Asymmetric formal C–C bond insertion into aldehydes via copper-catalyzed diyne cyclization

• Published in: Nature communications Vol. 14; no. 1; pp. 7058 - 10
• Main Authors: Li, Cui-Ting, Qi, Lin-Jun, Liu, Li-Gao, Ge, Chang, Lu, Xin, Ye, Long-Wu, Zhou, Bo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.11.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 119/118; 140/131; 140/58; 639/638/403/933; 639/638/403/934; Aldehydes; Assembly; Asymmetry; Carbon; Carbonyl compounds; Carbonyls; Catalysis; Catalysts; Chemistry; Copper; Covalent bonds; Enantiomers; Homology; Humanities and Social Sciences; Insertion; Laboratories; Ligands; multidisciplinary; Phosphine; Phosphines; Reaction mechanisms; Regioselectivity; Science; Science (multidisciplinary); Stereoselectivity

The formal C–C bond insertion into aldehydes is an attractive methodology for the assembly of homologated carbonyl compounds. However, the homologation of aldehydes has been limited to diazo approach and the enantioselective reaction was rarely developed. Herein, we report an asymmetric formal C–C b...