The regulatory roles of phosphatases in cancer

The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development a...

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Published inOncogene Vol. 33; no. 8; pp. 939 - 953
Main Authors Stebbing, J, Lit, L C, Zhang, H, Darrington, R S, Melaiu, O, Rudraraju, B, Giamas, G
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 20.02.2014
Nature Publishing Group
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Abstract The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3—kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies.
AbstractList The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3-kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies.
Author Lit, L C
Melaiu, O
Darrington, R S
Rudraraju, B
Stebbing, J
Zhang, H
Giamas, G
Author_xml – sequence: 1
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  fullname: Stebbing, J
  organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London
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  givenname: L C
  surname: Lit
  fullname: Lit, L C
  organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London
– sequence: 3
  givenname: H
  surname: Zhang
  fullname: Zhang, H
  organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London
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  givenname: R S
  surname: Darrington
  fullname: Darrington, R S
  organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London
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  givenname: O
  surname: Melaiu
  fullname: Melaiu, O
  organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London
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  surname: Rudraraju
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  organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London
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  surname: Giamas
  fullname: Giamas, G
  email: g.giamas@imperial.ac.uk
  organization: Division of Cancer, Department of Surgery and Cancer, Imperial College London
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23503460$$D View this record in MEDLINE/PubMed
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IngestDate Fri Oct 25 00:30:59 EDT 2024
Thu Oct 24 23:50:20 EDT 2024
Thu Oct 10 18:27:33 EDT 2024
Thu Oct 10 16:34:48 EDT 2024
Fri Sep 27 02:37:20 EDT 2024
Sat Nov 02 12:23:26 EDT 2024
Fri Oct 11 20:47:14 EDT 2024
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Issue 8
Keywords solid tumours
cancer
phosphatases
Language English
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OpenAccessLink https://www.nature.com/articles/onc201380.pdf
PMID 23503460
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crossref_primary_10_1038_onc_2013_80
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PublicationDate 2014-02-20
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PublicationDate_xml – month: 02
  year: 2014
  text: 2014-02-20
  day: 20
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PublicationTitle Oncogene
PublicationTitleAbbrev Oncogene
PublicationTitleAlternate Oncogene
PublicationYear 2014
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
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Snippet The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving...
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SubjectTerms 631/45/607
631/67/581
692/699/67
Apoptosis
Cancer
Cell Biology
Cell cycle
Chromosome 10
Esophageal cancer
Human Genetics
Humans
Internal Medicine
Kinases
Medicine
Medicine & Public Health
Neoplasms - classification
Neoplasms - enzymology
Oncology
Phosphatase
Phosphoprotein Phosphatases - metabolism
Post-translation
PTEN protein
review
Tensin
Tumor suppressor genes
Tumors
Title The regulatory roles of phosphatases in cancer
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Volume 33
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