Chronic administration of apple polyphenols ameliorates hyperglycaemia in high-normal and borderline subjects: A randomised, placebo-controlled trial - Shoji, Toshihiko; Yamada, Mitsuhiro; Miura, Tomisato; Nagashima, Kazuaki; Ogura, Kasane; Inagaki, Nobuya; Maeda-Yamamoto, Mari (Diabetes research and clinical practice, 2017)
Keywords: Administration, Oral; Adult; Apple polyphenols; Blood Glucose; Dietary Supplements; Double-Blind Method; Endocrinology & Metabolism; Female; High-normal and borderline diabetes; Humans; Hyperglycemia - blood; Hyperglycemia - drug therapy; Hypoglycemic Agents - administration & dosage; Male; Malus - chemistry; Middle Aged; Oral glucose tolerance test; Plant Extracts - administration & dosage; Polyphenols - administration & dosage; Treatment Outcome; T2DM; Oral glucose tolerance test; ALP; LDL-C; OGTTTotal AUCglucose; DPP-4; ALT; IFG; LPS; HDL-C; LDH; Apple polyphenols; OGTT30-min glucose; PAI-1; HbA1c; BMI; γ-GTP; AST; GLP-1; IL-6; High-normal and borderline diabetes; AP; TC; CVD; HOMA-IR; TG; APC; TNF-α; IGT; OGTT 2-h glucose; NGT; FPG; OGTT; glucagon-like polypeptide-1; alanine aminotransferase; γ-glutamyl transpeptidase; total cholesterol; interleukin-6; the AUC of plasma glucose post-75 g oral glucose tolerance test; impaired fasting glycaemia; dipeptidyl peptidase-4; high-density lipoprotein cholesterol; alkaline phosphatase; tumour necrosis factor-alpha; homeostasis model assessment of insulin resistance; body mass index; lactate dehydrogenase; apple polyphenols; normal glucose tolerance; plasminogen activator inhibitor-1; 2-h post-75 g oral glucose tolerance test; apple procyanidins; fasting plasma glucose; lipopolysaccharide; 30 min post-75 g oral glucose tolerance test; triglyceride; oral glucose tolerance test; low-density lipoprotein cholesterol; impaired glucose tolerance; type 2 diabetes mellitus; haemoglobin A1c; OGTT 30-min glucose; OGTT Total AUCglucose; cardiovascular diseases; aspartate aminotransferase