High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma

• Published in: Gynecologic oncology Vol. 128; no. 2; pp. 327 - 334
• Main Authors: Garcia-Dios, Diego A, Lambrechts, Diether, Coenegrachts, Lieve, Vandenput, Ingrid, Capoen, An, Webb, Penelope M, Ferguson, Kaltin, ANECS, Akslen, Lars A, Claes, Bart, Vergote, Ignace, Moerman, Philippe, Van Robays, Johan, Marcickiewicz, Janusz, Salvesen, Helga B, Spurdle, Amanda B, Amant, Frédéric
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2013
• Subjects: Aged; Biomarkers, Tumor - genetics; Cancer and Oncology; Cancer och onkologi; Carcinoma, Endometrioid - genetics; Carcinoma, Endometrioid - pathology; Cell Cycle Proteins - genetics; Class I Phosphatidylinositol 3-Kinases; Clinical molecular genetics; DNA, Neoplasm - chemistry; DNA, Neoplasm - genetics; Endometrial cancer; Endometrial Neoplasms - genetics; Endometrial Neoplasms - pathology; F-Box Proteins - genetics; F-Box-WD Repeat-Containing Protein 7; Female; Hematology, Oncology and Palliative Medicine; High-Throughput Nucleotide Sequencing; Humans; Middle Aged; Molecular biomarkers; Mutation; Neoplasm Grading; Neoplasm Staging; Obstetrics and Gynecology; Obstetrics, Gynecology and Reproductive Medicine; Oncogenes; Phosphatidylinositol 3-Kinases - genetics; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins p21(ras); PTEN Phosphohydrolase - genetics; ras Proteins - genetics; Reproduktionsmedicin och gynekologi; Tumor suppressor genes; Tumor Suppressor Protein p53 - genetics; Ubiquitin-Protein Ligases - genetics; Tumor suppressor genes; Endometrial cancer; Molecular biomarkers; Clinical molecular genetics; Oncogenes

Abstract Objective Endometrial cancer patients may benefit from systemic adjuvant chemotherapy, alone or in combination with targeted therapies. Prognostic and predictive markers are needed, however, to identify patients amenable for these therapies. Methods Primary endometrial tumors were genotyped...