Prolactin Regulation of Mammary Gland Development

• Published in: Journal of mammary gland biology and neoplasia Vol. 13; no. 1; pp. 13 - 28
• Main Authors: Oakes, Samantha R, Rogers, Renee L, Naylor, Matthew J, Ormandy, Christopher J
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.03.2008; Springer US; Springer Nature B.V
• Subjects: Animals; Cancer Research; Cell differentiation; Cell proliferation; Elf5; Endocrine System; Epithelial cells; Gene expression; Genomic regulatory networks; growth & development; Humans; Mammary cell fate; Mammary gland; Mammary gland development; Mammary Glands, Animal; Mammary Glands, Animal - growth & development; Mammary Glands, Animal - metabolism; Mammary Glands, Human; Mammary Glands, Human - growth & development; Mammary Glands, Human - metabolism; Medicine; Medicine & Public Health; metabolism; Morphogenesis; Oncology; Pituitary; Pregnancy; Progenitor cells; Progesterone; Prolactin; Prolactin - metabolism; Prolactin - secretion; Puberty; Receptors, Prolactin; Receptors, Prolactin - metabolism; secretion; Signal Transduction; Signaling; Signaling; Genomic regulatory networks; Mammary cell fate; Prolactin; Elf5; Mammary gland development
• ISSN: 1083-3021; 1573-7039; 1573-7039
• DOI: 10.1007/s10911-008-9069-5

Mammary morphogenesis is orchestrated with other reproductive events by pituitary-driven changes to the systemic hormone environment, initiating the formation of a mammary ductal network during puberty and the addition of secretory alveoli during pregnancy. Prolactin is the major driver of developme...