The regulatory roles of phosphatases in cancer
The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development a...
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Published in | Oncogene Vol. 33; no. 8; pp. 939 - 953 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
20.02.2014
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Abstract | The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3—kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies. |
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AbstractList | The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3-kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies. |
Author | Lit, L C Melaiu, O Darrington, R S Rudraraju, B Stebbing, J Zhang, H Giamas, G |
Author_xml | – sequence: 1 givenname: J surname: Stebbing fullname: Stebbing, J organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London – sequence: 2 givenname: L C surname: Lit fullname: Lit, L C organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London – sequence: 3 givenname: H surname: Zhang fullname: Zhang, H organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London – sequence: 4 givenname: R S surname: Darrington fullname: Darrington, R S organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London – sequence: 5 givenname: O surname: Melaiu fullname: Melaiu, O organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London – sequence: 6 givenname: B surname: Rudraraju fullname: Rudraraju, B organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London – sequence: 7 givenname: G surname: Giamas fullname: Giamas, G email: g.giamas@imperial.ac.uk organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23503460$$D View this record in MEDLINE/PubMed |
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PublicationYear | 2014 |
Publisher | Nature Publishing Group UK Nature Publishing Group |
Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
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Title | The regulatory roles of phosphatases in cancer |
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