24(25):4094-105 25153355 - Semin Cancer Biol. 2014 Dec;29:51-8 9336464 - Nucleic Acids Res. 1997 Nov 1;25(21):4323-30 20133621 - Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2989-94 24888586 - Genes Dev. 2014 Jun 1;28(11):1143-58 15334661 - J Cell Physiol. 2004 Nov;201(2):266-76 Raafat (10.1016/j.ajpath.2015.07.023_bib19) 2012; 7 Chakrabarti (10.1016/j.ajpath.2015.07.023_bib48) 2012; 30 Bockamp (10.1016/j.ajpath.2015.07.023_bib26) 2002; 11 Zhang (10.1016/j.ajpath.2015.07.023_bib56) 2010; 16 Raafat (10.1016/j.ajpath.2015.07.023_bib28) 2001; 187 Bianco (10.1016/j.ajpath.2015.07.023_bib5) 2010; 177 Mukherjee (10.1016/j.ajpath.2015.07.023_bib69) 2010; 24 Sun (10.1016/j.ajpath.2015.07.023_bib14) 2005; 167 Shyamala (10.1016/j.ajpath.2015.07.023_bib29) 2002; 80 Miharada (10.1016/j.ajpath.2015.07.023_bib8) 2011; 9 Oakes (10.1016/j.ajpath.2015.07.023_bib24) 2006; 8 Toualbi-Abed (10.1016/j.ajpath.2015.07.023_bib40) 2008; 29 Lydon (10.1016/j.ajpath.2015.07.023_bib73) 1999; 59 Morkel (10.1016/j.ajpath.2015.07.023_bib77) 2003; 130 Nagaoka (10.1016/j.ajpath.2015.07.023_bib78) 2013; 25 Ding (10.1016/j.ajpath.2015.07.023_bib3) 1998; 395 Kordon (10.1016/j.ajpath.2015.07.023_bib45) 1995; 168 Olsson (10.1016/j.ajpath.2015.07.023_bib62) 1996; 40 Wechselberger (10.1016/j.ajpath.2015.07.023_bib13) 2001; 266 Fata (10.1016/j.ajpath.2015.07.023_bib37) 2000; 103 Strizzi (10.1016/j.ajpath.2015.07.023_bib11) 2008; 216 Hewitt (10.1016/j.ajpath.2015.07.023_bib60) 2003; 125 Visvader (10.1016/j.ajpath.2015.07.023_bib74) 2014; 28 Obr (10.1016/j.ajpath.2015.07.023_bib38) 2013; 27 Chu (10.1016/j.ajpath.2015.07.023_bib4) 2005; 132 Feng (10.1016/j.ajpath.2015.07.023_bib23) 2007; 104 Clarke (10.1016/j.ajpath.2015.07.023_bib66) 1991; 266 Jhappan (10.1016/j.ajpath.2015.07.023_bib44) 1993; 12 Rangel (10.1016/j.ajpath.2015.07.023_bib42) 2012; 180 Wagner (10.1016/j.ajpath.2015.07.023_bib16) 2003; 23 Yin (10.1016/j.ajpath.2015.07.023_bib34) 2012; 7 Bocchinfuso (10.1016/j.ajpath.2015.07.023_bib61) 2000; 141 Anderson (10.1016/j.ajpath.2015.07.023_bib70) 2007; 9 Bianco (10.1016/j.ajpath.2015.07.023_bib2) 2005; 67 Clarke (10.1016/j.ajpath.2015.07.023_bib65) 1990; 265 Scribner (10.1016/j.ajpath.2015.07.023_bib53) 2011; 25 Hentschke (10.1016/j.ajpath.2015.07.023_bib63) 2006; 281 Raafat (10.1016/j.ajpath.2015.07.023_bib18) 2011; 226 Prezioso (10.1016/j.ajpath.2015.07.023_bib27) 2015; 3 Aasen (10.1016/j.ajpath.2015.07.023_bib6) 2008; 26 Wechselberger (10.1016/j.ajpath.2015.07.023_bib10) 2005; 24 Strizzi (10.1016/j.ajpath.2015.07.023_bib50) 2004; 201 Rajaram (10.1016/j.ajpath.2015.07.023_bib75) 2015; 34 Stein (10.1016/j.ajpath.2015.07.023_bib25) 2007; 12 Wagner (10.1016/j.ajpath.2015.07.023_bib17) 2001; 10 Raafat (10.1016/j.ajpath.2015.07.023_bib21) 2007; 26 Fendrick (10.1016/j.ajpath.2015.07.023_bib30) 1998; 3 Raafat (10.1016/j.ajpath.2015.07.023_bib20) 2009; 28 Spike (10.1016/j.ajpath.2015.07.023_bib9) 2014; 2 Jones (10.1016/j.ajpath.2015.07.023_bib36) 2006; 440 Quesnelle (10.1016/j.ajpath.2015.07.023_bib55) 2007; 102 Emmen (10.1016/j.ajpath.2015.07.023_bib59) 2003; 17 Tanos (10.1016/j.ajpath.2015.07.023_bib72) 2013; 5 Kannan (10.1016/j.ajpath.2015.07.023_bib49) 1997; 272 Cocolakis (10.1016/j.ajpath.2015.07.023_bib51) 2008; 283 Lieberman (10.1016/j.ajpath.2015.07.023_bib33) 1993; 7 Lydon (10.1016/j.ajpath.2015.07.023_bib31) 1995; 9 Wagner (10.1016/j.ajpath.2015.07.023_bib22) 2002; 129 Cheng (10.1016/j.ajpath.2015.07.023_bib43) 2004; 101 Hamada (10.1016/j.ajpath.2015.07.023_bib76) 2007; 355 Brisken (10.1016/j.ajpath.2015.07.023_bib46) 2006; 11 Dono (10.1016/j.ajpath.2015.07.023_bib64) 1993; 118 Silva (10.1016/j.ajpath.2015.07.023_bib54) 2004; 23 Gilmore (10.1016/j.ajpath.2015.07.023_bib41) 2006; 25 Gonzalez-Suarez (10.1016/j.ajpath.2015.07.023_bib71) 2010; 468 Hofbauer (10.1016/j.ajpath.2015.07.023_bib35) 2008; 10 Beleut (10.1016/j.ajpath.2015.07.023_bib58) 2010; 107 Brisken (10.1016/j.ajpath.2015.07.023_bib32) 1998; 95 Anderson (10.1016/j.ajpath.2015.07.023_bib39) 1997; 390 Chapman (10.1016/j.ajpath.2015.07.023_bib52) 2000; 480 Kenney (10.1016/j.ajpath.2015.07.023_bib12) 1996; 15 Aoi (10.1016/j.ajpath.2015.07.023_bib7) 2008; 321 Liu (10.1016/j.ajpath.2015.07.023_bib47) 2010; 346 Virgo (10.1016/j.ajpath.2015.07.023_bib68) 1974; 95 Wagner (10.1016/j.ajpath.2015.07.023_bib15) 1997; 25 Klauzinska (10.1016/j.ajpath.2015.07.023_bib1) 2014; 29 Savouret (10.1016/j.ajpath.2015.07.023_bib67) 1994; 269 Sternlicht (10.1016/j.ajpath.2015.07.023_bib57) 2006; 8 |
References_xml | – volume: 355 start-page: 240 year: 2007 end-page: 244 ident: bib76 article-title: beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1 publication-title: Biochem Biophys Res Commun contributor: fullname: Salomon – volume: 129 start-page: 1377 year: 2002 end-page: 1386 ident: bib22 article-title: An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal publication-title: Development contributor: fullname: Smith – volume: 25 start-page: 635 year: 2011 end-page: 644 ident: bib53 article-title: Singleminded-2s (Sim2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NFkappaB publication-title: Mol Endocrinol contributor: fullname: Porter – volume: 26 start-page: 662 year: 2007 end-page: 672 ident: bib21 article-title: Kit and PDGFR-alpha activities are necessary for Notch4/Int3-induced tumorigenesis publication-title: Oncogene contributor: fullname: Callahan – volume: 321 start-page: 699 year: 2008 end-page: 702 ident: bib7 article-title: Generation of pluripotent stem cells from adult mouse liver and stomach cells publication-title: Science contributor: fullname: Yamanaka – volume: 480 start-page: 129 year: 2000 end-page: 138 ident: bib52 article-title: The role of Stat3 in apoptosis and mammary gland involution: conditional deletion of Stat3 publication-title: Adv Exp Med Biol contributor: fullname: Watson – volume: 132 start-page: 5539 year: 2005 end-page: 5551 ident: bib4 article-title: Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis publication-title: Development contributor: fullname: Shen – volume: 107 start-page: 2989 year: 2010 end-page: 2994 ident: bib58 article-title: Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland publication-title: Proc Natl Acad Sci U S A contributor: fullname: Brisken – volume: 3 start-page: 7 year: 1998 end-page: 22 ident: bib30 article-title: Mammary gland growth and development from the postnatal period to postmenopause: ovarian steroid receptor ontogeny and regulation in the mouse publication-title: J Mammary Gland Biol Neoplasia contributor: fullname: Haslam – volume: 95 start-page: 5076 year: 1998 end-page: 5081 ident: bib32 article-title: A paracrine role for the epithelial progesterone receptor in mammary gland development publication-title: Proc Natl Acad Sci U S A contributor: fullname: Weinberg – volume: 24 start-page: 4408 year: 2010 end-page: 4419 ident: bib69 article-title: Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression publication-title: FASEB J contributor: fullname: Lydon – volume: 23 start-page: 150 year: 2003 end-page: 162 ident: bib16 article-title: Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues publication-title: Mol Cell Biol contributor: fullname: Hennighausen – volume: 187 start-page: 81 year: 2001 end-page: 89 ident: bib28 article-title: Estrogen and estrogen plus progestin act directly on the mammary gland to increase proliferation in a postmenopausal mouse model publication-title: J Cell Physiol contributor: fullname: Haslam – volume: 26 start-page: 1276 year: 2008 end-page: 1284 ident: bib6 article-title: Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes publication-title: Nat Biotechnol contributor: fullname: Izpisua Belmonte – volume: 440 start-page: 692 year: 2006 end-page: 696 ident: bib36 article-title: Regulation of cancer cell migration and bone metastasis by RANKL publication-title: Nature contributor: fullname: Penninger – volume: 95 start-page: 1486 year: 1974 end-page: 1490 ident: bib68 article-title: Serum progesterone levels in the pregnant and postpartum laboratory mouse publication-title: Endocrinology contributor: fullname: Bellward – volume: 9 start-page: 330 year: 2011 end-page: 344 ident: bib8 article-title: Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78 publication-title: Cell Stem Cell contributor: fullname: Karlsson – volume: 59 start-page: 4276 year: 1999 end-page: 4284 ident: bib73 article-title: Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function publication-title: Cancer Res contributor: fullname: O'Malley – volume: 25 start-page: 178 year: 2013 end-page: 189 ident: bib78 article-title: Cripto-1 enhances the canonical Wnt/beta-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors publication-title: Cell Signal contributor: fullname: Bianco – volume: 102 start-page: 311 year: 2007 end-page: 319 ident: bib55 article-title: STAT-mediated EGFR signaling in cancer publication-title: J Cell Biochem contributor: fullname: Grandis – volume: 118 start-page: 1157 year: 1993 end-page: 1168 ident: bib64 article-title: The murine cripto gene: expression during mesoderm induction and early heart morphogenesis publication-title: Development contributor: fullname: Simeone – volume: 216 start-page: 824 year: 2008 end-page: 834 ident: bib11 article-title: Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland publication-title: J Cell Physiol contributor: fullname: Salomon – volume: 30 start-page: 1496 year: 2012 end-page: 1508 ident: bib48 article-title: Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling publication-title: Stem Cells contributor: fullname: Sinha – volume: 468 start-page: 103 year: 2010 end-page: 107 ident: bib71 article-title: RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis publication-title: Nature contributor: fullname: Dougall – volume: 24 start-page: 4094 year: 2005 end-page: 4105 ident: bib10 article-title: Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma publication-title: Oncogene contributor: fullname: Salomon – volume: 167 start-page: 585 year: 2005 end-page: 597 ident: bib14 article-title: Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis publication-title: Am J Pathol contributor: fullname: Salomon – volume: 390 start-page: 175 year: 1997 end-page: 179 ident: bib39 article-title: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function publication-title: Nature contributor: fullname: Galibert – volume: 25 start-page: 4323 year: 1997 end-page: 4330 ident: bib15 article-title: Cre-mediated gene deletion in the mammary gland publication-title: Nucleic Acids Res contributor: fullname: Hennighausen – volume: 9 start-page: 2266 year: 1995 end-page: 2278 ident: bib31 article-title: Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities publication-title: Genes Dev contributor: fullname: O'Malley – volume: 177 start-page: 532 year: 2010 end-page: 540 ident: bib5 article-title: Role of Cripto-1 in stem cell maintenance and malignant progression publication-title: Am J Pathol contributor: fullname: Salomon – volume: 7 start-page: e29021 year: 2012 ident: bib34 article-title: Genome-wide progesterone receptor binding: cell type- specific and shared mechanisms in T47D breast cancer cells and primary leiomyoma cells publication-title: PLoS One contributor: fullname: Bulun – volume: 9 start-page: 204 year: 2007 ident: bib70 article-title: Key stages in mammary gland development–secretory activation in the mammary gland: it's not just about milk protein synthesis! publication-title: Breast Cancer Res contributor: fullname: Neville – volume: 29 start-page: 536 year: 2008 end-page: 543 ident: bib40 article-title: Jun D cooperates with p65 to activate the proximal kappaB site of the cyclin D1 promoter: role of PI3K/PDK-1 publication-title: Carcinogenesis contributor: fullname: Bernuau – volume: 25 start-page: 6680 year: 2006 end-page: 6684 ident: bib41 article-title: Introduction to NF-kappaB: players, pathways, perspectives publication-title: Oncogene contributor: fullname: Gilmore – volume: 7 start-page: 515 year: 1993 end-page: 527 ident: bib33 article-title: The constitution of a progesterone response element publication-title: Mol Endocrinol contributor: fullname: Nordeen – volume: 7 start-page: e43624 year: 2012 ident: bib19 article-title: Effects of age and parity on mammary gland lesions and progenitor cells in the FVB/N-RC mice publication-title: PLoS One contributor: fullname: Callahan – volume: 27 start-page: 1808 year: 2013 end-page: 1824 ident: bib38 article-title: Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells publication-title: Mol Endocrinol contributor: fullname: Edwards – volume: 283 start-page: 1293 year: 2008 end-page: 1307 ident: bib51 article-title: Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation publication-title: J Biol Chem contributor: fullname: Lebrun – volume: 16 start-page: 571 year: 2010 end-page: 577 ident: bib56 article-title: Significance and relationship between Cripto-1 and p- STAT3 expression in gastric cancer and precancerous lesions publication-title: World J Gastroenterol contributor: fullname: Xin – volume: 80 start-page: 137 year: 2002 end-page: 148 ident: bib29 article-title: Cellular expression of estrogen and progesterone receptors in mammary glands: regulation by hormones, development and aging publication-title: J Steroid Biochem Mol Biol contributor: fullname: Nandi – volume: 125 start-page: 143 year: 2003 end-page: 149 ident: bib60 article-title: Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues publication-title: Reproduction contributor: fullname: Korach – volume: 67 start-page: 85 year: 2005 end-page: 133 ident: bib2 article-title: Cripto-1: an oncofetal gene with many faces publication-title: Curr Top Dev Biol contributor: fullname: Salomon – volume: 10 start-page: 545 year: 2001 end-page: 553 ident: bib17 article-title: Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice publication-title: Transgenic Res contributor: fullname: Hennighausen – volume: 226 start-page: 1940 year: 2011 end-page: 1952 ident: bib18 article-title: Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland publication-title: J Cell Physiol contributor: fullname: Callahan – volume: 3 start-page: 31 year: 2015 ident: bib27 article-title: Conditional Cripto overexpression in satellite cells promotes myogenic commitment and enhances early regeneration publication-title: Front Cell Dev Biol contributor: fullname: Minchiotti – volume: 201 start-page: 266 year: 2004 end-page: 276 ident: bib50 article-title: Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice publication-title: J Cell Physiol contributor: fullname: Salomon – volume: 180 start-page: 2188 year: 2012 end-page: 2200 ident: bib42 article-title: Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer publication-title: Am J Pathol contributor: fullname: Bianco – volume: 17 start-page: 169 year: 2003 end-page: 176 ident: bib59 article-title: Estrogen receptor knockout mice: phenotypes in the female reproductive tract publication-title: Gynecol Endocrinol contributor: fullname: Korach – volume: 8 start-page: 207 year: 2006 ident: bib24 article-title: The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium publication-title: Breast Cancer Res contributor: fullname: Ormandy – volume: 130 start-page: 6283 year: 2003 end-page: 6294 ident: bib77 article-title: Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation publication-title: Development contributor: fullname: Birchmeier – volume: 2 start-page: 427 year: 2014 end-page: 439 ident: bib9 article-title: CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo publication-title: Stem Cell Reports contributor: fullname: Gray – volume: 265 start-page: 12694 year: 1990 end-page: 12700 ident: bib65 article-title: Progesterone receptor regulation by retinoic acid in the human breast cancer cell line T-47D publication-title: J Biol Chem contributor: fullname: Sutherland – volume: 168 start-page: 47 year: 1995 end-page: 61 ident: bib45 article-title: Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population publication-title: Dev Biol contributor: fullname: Smith – volume: 104 start-page: 14718 year: 2007 end-page: 14723 ident: bib23 article-title: Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice publication-title: Proc Natl Acad Sci U S A contributor: fullname: Khan – volume: 23 start-page: 8017 year: 2004 end-page: 8023 ident: bib54 article-title: Role of STATs as downstream signal transducers in Src family kinase- mediated tumorigenesis publication-title: Oncogene contributor: fullname: Silva – volume: 29 start-page: 51 year: 2014 end-page: 58 ident: bib1 article-title: The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition publication-title: Semin Cancer Biol contributor: fullname: Salomon – volume: 12 start-page: 25 year: 2007 end-page: 35 ident: bib25 article-title: Mammary gland involution as a multi-step process publication-title: J Mammary Gland Biol Neoplasia contributor: fullname: Gusterson – volume: 346 start-page: 11 year: 2010 end-page: 24 ident: bib47 article-title: Conditional knockout of fibronectin abrogates mouse mammary gland lobuloalveolar differentiation publication-title: Dev Biol contributor: fullname: Pauli – volume: 40 start-page: 187 year: 1996 end-page: 196 ident: bib62 article-title: Proliferation of the breast epithelium in relation to menstrual cycle phase, hormonal use, and reproductive factors publication-title: Breast Cancer Res Treat contributor: fullname: Ryden – volume: 266 start-page: 18969 year: 1991 end-page: 18975 ident: bib66 article-title: Direct transcriptional regulation of the progesterone receptor by retinoic acid diminishes progestin responsiveness in the breast cancer cell line T-47D publication-title: J Biol Chem contributor: fullname: Sutherland – volume: 5 start-page: 182ra155 year: 2013 ident: bib72 article-title: Progesterone/RANKL is a major regulatory axis in the human breast publication-title: Sci Transl Med contributor: fullname: Brisken – volume: 11 start-page: 115 year: 2002 end-page: 132 ident: bib26 article-title: Of mice and models: improved animal models for biomedical research publication-title: Physiol Genomics contributor: fullname: Zabel – volume: 28 start-page: 219 year: 2009 end-page: 230 ident: bib20 article-title: Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis publication-title: Oncogene contributor: fullname: Callahan – volume: 281 start-page: 33497 year: 2006 end-page: 33504 ident: bib63 article-title: Germ cell nuclear factor is a repressor of CRIPTO-1 and CRIPTO-3 publication-title: J Biol Chem contributor: fullname: Hubner – volume: 15 start-page: 44 year: 1996 end-page: 56 ident: bib12 article-title: Detection of amphiregulin and Cripto-1 in mammary tumors from transgenic mice publication-title: Mol Carcinog contributor: fullname: Dickson – volume: 34 start-page: 641 year: 2015 end-page: 652 ident: bib75 article-title: Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk publication-title: EMBO J contributor: fullname: Brisken – volume: 11 start-page: 239 year: 2006 end-page: 248 ident: bib46 article-title: Alveolar and lactogenic differentiation publication-title: J Mammary Gland Biol Neoplasia contributor: fullname: Rajaram – volume: 8 start-page: 201 year: 2006 ident: bib57 article-title: Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis publication-title: Breast Cancer Res contributor: fullname: Sternlicht – volume: 10 start-page: 101 year: 2008 ident: bib35 article-title: Fatal attraction: why breast cancer cells home to bone publication-title: Breast Cancer Res contributor: fullname: Singh – volume: 12 start-page: 1835 year: 1993 end-page: 1845 ident: bib44 article-title: Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation publication-title: EMBO J contributor: fullname: Merlino – volume: 141 start-page: 2982 year: 2000 end-page: 2994 ident: bib61 article-title: Induction of mammary gland development in estrogen receptor-alpha knockout mice publication-title: Endocrinology contributor: fullname: Korach – volume: 101 start-page: 3739 year: 2004 end-page: 3746 ident: bib43 article-title: Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland publication-title: Proc Natl Acad Sci U S A contributor: fullname: Gustafsson – volume: 272 start-page: 3330 year: 1997 end-page: 3335 ident: bib49 article-title: Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells publication-title: J Biol Chem contributor: fullname: Salomon – volume: 28 start-page: 1143 year: 2014 end-page: 1158 ident: bib74 article-title: Mammary stem cells and the differentiation hierarchy: current status and perspectives publication-title: Genes Dev contributor: fullname: Stingl – volume: 395 start-page: 702 year: 1998 end-page: 707 ident: bib3 article-title: Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo publication-title: Nature contributor: fullname: Shen – volume: 266 start-page: 95 year: 2001 end-page: 105 ident: bib13 article-title: Cripto-1 enhances migration and branching morphogenesis of mouse mammary epithelial cells publication-title: Exp Cell Res contributor: fullname: Salomon – volume: 103 start-page: 41 year: 2000 end-page: 50 ident: bib37 article-title: The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development publication-title: Cell contributor: fullname: Penninger – volume: 269 start-page: 28955 year: 1994 end-page: 28962 ident: bib67 article-title: Interplay between estrogens, progestins, retinoic acid and AP-1 on a single regulatory site in the progesterone receptor gene publication-title: J Biol Chem contributor: fullname: Milgrom – volume: 23 start-page: 8017 year: 2004 ident: 10.1016/j.ajpath.2015.07.023_bib54 article-title: Role of STATs as downstream signal transducers in Src family kinase- mediated tumorigenesis publication-title: Oncogene doi: 10.1038/sj.onc.1208159 contributor: fullname: Silva – volume: 177 start-page: 532 year: 2010 ident: 10.1016/j.ajpath.2015.07.023_bib5 article-title: Role of Cripto-1 in stem cell maintenance and malignant progression publication-title: Am J Pathol doi: 10.2353/ajpath.2010.100102 contributor: fullname: Bianco – volume: 95 start-page: 1486 year: 1974 ident: 10.1016/j.ajpath.2015.07.023_bib68 article-title: Serum progesterone levels in the pregnant and postpartum laboratory mouse publication-title: Endocrinology doi: 10.1210/endo-95-5-1486 contributor: fullname: Virgo – volume: 130 start-page: 6283 year: 2003 ident: 10.1016/j.ajpath.2015.07.023_bib77 article-title: Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation publication-title: Development doi: 10.1242/dev.00859 contributor: fullname: Morkel – volume: 27 start-page: 1808 year: 2013 ident: 10.1016/j.ajpath.2015.07.023_bib38 article-title: Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells publication-title: Mol Endocrinol doi: 10.1210/me.2013-1077 contributor: fullname: Obr – volume: 265 start-page: 12694 year: 1990 ident: 10.1016/j.ajpath.2015.07.023_bib65 article-title: Progesterone receptor regulation by retinoic acid in the human breast cancer cell line T-47D publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)38400-5 contributor: fullname: Clarke – volume: 8 start-page: 207 year: 2006 ident: 10.1016/j.ajpath.2015.07.023_bib24 article-title: The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium publication-title: Breast Cancer Res doi: 10.1186/bcr1411 contributor: fullname: Oakes – volume: 30 start-page: 1496 year: 2012 ident: 10.1016/j.ajpath.2015.07.023_bib48 article-title: Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling publication-title: Stem Cells doi: 10.1002/stem.1112 contributor: fullname: Chakrabarti – volume: 101 start-page: 3739 year: 2004 ident: 10.1016/j.ajpath.2015.07.023_bib43 article-title: Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0307864100 contributor: fullname: Cheng – volume: 266 start-page: 95 year: 2001 ident: 10.1016/j.ajpath.2015.07.023_bib13 article-title: Cripto-1 enhances migration and branching morphogenesis of mouse mammary epithelial cells publication-title: Exp Cell Res doi: 10.1006/excr.2001.5195 contributor: fullname: Wechselberger – volume: 7 start-page: 515 year: 1993 ident: 10.1016/j.ajpath.2015.07.023_bib33 article-title: The constitution of a progesterone response element publication-title: Mol Endocrinol contributor: fullname: Lieberman – volume: 283 start-page: 1293 year: 2008 ident: 10.1016/j.ajpath.2015.07.023_bib51 article-title: Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation publication-title: J Biol Chem doi: 10.1074/jbc.M707492200 contributor: fullname: Cocolakis – volume: 269 start-page: 28955 year: 1994 ident: 10.1016/j.ajpath.2015.07.023_bib67 article-title: Interplay between estrogens, progestins, retinoic acid and AP-1 on a single regulatory site in the progesterone receptor gene publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)61999-X contributor: fullname: Savouret – volume: 2 start-page: 427 year: 2014 ident: 10.1016/j.ajpath.2015.07.023_bib9 article-title: CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo publication-title: Stem Cell Reports doi: 10.1016/j.stemcr.2014.02.010 contributor: fullname: Spike – volume: 10 start-page: 545 year: 2001 ident: 10.1016/j.ajpath.2015.07.023_bib17 article-title: Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice publication-title: Transgenic Res doi: 10.1023/A:1013063514007 contributor: fullname: Wagner – volume: 26 start-page: 662 year: 2007 ident: 10.1016/j.ajpath.2015.07.023_bib21 article-title: Kit and PDGFR-alpha activities are necessary for Notch4/Int3-induced tumorigenesis publication-title: Oncogene doi: 10.1038/sj.onc.1209823 contributor: fullname: Raafat – volume: 80 start-page: 137 year: 2002 ident: 10.1016/j.ajpath.2015.07.023_bib29 article-title: Cellular expression of estrogen and progesterone receptors in mammary glands: regulation by hormones, development and aging publication-title: J Steroid Biochem Mol Biol doi: 10.1016/S0960-0760(01)00182-0 contributor: fullname: Shyamala – volume: 3 start-page: 7 year: 1998 ident: 10.1016/j.ajpath.2015.07.023_bib30 article-title: Mammary gland growth and development from the postnatal period to postmenopause: ovarian steroid receptor ontogeny and regulation in the mouse publication-title: J Mammary Gland Biol Neoplasia doi: 10.1023/A:1018766000275 contributor: fullname: Fendrick – volume: 26 start-page: 1276 year: 2008 ident: 10.1016/j.ajpath.2015.07.023_bib6 article-title: Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes publication-title: Nat Biotechnol doi: 10.1038/nbt.1503 contributor: fullname: Aasen – volume: 25 start-page: 4323 year: 1997 ident: 10.1016/j.ajpath.2015.07.023_bib15 article-title: Cre-mediated gene deletion in the mammary gland publication-title: Nucleic Acids Res doi: 10.1093/nar/25.21.4323 contributor: fullname: Wagner – volume: 104 start-page: 14718 year: 2007 ident: 10.1016/j.ajpath.2015.07.023_bib23 article-title: Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0706933104 contributor: fullname: Feng – volume: 9 start-page: 330 year: 2011 ident: 10.1016/j.ajpath.2015.07.023_bib8 article-title: Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.07.016 contributor: fullname: Miharada – volume: 226 start-page: 1940 year: 2011 ident: 10.1016/j.ajpath.2015.07.023_bib18 article-title: Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland publication-title: J Cell Physiol doi: 10.1002/jcp.22526 contributor: fullname: Raafat – volume: 102 start-page: 311 year: 2007 ident: 10.1016/j.ajpath.2015.07.023_bib55 article-title: STAT-mediated EGFR signaling in cancer publication-title: J Cell Biochem doi: 10.1002/jcb.21475 contributor: fullname: Quesnelle – volume: 16 start-page: 571 year: 2010 ident: 10.1016/j.ajpath.2015.07.023_bib56 article-title: Significance and relationship between Cripto-1 and p- STAT3 expression in gastric cancer and precancerous lesions publication-title: World J Gastroenterol doi: 10.3748/wjg.v16.i5.571 contributor: fullname: Zhang – volume: 266 start-page: 18969 year: 1991 ident: 10.1016/j.ajpath.2015.07.023_bib66 article-title: Direct transcriptional regulation of the progesterone receptor by retinoic acid diminishes progestin responsiveness in the breast cancer cell line T-47D publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)55158-9 contributor: fullname: Clarke – volume: 15 start-page: 44 year: 1996 ident: 10.1016/j.ajpath.2015.07.023_bib12 article-title: Detection of amphiregulin and Cripto-1 in mammary tumors from transgenic mice publication-title: Mol Carcinog doi: 10.1002/(SICI)1098-2744(199601)15:1<44::AID-MC7>3.0.CO;2-S contributor: fullname: Kenney – volume: 28 start-page: 1143 year: 2014 ident: 10.1016/j.ajpath.2015.07.023_bib74 article-title: Mammary stem cells and the differentiation hierarchy: current status and perspectives publication-title: Genes Dev doi: 10.1101/gad.242511.114 contributor: fullname: Visvader – volume: 216 start-page: 824 year: 2008 ident: 10.1016/j.ajpath.2015.07.023_bib11 article-title: Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland publication-title: J Cell Physiol doi: 10.1002/jcp.21462 contributor: fullname: Strizzi – volume: 25 start-page: 635 year: 2011 ident: 10.1016/j.ajpath.2015.07.023_bib53 article-title: Singleminded-2s (Sim2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NFkappaB publication-title: Mol Endocrinol doi: 10.1210/me.2010-0423 contributor: fullname: Scribner – volume: 3 start-page: 31 year: 2015 ident: 10.1016/j.ajpath.2015.07.023_bib27 article-title: Conditional Cripto overexpression in satellite cells promotes myogenic commitment and enhances early regeneration publication-title: Front Cell Dev Biol doi: 10.3389/fcell.2015.00031 contributor: fullname: Prezioso – volume: 5 start-page: 182ra155 year: 2013 ident: 10.1016/j.ajpath.2015.07.023_bib72 article-title: Progesterone/RANKL is a major regulatory axis in the human breast publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3005654 contributor: fullname: Tanos – volume: 34 start-page: 641 year: 2015 ident: 10.1016/j.ajpath.2015.07.023_bib75 article-title: Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk publication-title: EMBO J doi: 10.15252/embj.201490434 contributor: fullname: Rajaram – volume: 59 start-page: 4276 year: 1999 ident: 10.1016/j.ajpath.2015.07.023_bib73 article-title: Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function publication-title: Cancer Res contributor: fullname: Lydon – volume: 180 start-page: 2188 year: 2012 ident: 10.1016/j.ajpath.2015.07.023_bib42 article-title: Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer publication-title: Am J Pathol doi: 10.1016/j.ajpath.2012.02.031 contributor: fullname: Rangel – volume: 28 start-page: 219 year: 2009 ident: 10.1016/j.ajpath.2015.07.023_bib20 article-title: Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis publication-title: Oncogene doi: 10.1038/onc.2008.379 contributor: fullname: Raafat – volume: 25 start-page: 178 year: 2013 ident: 10.1016/j.ajpath.2015.07.023_bib78 article-title: Cripto-1 enhances the canonical Wnt/beta-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors publication-title: Cell Signal doi: 10.1016/j.cellsig.2012.09.024 contributor: fullname: Nagaoka – volume: 440 start-page: 692 year: 2006 ident: 10.1016/j.ajpath.2015.07.023_bib36 article-title: Regulation of cancer cell migration and bone metastasis by RANKL publication-title: Nature doi: 10.1038/nature04524 contributor: fullname: Jones – volume: 29 start-page: 51 year: 2014 ident: 10.1016/j.ajpath.2015.07.023_bib1 article-title: The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2014.08.003 contributor: fullname: Klauzinska – volume: 167 start-page: 585 year: 2005 ident: 10.1016/j.ajpath.2015.07.023_bib14 article-title: Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)63000-3 contributor: fullname: Sun – volume: 17 start-page: 169 year: 2003 ident: 10.1016/j.ajpath.2015.07.023_bib59 article-title: Estrogen receptor knockout mice: phenotypes in the female reproductive tract publication-title: Gynecol Endocrinol doi: 10.1080/gye.17.2.169.176 contributor: fullname: Emmen – volume: 12 start-page: 25 year: 2007 ident: 10.1016/j.ajpath.2015.07.023_bib25 article-title: Mammary gland involution as a multi-step process publication-title: J Mammary Gland Biol Neoplasia doi: 10.1007/s10911-007-9035-7 contributor: fullname: Stein – volume: 187 start-page: 81 year: 2001 ident: 10.1016/j.ajpath.2015.07.023_bib28 article-title: Estrogen and estrogen plus progestin act directly on the mammary gland to increase proliferation in a postmenopausal mouse model publication-title: J Cell Physiol doi: 10.1002/1097-4652(2001)9999:9999<::AID-JCP1056>3.0.CO;2-0 contributor: fullname: Raafat – volume: 468 start-page: 103 year: 2010 ident: 10.1016/j.ajpath.2015.07.023_bib71 article-title: RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis publication-title: Nature doi: 10.1038/nature09495 contributor: fullname: Gonzalez-Suarez – volume: 95 start-page: 5076 year: 1998 ident: 10.1016/j.ajpath.2015.07.023_bib32 article-title: A paracrine role for the epithelial progesterone receptor in mammary gland development publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.95.9.5076 contributor: fullname: Brisken – volume: 9 start-page: 2266 year: 1995 ident: 10.1016/j.ajpath.2015.07.023_bib31 article-title: Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities publication-title: Genes Dev doi: 10.1101/gad.9.18.2266 contributor: fullname: Lydon – volume: 321 start-page: 699 year: 2008 ident: 10.1016/j.ajpath.2015.07.023_bib7 article-title: Generation of pluripotent stem cells from adult mouse liver and stomach cells publication-title: Science doi: 10.1126/science.1154884 contributor: fullname: Aoi – volume: 25 start-page: 6680 year: 2006 ident: 10.1016/j.ajpath.2015.07.023_bib41 article-title: Introduction to NF-kappaB: players, pathways, perspectives publication-title: Oncogene doi: 10.1038/sj.onc.1209954 contributor: fullname: Gilmore – volume: 7 start-page: e43624 year: 2012 ident: 10.1016/j.ajpath.2015.07.023_bib19 article-title: Effects of age and parity on mammary gland lesions and progenitor cells in the FVB/N-RC mice publication-title: PLoS One doi: 10.1371/journal.pone.0043624 contributor: fullname: Raafat – volume: 390 start-page: 175 year: 1997 ident: 10.1016/j.ajpath.2015.07.023_bib39 article-title: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function publication-title: Nature doi: 10.1038/36593 contributor: fullname: Anderson – volume: 125 start-page: 143 year: 2003 ident: 10.1016/j.ajpath.2015.07.023_bib60 article-title: Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues publication-title: Reproduction doi: 10.1530/rep.0.1250143 contributor: fullname: Hewitt – volume: 9 start-page: 204 year: 2007 ident: 10.1016/j.ajpath.2015.07.023_bib70 article-title: Key stages in mammary gland development–secretory activation in the mammary gland: it's not just about milk protein synthesis! publication-title: Breast Cancer Res doi: 10.1186/bcr1653 contributor: fullname: Anderson – volume: 129 start-page: 1377 year: 2002 ident: 10.1016/j.ajpath.2015.07.023_bib22 article-title: An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal publication-title: Development doi: 10.1242/dev.129.6.1377 contributor: fullname: Wagner – volume: 8 start-page: 201 year: 2006 ident: 10.1016/j.ajpath.2015.07.023_bib57 article-title: Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis publication-title: Breast Cancer Res doi: 10.1186/bcr1368 contributor: fullname: Sternlicht – volume: 24 start-page: 4094 year: 2005 ident: 10.1016/j.ajpath.2015.07.023_bib10 article-title: Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma publication-title: Oncogene doi: 10.1038/sj.onc.1208417 contributor: fullname: Wechselberger – volume: 118 start-page: 1157 year: 1993 ident: 10.1016/j.ajpath.2015.07.023_bib64 article-title: The murine cripto gene: expression during mesoderm induction and early heart morphogenesis publication-title: Development doi: 10.1242/dev.118.4.1157 contributor: fullname: Dono – volume: 103 start-page: 41 year: 2000 ident: 10.1016/j.ajpath.2015.07.023_bib37 article-title: The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development publication-title: Cell doi: 10.1016/S0092-8674(00)00103-3 contributor: fullname: Fata – volume: 10 start-page: 101 year: 2008 ident: 10.1016/j.ajpath.2015.07.023_bib35 article-title: Fatal attraction: why breast cancer cells home to bone publication-title: Breast Cancer Res doi: 10.1186/bcr1848 contributor: fullname: Hofbauer – volume: 11 start-page: 239 year: 2006 ident: 10.1016/j.ajpath.2015.07.023_bib46 article-title: Alveolar and lactogenic differentiation publication-title: J Mammary Gland Biol Neoplasia doi: 10.1007/s10911-006-9026-0 contributor: fullname: Brisken – volume: 107 start-page: 2989 year: 2010 ident: 10.1016/j.ajpath.2015.07.023_bib58 article-title: Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0915148107 contributor: fullname: Beleut – volume: 132 start-page: 5539 year: 2005 ident: 10.1016/j.ajpath.2015.07.023_bib4 article-title: Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis publication-title: Development doi: 10.1242/dev.02157 contributor: fullname: Chu – volume: 7 start-page: e29021 year: 2012 ident: 10.1016/j.ajpath.2015.07.023_bib34 article-title: Genome-wide progesterone receptor binding: cell type- specific and shared mechanisms in T47D breast cancer cells and primary leiomyoma cells publication-title: PLoS One doi: 10.1371/journal.pone.0029021 contributor: fullname: Yin – volume: 67 start-page: 85 year: 2005 ident: 10.1016/j.ajpath.2015.07.023_bib2 article-title: Cripto-1: an oncofetal gene with many faces publication-title: Curr Top Dev Biol doi: 10.1016/S0070-2153(05)67003-2 contributor: fullname: Bianco – volume: 395 start-page: 702 year: 1998 ident: 10.1016/j.ajpath.2015.07.023_bib3 article-title: Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo publication-title: Nature doi: 10.1038/27215 contributor: fullname: Ding – volume: 272 start-page: 3330 year: 1997 ident: 10.1016/j.ajpath.2015.07.023_bib49 article-title: Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells publication-title: J Biol Chem doi: 10.1074/jbc.272.6.3330 contributor: fullname: Kannan – volume: 12 start-page: 1835 year: 1993 ident: 10.1016/j.ajpath.2015.07.023_bib44 article-title: Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation publication-title: EMBO J doi: 10.1002/j.1460-2075.1993.tb05832.x contributor: fullname: Jhappan – volume: 201 start-page: 266 year: 2004 ident: 10.1016/j.ajpath.2015.07.023_bib50 article-title: Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice publication-title: J Cell Physiol doi: 10.1002/jcp.20062 contributor: fullname: Strizzi – volume: 480 start-page: 129 year: 2000 ident: 10.1016/j.ajpath.2015.07.023_bib52 article-title: The role of Stat3 in apoptosis and mammary gland involution: conditional deletion of Stat3 publication-title: Adv Exp Med Biol doi: 10.1007/0-306-46832-8_16 contributor: fullname: Chapman – volume: 29 start-page: 536 year: 2008 ident: 10.1016/j.ajpath.2015.07.023_bib40 article-title: Jun D cooperates with p65 to activate the proximal kappaB site of the cyclin D1 promoter: role of PI3K/PDK-1 publication-title: Carcinogenesis doi: 10.1093/carcin/bgm293 contributor: fullname: Toualbi-Abed – volume: 346 start-page: 11 year: 2010 ident: 10.1016/j.ajpath.2015.07.023_bib47 article-title: Conditional knockout of fibronectin abrogates mouse mammary gland lobuloalveolar differentiation publication-title: Dev Biol doi: 10.1016/j.ydbio.2010.07.001 contributor: fullname: Liu – volume: 40 start-page: 187 year: 1996 ident: 10.1016/j.ajpath.2015.07.023_bib62 article-title: Proliferation of the breast epithelium in relation to menstrual cycle phase, hormonal use, and reproductive factors publication-title: Breast Cancer Res Treat doi: 10.1007/BF01806214 contributor: fullname: Olsson – volume: 141 start-page: 2982 year: 2000 ident: 10.1016/j.ajpath.2015.07.023_bib61 article-title: Induction of mammary gland development in estrogen receptor-alpha knockout mice publication-title: Endocrinology doi: 10.1210/endo.141.8.7609 contributor: fullname: Bocchinfuso – volume: 281 start-page: 33497 year: 2006 ident: 10.1016/j.ajpath.2015.07.023_bib63 article-title: Germ cell nuclear factor is a repressor of CRIPTO-1 and CRIPTO-3 publication-title: J Biol Chem doi: 10.1074/jbc.M606975200 contributor: fullname: Hentschke – volume: 168 start-page: 47 year: 1995 ident: 10.1016/j.ajpath.2015.07.023_bib45 article-title: Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population publication-title: Dev Biol doi: 10.1006/dbio.1995.1060 contributor: fullname: Kordon – volume: 355 start-page: 240 year: 2007 ident: 10.1016/j.ajpath.2015.07.023_bib76 article-title: beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2007.01.143 contributor: fullname: Hamada – volume: 23 start-page: 150 year: 2003 ident: 10.1016/j.ajpath.2015.07.023_bib16 article-title: Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues publication-title: Mol Cell Biol doi: 10.1128/MCB.23.1.150-162.2003 contributor: fullname: Wagner – volume: 24 start-page: 4408 year: 2010 ident: 10.1016/j.ajpath.2015.07.023_bib69 article-title: Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression publication-title: FASEB J doi: 10.1096/fj.10-157982 contributor: fullname: Mukherjee – volume: 11 start-page: 115 year: 2002 ident: 10.1016/j.ajpath.2015.07.023_bib26 article-title: Of mice and models: improved animal models for biomedical research publication-title: Physiol Genomics doi: 10.1152/physiolgenomics.00067.2002 contributor: fullname: Bockamp |
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Snippet | Cripto-1, a member of the epidermal growth factor–Cripto-1/FRL-1/Cryptic family, is critical for early embryonic development. Together with its ligand Nodal,... Cripto-1, a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic family, is critical for early embryonic development. Together with its ligand Nodal,... |
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SubjectTerms | Animals Cell Proliferation Epidermal Growth Factor - genetics Epidermal Growth Factor - metabolism Epithelial Cells Epithelial-Mesenchymal Transition Female Humans Mammary Glands, Animal - cytology Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Mice, Knockout Models, Biological Neoplasm Proteins - genetics Neoplasm Proteins - metabolism NF-kappa B p50 Subunit - genetics NF-kappa B p50 Subunit - metabolism Organ Specificity Pathology Pregnancy RANK Ligand - genetics RANK Ligand - metabolism Receptor Activator of Nuclear Factor-kappa B - genetics Receptor Activator of Nuclear Factor-kappa B - metabolism Receptors, Progesterone - genetics Receptors, Progesterone - metabolism Regular Signal Transduction |
Title | Cripto-1 Ablation Disrupts Alveolar Development in the Mouse Mammary Gland through a Progesterone Receptor–Mediated Pathway |
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