Cost-Effectiveness of Bevacizumab and Ranibizumab for Newly Diagnosed Neovascular Macular Degeneration
Purpose We sought to determine the most cost-effective treatment for patients with newly diagnosed neovascular macular degeneration: monthly or as-needed bevacizumab injections, or monthly or as-needed ranibizumab injections. Design Cost-effectiveness analysis. Participants Hypothetical cohort of 80...
Saved in:
Published in | Ophthalmology (Rochester, Minn.) Vol. 121; no. 4; pp. 936 - 945 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.04.2014
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Purpose We sought to determine the most cost-effective treatment for patients with newly diagnosed neovascular macular degeneration: monthly or as-needed bevacizumab injections, or monthly or as-needed ranibizumab injections. Design Cost-effectiveness analysis. Participants Hypothetical cohort of 80-year-old patients with newly diagnosed neovascular macular degeneration. Methods Using a mathematical model with a 20-year time horizon, we compared the incremental cost-effectiveness of treating a hypothetical cohort of 80-year-old patients with newly diagnosed neovascular macular degeneration using monthly bevacizumab, as-needed bevacizumab, monthly ranibizumab, or as-needed ranibizumab. Data came from the Comparison of Age-related macular degeneration Treatment Trial (CATT), the Medicare Fee Schedule, and the medical literature. Main Outcome Measures Costs, quality-adjusted life-years (QALYs), and incremental costs per QALY gained. Results Compared with as-needed bevacizumab, the incremental cost-effectiveness ratio of monthly bevacizumab is $242 357/QALY. Monthly ranibizumab gains an additional 0.02 QALYs versus monthly bevacizumab at an incremental cost-effectiveness ratio of >$10 million/QALY. As-needed ranibizumab was dominated by monthly bevacizumab, meaning it was more costly and less effective. In sensitivity analyses assuming a willingness to pay of $100 000/QALY, the annual risk of serious vascular events would have to be ≥2.5 times higher with bevacizumab than that observed in the CATT trial for as-needed ranibizumab to have an incremental cost-effectiveness ratio of <$100 000/QALY. In another sensitivity analysis, even if every patient receiving bevacizumab experienced declining vision by 1 category (e.g., from 20/25–20/40 to 20/50–20/80) after 2 years but every patient receiving ranibizumab retained their vision level, as-needed ranibizumab would have an incremental cost-effectiveness ratio of $97 340/QALY. Conclusions Even after considering the potential for differences in risks of serious adverse events and therapeutic effectiveness, bevacizumab confers considerably greater value than ranibizumab for the treatment of neovascular macular degeneration. |
---|---|
AbstractList | We sought to determine the most cost-effective treatment for patients with newly diagnosed neovascular macular degeneration: monthly or as-needed bevacizumab injections, or monthly or as-needed ranibizumab injections.
Cost-effectiveness analysis.
Hypothetical cohort of 80-year-old patients with newly diagnosed neovascular macular degeneration.
Using a mathematical model with a 20-year time horizon, we compared the incremental cost-effectiveness of treating a hypothetical cohort of 80-year-old patients with newly diagnosed neovascular macular degeneration using monthly bevacizumab, as-needed bevacizumab, monthly ranibizumab, or as-needed ranibizumab. Data came from the Comparison of Age-related macular degeneration Treatment Trial (CATT), the Medicare Fee Schedule, and the medical literature.
Costs, quality-adjusted life-years (QALYs), and incremental costs per QALY gained.
Compared with as-needed bevacizumab, the incremental cost-effectiveness ratio of monthly bevacizumab is $24,2 357/QALY. Monthly ranibizumab gains an additional 0.02 QALYs versus monthly bevacizumab at an incremental cost-effectiveness ratio of >$10 million/QALY. As-needed ranibizumab was dominated by monthly bevacizumab, meaning it was more costly and less effective. In sensitivity analyses assuming a willingness to pay of $100,000/QALY, the annual risk of serious vascular events would have to be ≥2.5 times higher with bevacizumab than that observed in the CATT trial for as-needed ranibizumab to have an incremental cost-effectiveness ratio of <$100,000/QALY. In another sensitivity analysis, even if every patient receiving bevacizumab experienced declining vision by 1 category (e.g., from 20/25-20/40 to 20/50-20/80) after 2 years but every patient receiving ranibizumab retained their vision level, as-needed ranibizumab would have an incremental cost-effectiveness ratio of $97,340/QALY.
Even after considering the potential for differences in risks of serious adverse events and therapeutic effectiveness, bevacizumab confers considerably greater value than ranibizumab for the treatment of neovascular macular degeneration. We sought to determine the most cost-effective treatment for patients with newly diagnosed neovascular macular degeneration: monthly or as-needed bevacizumab injections, or monthly or as-needed ranibizumab injections. Cost-effectiveness analysis. Hypothetical cohort of 80-year-old patients with newly diagnosed neovascular macular degeneration. Using a mathematical model with a 20-year time horizon, we compared the incremental cost-effectiveness of treating a hypothetical cohort of 80-year-old patients with newly diagnosed neovascular macular degeneration using monthly bevacizumab, as-needed bevacizumab, monthly ranibizumab, or as-needed ranibizumab. Data came from the Comparison of Age-related macular degeneration Treatment Trial (CATT), the Medicare Fee Schedule, and the medical literature. Costs, quality-adjusted life-years (QALYs), and incremental costs per QALY gained. Compared with as-needed bevacizumab, the incremental cost-effectiveness ratio of monthly bevacizumab is $242 357/QALY. Monthly ranibizumab gains an additional 0.02 QALYs versus monthly bevacizumab at an incremental cost-effectiveness ratio of >$10 million/QALY. As-needed ranibizumab was dominated by monthly bevacizumab, meaning it was more costly and less effective. In sensitivity analyses assuming a willingness to pay of $100 000/QALY, the annual risk of serious vascular events would have to be ≥2.5 times higher with bevacizumab than that observed in the CATT trial for as-needed ranibizumab to have an incremental cost-effectiveness ratio of <$100 000/QALY. In another sensitivity analysis, even if every patient receiving bevacizumab experienced declining vision by 1 category (e.g., from 20/25–20/40 to 20/50–20/80) after 2 years but every patient receiving ranibizumab retained their vision level, as-needed ranibizumab would have an incremental cost-effectiveness ratio of $97 340/QALY. Even after considering the potential for differences in risks of serious adverse events and therapeutic effectiveness, bevacizumab confers considerably greater value than ranibizumab for the treatment of neovascular macular degeneration. Purpose We sought to determine the most cost-effective treatment for patients with newly diagnosed neovascular macular degeneration: monthly or as-needed bevacizumab injections, or monthly or as-needed ranibizumab injections. Design Cost-effectiveness analysis. Participants Hypothetical cohort of 80-year-old patients with newly diagnosed neovascular macular degeneration. Methods Using a mathematical model with a 20-year time horizon, we compared the incremental cost-effectiveness of treating a hypothetical cohort of 80-year-old patients with newly diagnosed neovascular macular degeneration using monthly bevacizumab, as-needed bevacizumab, monthly ranibizumab, or as-needed ranibizumab. Data came from the Comparison of Age-related macular degeneration Treatment Trial (CATT), the Medicare Fee Schedule, and the medical literature. Main Outcome Measures Costs, quality-adjusted life-years (QALYs), and incremental costs per QALY gained. Results Compared with as-needed bevacizumab, the incremental cost-effectiveness ratio of monthly bevacizumab is $242 357/QALY. Monthly ranibizumab gains an additional 0.02 QALYs versus monthly bevacizumab at an incremental cost-effectiveness ratio of >$10 million/QALY. As-needed ranibizumab was dominated by monthly bevacizumab, meaning it was more costly and less effective. In sensitivity analyses assuming a willingness to pay of $100 000/QALY, the annual risk of serious vascular events would have to be ≥2.5 times higher with bevacizumab than that observed in the CATT trial for as-needed ranibizumab to have an incremental cost-effectiveness ratio of <$100 000/QALY. In another sensitivity analysis, even if every patient receiving bevacizumab experienced declining vision by 1 category (e.g., from 20/25–20/40 to 20/50–20/80) after 2 years but every patient receiving ranibizumab retained their vision level, as-needed ranibizumab would have an incremental cost-effectiveness ratio of $97 340/QALY. Conclusions Even after considering the potential for differences in risks of serious adverse events and therapeutic effectiveness, bevacizumab confers considerably greater value than ranibizumab for the treatment of neovascular macular degeneration. |
Author | Lee, Paul P., MD, JD Newman-Casey, Paula Anne, MD, MS Stein, Joshua D., MD, MS Hutton, David W., PhD Mrinalini, Tavag, MPH |
AuthorAffiliation | 1 Department of Ophthalmology and Visual Sciences, University of Michigan; Ann Arbor, MI 2 Department of Health Management and Policy, University of Michigan; Ann Arbor, MI |
AuthorAffiliation_xml | – name: 2 Department of Health Management and Policy, University of Michigan; Ann Arbor, MI – name: 1 Department of Ophthalmology and Visual Sciences, University of Michigan; Ann Arbor, MI |
Author_xml | – sequence: 1 fullname: Stein, Joshua D., MD, MS – sequence: 2 fullname: Newman-Casey, Paula Anne, MD, MS – sequence: 3 fullname: Mrinalini, Tavag, MPH – sequence: 4 fullname: Lee, Paul P., MD, JD – sequence: 5 fullname: Hutton, David W., PhD |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24405740$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkdtuEzEQhi1URNPCGyC0L7DBs_bamxskSAutVEDicG1NvLOJw8aO7M2i8PR4lVION1yNZjz_P55vLtiZD54Yew58DhzUy-087DfDBucVB5FLcy70IzaDWi5KqUGcsVlug1LJip-zi5S2nHOlhHzCzispea0ln7FuGdJQXncd2cGN5CmlInTFGxrRuh-HHa4K9G3xCb1b3eddiMUH-t4fiyuHax8StTkPIyZ76DEW7_EUr2id_SIOLvin7HGHfaJn9_GSfX17_WV5U959fHe7fH1X2hqaoRQkAFTbaIWiA0uqXtQoGt6irWvAtrKtbmClK8WlUBVy1ABohZXQgK47cclenXz3h9WOWkt-iNibfXQ7jEcT0Jm_X7zbmHUYjQS-0JXOBvJkYGNIKVL3oAVuJu5ma07czcR9qmbuWfbiz7kPol-gf3-M8vajo2iSdeQttS5m9KYN7n8T_jWwvfPOYv-NjpS24RB9JmvApMpw83m6_XR6EBwyrIX4CXpGrrg |
CitedBy_id | crossref_primary_10_1016_j_ajo_2020_05_029 crossref_primary_10_3928_23258160_20150304_01 crossref_primary_10_1021_acs_molpharmaceut_5b00775 crossref_primary_10_1007_s00106_023_01325_7 crossref_primary_10_18553_jmcp_2018_24_2_a_s3 crossref_primary_10_3389_fmed_2021_712511 crossref_primary_10_1177_2474126417725946 crossref_primary_10_1080_17469899_2020_1735363 crossref_primary_10_1177_1120672119863306 crossref_primary_10_1002_14651858_CD005139_pub3 crossref_primary_10_1002_14651858_CD005139_pub4 crossref_primary_10_1016_j_ophtha_2015_03_017 crossref_primary_10_1136_bjophthalmol_2014_306543 crossref_primary_10_1007_s00417_022_05952_8 crossref_primary_10_1111_aos_13824 crossref_primary_10_1111_aos_13706 crossref_primary_10_1080_09286586_2024_2310854 crossref_primary_10_1377_hlthaff_2013_0832 crossref_primary_10_3892_etm_2018_6305 crossref_primary_10_1007_s40273_015_0347_y crossref_primary_10_1001_jamaophthalmol_2021_0144 crossref_primary_10_1167_tvst_9_7_49 crossref_primary_10_18553_jmcp_2022_28_12_1350 crossref_primary_10_2217_pgs_2017_0183 crossref_primary_10_1007_s10792_021_02171_8 crossref_primary_10_1016_j_ajo_2017_10_010 crossref_primary_10_1016_j_jfo_2016_01_007 crossref_primary_10_1016_j_oret_2017_12_006 crossref_primary_10_1586_17469899_2015_1057506 crossref_primary_10_1371_journal_pone_0197670 crossref_primary_10_1097_IAE_0000000000000690 crossref_primary_10_1136_bmjopen_2014_005094 crossref_primary_10_1016_j_ophtha_2019_09_024 crossref_primary_10_1097_IJG_0000000000000772 crossref_primary_10_1016_j_jcjo_2017_04_016 crossref_primary_10_1377_hlthaff_2014_1032 crossref_primary_10_1586_17469899_2015_1005075 crossref_primary_10_1016_j_ajo_2023_06_002 crossref_primary_10_1155_2017_6145651 crossref_primary_10_1080_09286586_2020_1792938 crossref_primary_10_1007_s40258_016_0275_9 crossref_primary_10_1016_j_ophtha_2015_09_002 crossref_primary_10_1136_bjophthalmol_2014_305702 crossref_primary_10_1136_bjophthalmol_2014_306319 crossref_primary_10_18553_jmcp_2018_24_7_608 crossref_primary_10_1016_j_ajo_2017_07_022 crossref_primary_10_1177_0272989X231197772 crossref_primary_10_1016_j_ophtha_2020_06_012 crossref_primary_10_1097_IAE_0000000000001431 crossref_primary_10_18553_jmcp_2018_17416 crossref_primary_10_3390_ijms241613004 crossref_primary_10_1017_bca_2022_12 crossref_primary_10_1007_s00717_017_0384_3 crossref_primary_10_1016_j_ophtha_2015_08_007 crossref_primary_10_1016_j_jcjo_2023_03_005 crossref_primary_10_1136_bjophthalmol_2015_308319 crossref_primary_10_1016_j_ophtha_2018_07_028 crossref_primary_10_1016_j_joco_2017_01_005 |
Cites_doi | 10.1001/archopht.122.4.564 10.1016/S0161-6420(98)96000-6 10.3310/hta12160 10.1016/j.ophtha.2012.04.015 10.1136/bjo.2005.086595 10.1001/archopht.1995.01100120009001 10.1016/S0161-6420(01)00764-3 10.1136/bjo.2007.116616 10.2146/ajhp060388 10.1016/j.ophtha.2008.07.018 10.1160/TH12-03-0162 10.1038/gim.2012.139 10.1016/j.ophtha.2012.03.053 10.1111/j.1524-4733.2007.00283.x 10.2165/00019053-200725100-00005 10.1200/JCO.2003.10.066 10.1111/j.1365-2753.2010.01546.x 10.1001/archopht.1991.01080080069030 10.1007/s00417-009-1156-9 10.7326/0003-4819-154-1-201101040-00289 10.1016/j.ajo.2005.04.061 10.1016/S0161-6420(00)00169-X 10.1001/archinte.163.14.1637 10.1186/1478-7547-6-12 10.1016/S0161-6420(92)31871-8 10.1016/j.ophtha.2007.06.006 10.1056/NEJMoa1102673 10.1016/j.ophtha.2006.09.019 10.1001/archopht.125.4.544 10.1136/bjo.2003.023986 10.1056/NEJMoa062655 10.1016/S0039-6257(02)00457-5 10.1016/S0161-6420(02)01060-6 10.2165/11585520-000000000-00000 10.1097/00006982-200306000-00001 10.3310/hta7090 10.1200/JCO.2005.81.908 10.1056/NEJMoa054481 10.1001/archopht.1982.01030030920003 10.1136/bjo.2003.039131 10.1111/j.1755-3768.2011.02240.x 10.1016/j.ophtha.2007.08.033 |
ContentType | Journal Article |
Copyright | American Academy of Ophthalmology 2014 American Academy of Ophthalmology Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. 2013 American Academy of Ophthalmology, Inc. Published by Elsevier Inc. All rights reserved. 2013 |
Copyright_xml | – notice: American Academy of Ophthalmology – notice: 2014 American Academy of Ophthalmology – notice: Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. – notice: 2013 American Academy of Ophthalmology, Inc. Published by Elsevier Inc. All rights reserved. 2013 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 5PM |
DOI | 10.1016/j.ophtha.2013.10.037 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1549-4713 |
EndPage | 945 |
ExternalDocumentID | 10_1016_j_ophtha_2013_10_037 24405740 S0161642013010439 1_s2_0_S0161642013010439 |
Genre | Comparative Study Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: National Institute of Diabetes and Digestive and Kidney Diseases grantid: 1K23EY019511-01; P30DK092926 – fundername: Research to Prevent Blindness – fundername: NEI NIH HHS grantid: K12 EY022299 – fundername: NIDDK NIH HHS grantid: P30 DK092926 – fundername: NEI NIH HHS grantid: K23 EY019511 – fundername: NEI NIH HHS grantid: K23 1K23EY019511-01 – fundername: NIDDK NIH HHS grantid: P30DK092926 |
GroupedDBID | --- --K .1- .55 .FO .GJ 0R~ 123 1B1 1P~ 1~5 29N 4.4 457 4G. 53G 5RE 5VS 7-5 71M AAEDT AAEDW AALRI AAQFI AAQQT AAQXK AAXUO ABCQX ABFRF ABJNI ABLJU ABMAC ABOCM ACGFO ACGFS ACIUM ACNCT ADMUD ADPAM AEFWE AENEX AEVXI AFFNX AFJKZ AFRHN AFTJW AITUG AJUYK AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ BELOY C5W CS3 DU5 EBS EFJIC EJD F5P FDB FEDTE FGOYB GBLVA HVGLF HZ~ IHE J1W K-O KOM L7B M27 M41 MO0 N4W N9A NQ- O9- OF- OPF OQ~ P2P R2- RIG ROL RPZ SDG SEL SES SSZ UHS UNMZH UV1 WH7 X7M XH2 XPP Z5R ZGI ZXP AAIAV AGZHU AHPSJ ALXNB ZA5 CGR CUY CVF ECM EIF NPM AAYXX CITATION 5PM |
ID | FETCH-LOGICAL-c518t-3e3116d876a3f1ce6595a380dac551ad2cd781b72604362a0a711ac3c418175f3 |
ISSN | 0161-6420 |
IngestDate | Tue Sep 17 21:26:19 EDT 2024 Thu Sep 26 16:15:28 EDT 2024 Sat Sep 28 07:57:13 EDT 2024 Fri Feb 23 02:14:13 EST 2024 Tue Oct 15 22:54:46 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Language | English |
License | Copyright © 2014 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c518t-3e3116d876a3f1ce6595a380dac551ad2cd781b72604362a0a711ac3c418175f3 |
OpenAccessLink | https://europepmc.org/articles/pmc4109727?pdf=render |
PMID | 24405740 |
PageCount | 10 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4109727 crossref_primary_10_1016_j_ophtha_2013_10_037 pubmed_primary_24405740 elsevier_sciencedirect_doi_10_1016_j_ophtha_2013_10_037 elsevier_clinicalkeyesjournals_1_s2_0_S0161642013010439 |
PublicationCentury | 2000 |
PublicationDate | 2014-04-01 |
PublicationDateYYYYMMDD | 2014-04-01 |
PublicationDate_xml | – month: 04 year: 2014 text: 2014-04-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Ophthalmology (Rochester, Minn.) |
PublicationTitleAlternate | Ophthalmology |
PublicationYear | 2014 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Javitt, Zlateva, Earnshaw (bib16) 2008; 11 Fletcher, Lade, Adewoyin, Chong (bib22) 2008; 115 Larouche, Rochon, Wickens (bib45) 2005 Martin, Maguire, Fine (bib12) 2012; 119 Carneiro AM, Costa R, Falcão MS, et al. Vascular endothelial growth factor plasma levels before and after treatment of neovascular age-related macular degeneration with bevacizumab or ranibizumab [report online]. Acta Ophthalmol 2012;90:e25-30. Available at Dooren JC, Whalen J. Study compares Lucentis, Avastin. The Wall Street Journal. April 28, 2011. Klein, Klein, Linton (bib3) 1992; 99 Raftery, Clegg, Jones (bib25) 2007; 91 (bib7) 1991; 109 Accessed October 20, 2013. (bib19) 2008 Brown, Brown, Brown, Peet (bib18) 2008; 115 Shah, Ilson, Kelsen (bib53) 2005; 23 Colquitt, Jones, Tan (bib15) 2008; 12 Frick, Gower, Kempen, Wolff (bib33) 2007; 125 Red Book Drug References [database]. Truven Health Analytics Inc. Busbee, Brown, Brown, Sharma (bib44) 2003; 23 Sharma, Brown, Brown (bib49) 2001; 108 (bib32) 2012 Freeman, Zhu, Owens (bib36) 2011; 154 Lalwani, Flynn, Scott (bib30) 2008; 115 Hurley, Matthews, Guymer (bib20) 2008; 6 Hassell, Lamoureux, Keeffe (bib4) 2006; 90 Aaberg, Flynn, Schiffman, Newton (bib38) 1998; 105 Bajaj, Veenstra (bib39) 2013; 15 (bib6) 1982; 100 Ubel, Hirth, Chernew, Fendrick (bib42) 2003; 163 Recent publicly-funded CATT trial highlights serious safety concerns around unlicensed ocular bevacizumab use versus Lucentis [press release]. Basel, Switzerland: Novartis; May 1, 2012. Available from Brown, Brown, Sharma (bib43) 2000; 107 (bib2) 2004; 122 Kabbinavar, Hurwitz, Fehrenbacher (bib52) 2003; 21 Accessed August 22, 2013. Scilley, Jackson, Cideciyan (bib5) 2002; 109 Smith, Fenn, Drummond (bib14) 2004; 88 (bib31) 1995; 113 (bib41) 1996 Brown, Hodge, Kymes (bib21) 2008 (bib11) 2011; 364 MacDougall, Feliu, Boccuzzi, Lin (bib35) 2006; 63 Wormald, Evans, Smeeth, Henshaw (bib8) 2005 Drummond, Sculpher, Torrance (bib29) 2005 IVAN Study Investigators, Chakravarthy, Harding, Rogers (bib50) 2012; 119 Brown, Brown, Sharma, Landy (bib37) 2003; 48 Hernandez-Pastor, Ortega, Garcia-Layana, Giraldez (bib23) 2010; 248 Brown, Brown, Brown (bib13) 2007; 114 Mitchell, Annemans, White (bib24) 2011; 29 Medicare payments for drugs used to treat wet age-related macular degeneration (OEI-03-10-00360). Department of Health and Human Services, Office of Inspector General; 2012. Available at National Advisory Eye Council. Vision Research, a National Plan, 1994-1998. Washington, DC: US Department of Health and Human Services; 1993. NIH publication 93–3186. Patel, Mendes, Bounthavong (bib26) 2012; 18 Mahan, Borrego, Woersching (bib34) 2012; 108 Hopley, Salkeld, Mitchell (bib47) 2004; 88 Brown, Kaiser, Michels (bib10) 2006; 355 Brown, Brown, Campanella, Beauchamp (bib46) 2005; 140 Rosenfeld, Brown, Heier (bib9) 2006; 355 Meads, Salas, Roberts (bib48) 2003; 7 Wolowacz, Roskell, Kelly (bib17) 2007; 25 1630784 - Ophthalmology. 1992 Jun;99(6):933-43 1714270 - Arch Ophthalmol. 1991 Aug;109(8):1109-14 16226519 - Am J Ophthalmol. 2005 Oct;140(4):679-87 18930556 - Ophthalmology. 2008 Dec;115(12):2192-8 15078675 - Arch Ophthalmol. 2004 Apr;122(4):564-72 18462575 - Health Technol Assess. 2008 May;12(16):iii-iv, ix-201 16235294 - Cochrane Database Syst Rev. 2005;(4):CD002030 21244102 - Pharmacoeconomics. 2011 Feb;29(2):107-31 10889115 - Ophthalmology. 2000 Jul;107(7):1374-80 17320964 - Ophthalmology. 2007 Jun;114(6):1170-8 9627649 - Ophthalmology. 1998 Jun;105(6):1004-10 17420375 - Arch Ophthalmol. 2007 Apr;125(4):544-50 17021318 - N Engl J Med. 2006 Oct 5;355(14):1419-31 12093644 - Ophthalmology. 2002 Jul;109(7):1235-42 22578446 - Ophthalmology. 2012 Jul;119(7):1399-411 17032933 - Am J Health Syst Pharm. 2006 Oct 15;63(20 Suppl 6):S5-15 15795413 - J Clin Oncol. 2005 Apr 10;23(11):2574-6 7046707 - Arch Ophthalmol. 1982 Jun;100(6):912-8 12686305 - Surv Ophthalmol. 2003 Mar-Apr;48(2):204-23 21041570 - Ann Intern Med. 2011 Jan 4;154(1):1-11 17021319 - N Engl J Med. 2006 Oct 5;355(14):1432-44 12506171 - J Clin Oncol. 2003 Jan 1;21(1):60-5 23138100 - Genet Med. 2013 May;15(5):374-81 22739656 - Thromb Haemost. 2012 Aug;108(2):291-302 7487614 - Arch Ophthalmol. 1995 Dec;113(12):1479-96 12824826 - Retina. 2003 Jun;23(3):279-87; ; quiz 443-4 12885677 - Arch Intern Med. 2003 Jul 28;163(14):1637-41 20846318 - J Eval Clin Pract. 2012 Apr;18(2):247-55 17887807 - Pharmacoeconomics. 2007;25(10):863-79 18067969 - Ophthalmology. 2008 Mar;115(3):473-6 19669678 - Graefes Arch Clin Exp Ophthalmol. 2010 Apr;248(4):467-76 12709292 - Health Technol Assess. 2003;7(9):v-vi, 1-98 15317697 - Br J Ophthalmol. 2004 Sep;88(9):1107-12 21526923 - N Engl J Med. 2011 May 19;364(20):1897-908 15258009 - Br J Ophthalmol. 2004 Aug;88(8):982-7 22555112 - Ophthalmology. 2012 Jul;119(7):1388-98 18573218 - Cost Eff Resour Alloc. 2008 Jun 24;6:12 17976724 - Ophthalmology. 2008 Jun;115(6):1039-1045.e5 11713079 - Ophthalmology. 2001 Nov;108(11):2051-9 18179676 - Value Health. 2008 Jul-Aug;11(4):563-74 21958440 - Acta Ophthalmol. 2012 Feb;90(1):e25-30 16622089 - Br J Ophthalmol. 2006 May;90(5):593-6 17431015 - Br J Ophthalmol. 2007 Sep;91(9):1244-6 Wormald (10.1016/j.ophtha.2013.10.037_bib8) 2005 10.1016/j.ophtha.2013.10.037_bib54 10.1016/j.ophtha.2013.10.037_bib51 Shah (10.1016/j.ophtha.2013.10.037_bib53) 2005; 23 Colquitt (10.1016/j.ophtha.2013.10.037_bib15) 2008; 12 (10.1016/j.ophtha.2013.10.037_bib6) 1982; 100 Hurley (10.1016/j.ophtha.2013.10.037_bib20) 2008; 6 IVAN Study Investigators (10.1016/j.ophtha.2013.10.037_bib50) 2012; 119 Brown (10.1016/j.ophtha.2013.10.037_bib43) 2000; 107 Hopley (10.1016/j.ophtha.2013.10.037_bib47) 2004; 88 Meads (10.1016/j.ophtha.2013.10.037_bib48) 2003; 7 (10.1016/j.ophtha.2013.10.037_bib19) 2008 Busbee (10.1016/j.ophtha.2013.10.037_bib44) 2003; 23 Fletcher (10.1016/j.ophtha.2013.10.037_bib22) 2008; 115 Aaberg (10.1016/j.ophtha.2013.10.037_bib38) 1998; 105 (10.1016/j.ophtha.2013.10.037_bib31) 1995; 113 Hassell (10.1016/j.ophtha.2013.10.037_bib4) 2006; 90 Brown (10.1016/j.ophtha.2013.10.037_bib18) 2008; 115 Kabbinavar (10.1016/j.ophtha.2013.10.037_bib52) 2003; 21 Smith (10.1016/j.ophtha.2013.10.037_bib14) 2004; 88 10.1016/j.ophtha.2013.10.037_bib28 10.1016/j.ophtha.2013.10.037_bib27 Drummond (10.1016/j.ophtha.2013.10.037_bib29) 2005 Brown (10.1016/j.ophtha.2013.10.037_bib21) 2008 Scilley (10.1016/j.ophtha.2013.10.037_bib5) 2002; 109 Freeman (10.1016/j.ophtha.2013.10.037_bib36) 2011; 154 MacDougall (10.1016/j.ophtha.2013.10.037_bib35) 2006; 63 Rosenfeld (10.1016/j.ophtha.2013.10.037_bib9) 2006; 355 (10.1016/j.ophtha.2013.10.037_bib11) 2011; 364 Sharma (10.1016/j.ophtha.2013.10.037_bib49) 2001; 108 Javitt (10.1016/j.ophtha.2013.10.037_bib16) 2008; 11 Lalwani (10.1016/j.ophtha.2013.10.037_bib30) 2008; 115 Brown (10.1016/j.ophtha.2013.10.037_bib37) 2003; 48 (10.1016/j.ophtha.2013.10.037_bib41) 1996 Patel (10.1016/j.ophtha.2013.10.037_bib26) 2012; 18 Wolowacz (10.1016/j.ophtha.2013.10.037_bib17) 2007; 25 Mitchell (10.1016/j.ophtha.2013.10.037_bib24) 2011; 29 (10.1016/j.ophtha.2013.10.037_bib32) 2012 Klein (10.1016/j.ophtha.2013.10.037_bib3) 1992; 99 Brown (10.1016/j.ophtha.2013.10.037_bib46) 2005; 140 (10.1016/j.ophtha.2013.10.037_bib2) 2004; 122 10.1016/j.ophtha.2013.10.037_bib1 10.1016/j.ophtha.2013.10.037_bib40 Brown (10.1016/j.ophtha.2013.10.037_bib10) 2006; 355 Raftery (10.1016/j.ophtha.2013.10.037_bib25) 2007; 91 Ubel (10.1016/j.ophtha.2013.10.037_bib42) 2003; 163 Mahan (10.1016/j.ophtha.2013.10.037_bib34) 2012; 108 Larouche (10.1016/j.ophtha.2013.10.037_bib45) 2005 Bajaj (10.1016/j.ophtha.2013.10.037_bib39) 2013; 15 Martin (10.1016/j.ophtha.2013.10.037_bib12) 2012; 119 Hernandez-Pastor (10.1016/j.ophtha.2013.10.037_bib23) 2010; 248 Frick (10.1016/j.ophtha.2013.10.037_bib33) 2007; 125 (10.1016/j.ophtha.2013.10.037_bib7) 1991; 109 Brown (10.1016/j.ophtha.2013.10.037_bib13) 2007; 114 |
References_xml | – start-page: CD002030 year: 2005 ident: bib8 article-title: Photodynamic therapy for neovascular age-related macular degeneration publication-title: Cochrane Database Syst Rev contributor: fullname: Henshaw – volume: 364 start-page: 1897 year: 2011 end-page: 1908 ident: bib11 article-title: Ranibizumab and bevacizumab for neovascular age-related macular degeneration publication-title: N Engl J Med – volume: 248 start-page: 467 year: 2010 end-page: 476 ident: bib23 article-title: Cost-effectiveness of ranibizumab compared with pegaptanib in neovascular age-related macular degeneration publication-title: Graefes Arch Clin Exp Ophthalmol contributor: fullname: Giraldez – volume: 23 start-page: 2574 year: 2005 end-page: 2576 ident: bib53 article-title: Thromboembolic events in gastric cancer: high incidence in patients receiving irinotecan- and bevacizumab-based therapy [letter] publication-title: J Clin Oncol contributor: fullname: Kelsen – volume: 23 start-page: 279 year: 2003 end-page: 287 ident: bib44 article-title: CME review: a cost-utility analysis of laser photocoagulation for extrafoveal choroidal neovascularization publication-title: Retina contributor: fullname: Sharma – volume: 25 start-page: 863 year: 2007 end-page: 879 ident: bib17 article-title: Cost effectiveness of pegaptanib for the treatment of age-related macular degeneration in the UK publication-title: Pharmacoeconomics contributor: fullname: Kelly – volume: 18 start-page: 247 year: 2012 end-page: 255 ident: bib26 article-title: Cost-utility analysis of bevacizumab versus ranibizumab in neovascular age-related macular degeneration using a Markov model publication-title: J Eval Clin Pract contributor: fullname: Bounthavong – year: 2008 ident: bib21 article-title: Management of neovascular age-related macular degeneration: systematic drug class review and economic evaluation [technology report number 110] contributor: fullname: Kymes – volume: 90 start-page: 593 year: 2006 end-page: 596 ident: bib4 article-title: Impact of age related macular degeneration on quality of life publication-title: Br J Ophthalmol contributor: fullname: Keeffe – volume: 108 start-page: 291 year: 2012 end-page: 302 ident: bib34 article-title: Venous thromboembolism: annualised United States models for total, hospital-acquired and preventable costs utilising long-term attack rates publication-title: Thromb Haemost contributor: fullname: Woersching – volume: 7 year: 2003 ident: bib48 article-title: Clinical effectiveness and cost-utility of photodynamic therapy for wet age-related macular degeneration: a systematic review and economic evaluation publication-title: Health Technol Assess contributor: fullname: Roberts – volume: 11 start-page: 563 year: 2008 end-page: 574 ident: bib16 article-title: Cost-effectiveness model for neovascular age-related macular degeneration: comparing early and late treatment with pegaptanib sodium based on visual acuity publication-title: Value Health contributor: fullname: Earnshaw – volume: 15 start-page: 374 year: 2013 end-page: 381 ident: bib39 article-title: A risk–benefit analysis of factor V Leiden testing to improve pregnancy outcomes: a case study of the capabilities of decision modeling in genomics publication-title: Genet Med contributor: fullname: Veenstra – volume: 107 start-page: 1374 year: 2000 end-page: 1380 ident: bib43 article-title: Incremental cost effectiveness of laser photocoagulation for subfoveal choroidal neovascularization publication-title: Ophthalmology contributor: fullname: Sharma – year: 2005 ident: bib45 article-title: translator. Evaluation of photodynamic therapy for the treatment of exudative age-related macular degeneration (ARMD) with subfoveal neovascularization contributor: fullname: Wickens – volume: 355 start-page: 1419 year: 2006 end-page: 1431 ident: bib9 article-title: MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration publication-title: N Engl J Med contributor: fullname: Heier – volume: 91 start-page: 1244 year: 2007 end-page: 1246 ident: bib25 article-title: Ranibizumab (Lucentis) versus Bevacizumab (Avastin): modelling cost effectiveness publication-title: Br J Ophthalmol contributor: fullname: Jones – volume: 125 start-page: 544 year: 2007 end-page: 550 ident: bib33 article-title: Economic impact of visual impairment and blindness in the United States publication-title: Arch Ophthalmol contributor: fullname: Wolff – volume: 154 start-page: 1 year: 2011 end-page: 11 ident: bib36 article-title: Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation publication-title: Ann Intern Med contributor: fullname: Owens – volume: 140 start-page: 679 year: 2005 end-page: 687 ident: bib46 article-title: The cost-utility of photodynamic therapy in eyes with neovascular macular degeneration–a value-based reappraisal with 5-year data publication-title: Am J Ophthalmol contributor: fullname: Beauchamp – volume: 163 start-page: 1637 year: 2003 end-page: 1641 ident: bib42 article-title: What is the price of life and why doesn't it increase at the rate of inflation? publication-title: Arch Intern Med contributor: fullname: Fendrick – volume: 109 start-page: 1109 year: 1991 end-page: 1114 ident: bib7 article-title: Argon laser photocoagulation for neovascular maculopathy. Five-year results from randomized clinical trials publication-title: Arch Ophthalmol – volume: 355 start-page: 1432 year: 2006 end-page: 1444 ident: bib10 article-title: ANCHOR Study Group. Ranibizumab versus verteporfin for neovascular age-related macular degeneration publication-title: N Engl J Med contributor: fullname: Michels – volume: 29 start-page: 107 year: 2011 end-page: 131 ident: bib24 article-title: Cost effectiveness of treatments for wet age-related macular degeneration publication-title: Pharmacoeconomics contributor: fullname: White – volume: 99 start-page: 933 year: 1992 end-page: 943 ident: bib3 article-title: Prevalence of age-related maculopathy: the Beaver Dam Eye Study publication-title: Ophthalmology contributor: fullname: Linton – volume: 21 start-page: 60 year: 2003 end-page: 65 ident: bib52 article-title: Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer publication-title: J Clin Oncol contributor: fullname: Fehrenbacher – volume: 6 start-page: 12 year: 2008 ident: bib20 article-title: Cost-effectiveness of ranibizumab for neovascular age-related macular degeneration publication-title: Cost Eff Resour Alloc [serial online] contributor: fullname: Guymer – volume: 63 start-page: S5 year: 2006 end-page: 15 ident: bib35 article-title: Economic burden of deep-vein thrombosis, pulmonary embolism, and post-thrombotic syndrome publication-title: Am J Health Syst Pharm contributor: fullname: Lin – volume: 115 start-page: 1039 year: 2008 end-page: 1045 ident: bib18 article-title: A value-based medicine analysis of ranibizumab for the treatment of subfoveal neovascular macular degeneration publication-title: Ophthalmology contributor: fullname: Peet – year: 1996 ident: bib41 publication-title: Cost-Effectiveness in Health and Medicine – volume: 88 start-page: 982 year: 2004 end-page: 987 ident: bib47 article-title: Cost utility of photodynamic therapy for predominantly classic neovascular age related macular degeneration publication-title: Br J Ophthalmol contributor: fullname: Mitchell – volume: 109 start-page: 1235 year: 2002 end-page: 1242 ident: bib5 article-title: Early age-related maculopathy and self-reported visual difficulty in daily life publication-title: Ophthalmology contributor: fullname: Cideciyan – volume: 88 start-page: 1107 year: 2004 end-page: 1112 ident: bib14 article-title: Cost effectiveness of photodynamic therapy with verteporfin for age related macular degeneration: the UK case publication-title: Br J Ophthalmol contributor: fullname: Drummond – volume: 48 start-page: 204 year: 2003 end-page: 223 ident: bib37 article-title: Health care economic analyses and value-based medicine publication-title: Surv Ophthalmol contributor: fullname: Landy – volume: 108 start-page: 2051 year: 2001 end-page: 2059 ident: bib49 article-title: The cost-effectiveness of photodynamic therapy for fellow eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration publication-title: Ophthalmology contributor: fullname: Brown – volume: 122 start-page: 564 year: 2004 end-page: 572 ident: bib2 article-title: Prevalence of age-related macular degeneration in the United States publication-title: Arch Ophthalmol – volume: 119 start-page: 1399 year: 2012 end-page: 1411 ident: bib50 article-title: Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial publication-title: Ophthalmology contributor: fullname: Rogers – volume: 12 year: 2008 ident: bib15 article-title: Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: a systematic review and economic evaluation publication-title: Health Technol Assess contributor: fullname: Tan – volume: 114 start-page: 1170 year: 2007 end-page: 1178 ident: bib13 article-title: A value-based medicine comparison of interventions for subfoveal neovascular macular degeneration publication-title: Ophthalmology contributor: fullname: Brown – volume: 115 start-page: 2192 year: 2008 end-page: 2198 ident: bib22 article-title: Computerized model of cost-utility analysis for treatment of age-related macular degeneration publication-title: Ophthalmology contributor: fullname: Chong – volume: 105 start-page: 1004 year: 1998 end-page: 1010 ident: bib38 article-title: Nosocomial acute-onset postoperative endophthalmitis surgery. A 10-year review of incidence and outcomes publication-title: Ophthalmology contributor: fullname: Newton – year: 2012 ident: bib32 article-title: CDC WONDER. Underlying Cause of Death, 1999-2010 [database online] publication-title: Revised – year: 2005 ident: bib29 article-title: Methods for the Economic Evaluation of Health Care Programmes contributor: fullname: Torrance – volume: 115 start-page: 473 year: 2008 end-page: 476 ident: bib30 article-title: Acute-onset endophthalmitis after clear corneal cataract surgery (1996–2005): clinical features, causative organisms, and visual acuity outcomes publication-title: Ophthalmology contributor: fullname: Scott – volume: 119 start-page: 1388 year: 2012 end-page: 1398 ident: bib12 article-title: Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results publication-title: Ophthalmology contributor: fullname: Fine – volume: 100 start-page: 912 year: 1982 end-page: 918 ident: bib6 article-title: Argon laser photocoagulation for senile macular degeneration. Results of a randomized clinical trial publication-title: Arch Ophthalmol – year: 2008 ident: bib19 article-title: Overview of CDR clinical and pharmacoeconomic reports. Ranibizumab (Lucentis–Novartis Pharmaceuticals Canada Inc), Indication–age-related macular degeneration (AMD) – volume: 113 start-page: 1479 year: 1995 end-page: 1496 ident: bib31 article-title: Results of the Endophthalmitis Vitrectomy Study: a randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis publication-title: Arch Ophthalmol – volume: 122 start-page: 564 year: 2004 ident: 10.1016/j.ophtha.2013.10.037_bib2 article-title: Prevalence of age-related macular degeneration in the United States publication-title: Arch Ophthalmol doi: 10.1001/archopht.122.4.564 – volume: 105 start-page: 1004 year: 1998 ident: 10.1016/j.ophtha.2013.10.037_bib38 article-title: Nosocomial acute-onset postoperative endophthalmitis surgery. A 10-year review of incidence and outcomes publication-title: Ophthalmology doi: 10.1016/S0161-6420(98)96000-6 contributor: fullname: Aaberg – volume: 12 year: 2008 ident: 10.1016/j.ophtha.2013.10.037_bib15 article-title: Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: a systematic review and economic evaluation publication-title: Health Technol Assess doi: 10.3310/hta12160 contributor: fullname: Colquitt – volume: 119 start-page: 1399 year: 2012 ident: 10.1016/j.ophtha.2013.10.037_bib50 article-title: Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial publication-title: Ophthalmology doi: 10.1016/j.ophtha.2012.04.015 contributor: fullname: IVAN Study Investigators – volume: 90 start-page: 593 year: 2006 ident: 10.1016/j.ophtha.2013.10.037_bib4 article-title: Impact of age related macular degeneration on quality of life publication-title: Br J Ophthalmol doi: 10.1136/bjo.2005.086595 contributor: fullname: Hassell – volume: 113 start-page: 1479 year: 1995 ident: 10.1016/j.ophtha.2013.10.037_bib31 article-title: Results of the Endophthalmitis Vitrectomy Study: a randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis publication-title: Arch Ophthalmol doi: 10.1001/archopht.1995.01100120009001 – volume: 108 start-page: 2051 year: 2001 ident: 10.1016/j.ophtha.2013.10.037_bib49 article-title: The cost-effectiveness of photodynamic therapy for fellow eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration publication-title: Ophthalmology doi: 10.1016/S0161-6420(01)00764-3 contributor: fullname: Sharma – volume: 91 start-page: 1244 year: 2007 ident: 10.1016/j.ophtha.2013.10.037_bib25 article-title: Ranibizumab (Lucentis) versus Bevacizumab (Avastin): modelling cost effectiveness publication-title: Br J Ophthalmol doi: 10.1136/bjo.2007.116616 contributor: fullname: Raftery – volume: 63 start-page: S5 issue: suppl year: 2006 ident: 10.1016/j.ophtha.2013.10.037_bib35 article-title: Economic burden of deep-vein thrombosis, pulmonary embolism, and post-thrombotic syndrome publication-title: Am J Health Syst Pharm doi: 10.2146/ajhp060388 contributor: fullname: MacDougall – volume: 115 start-page: 2192 year: 2008 ident: 10.1016/j.ophtha.2013.10.037_bib22 article-title: Computerized model of cost-utility analysis for treatment of age-related macular degeneration publication-title: Ophthalmology doi: 10.1016/j.ophtha.2008.07.018 contributor: fullname: Fletcher – ident: 10.1016/j.ophtha.2013.10.037_bib28 – volume: 108 start-page: 291 year: 2012 ident: 10.1016/j.ophtha.2013.10.037_bib34 article-title: Venous thromboembolism: annualised United States models for total, hospital-acquired and preventable costs utilising long-term attack rates publication-title: Thromb Haemost doi: 10.1160/TH12-03-0162 contributor: fullname: Mahan – volume: 15 start-page: 374 year: 2013 ident: 10.1016/j.ophtha.2013.10.037_bib39 article-title: A risk–benefit analysis of factor V Leiden testing to improve pregnancy outcomes: a case study of the capabilities of decision modeling in genomics publication-title: Genet Med doi: 10.1038/gim.2012.139 contributor: fullname: Bajaj – volume: 119 start-page: 1388 year: 2012 ident: 10.1016/j.ophtha.2013.10.037_bib12 article-title: Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results publication-title: Ophthalmology doi: 10.1016/j.ophtha.2012.03.053 contributor: fullname: Martin – volume: 11 start-page: 563 year: 2008 ident: 10.1016/j.ophtha.2013.10.037_bib16 article-title: Cost-effectiveness model for neovascular age-related macular degeneration: comparing early and late treatment with pegaptanib sodium based on visual acuity publication-title: Value Health doi: 10.1111/j.1524-4733.2007.00283.x contributor: fullname: Javitt – volume: 25 start-page: 863 year: 2007 ident: 10.1016/j.ophtha.2013.10.037_bib17 article-title: Cost effectiveness of pegaptanib for the treatment of age-related macular degeneration in the UK publication-title: Pharmacoeconomics doi: 10.2165/00019053-200725100-00005 contributor: fullname: Wolowacz – ident: 10.1016/j.ophtha.2013.10.037_bib1 – year: 2012 ident: 10.1016/j.ophtha.2013.10.037_bib32 article-title: CDC WONDER. Underlying Cause of Death, 1999-2010 [database online] publication-title: Revised – volume: 21 start-page: 60 year: 2003 ident: 10.1016/j.ophtha.2013.10.037_bib52 article-title: Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer publication-title: J Clin Oncol doi: 10.1200/JCO.2003.10.066 contributor: fullname: Kabbinavar – volume: 18 start-page: 247 year: 2012 ident: 10.1016/j.ophtha.2013.10.037_bib26 article-title: Cost-utility analysis of bevacizumab versus ranibizumab in neovascular age-related macular degeneration using a Markov model publication-title: J Eval Clin Pract doi: 10.1111/j.1365-2753.2010.01546.x contributor: fullname: Patel – volume: 109 start-page: 1109 year: 1991 ident: 10.1016/j.ophtha.2013.10.037_bib7 article-title: Argon laser photocoagulation for neovascular maculopathy. Five-year results from randomized clinical trials publication-title: Arch Ophthalmol doi: 10.1001/archopht.1991.01080080069030 – volume: 248 start-page: 467 year: 2010 ident: 10.1016/j.ophtha.2013.10.037_bib23 article-title: Cost-effectiveness of ranibizumab compared with pegaptanib in neovascular age-related macular degeneration publication-title: Graefes Arch Clin Exp Ophthalmol doi: 10.1007/s00417-009-1156-9 contributor: fullname: Hernandez-Pastor – year: 1996 ident: 10.1016/j.ophtha.2013.10.037_bib41 – volume: 154 start-page: 1 year: 2011 ident: 10.1016/j.ophtha.2013.10.037_bib36 article-title: Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in atrial fibrillation publication-title: Ann Intern Med doi: 10.7326/0003-4819-154-1-201101040-00289 contributor: fullname: Freeman – year: 2005 ident: 10.1016/j.ophtha.2013.10.037_bib29 contributor: fullname: Drummond – volume: 140 start-page: 679 year: 2005 ident: 10.1016/j.ophtha.2013.10.037_bib46 article-title: The cost-utility of photodynamic therapy in eyes with neovascular macular degeneration–a value-based reappraisal with 5-year data publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2005.04.061 contributor: fullname: Brown – volume: 107 start-page: 1374 year: 2000 ident: 10.1016/j.ophtha.2013.10.037_bib43 article-title: Incremental cost effectiveness of laser photocoagulation for subfoveal choroidal neovascularization publication-title: Ophthalmology doi: 10.1016/S0161-6420(00)00169-X contributor: fullname: Brown – year: 2005 ident: 10.1016/j.ophtha.2013.10.037_bib45 contributor: fullname: Larouche – year: 2008 ident: 10.1016/j.ophtha.2013.10.037_bib19 – volume: 163 start-page: 1637 year: 2003 ident: 10.1016/j.ophtha.2013.10.037_bib42 article-title: What is the price of life and why doesn't it increase at the rate of inflation? publication-title: Arch Intern Med doi: 10.1001/archinte.163.14.1637 contributor: fullname: Ubel – volume: 6 start-page: 12 year: 2008 ident: 10.1016/j.ophtha.2013.10.037_bib20 article-title: Cost-effectiveness of ranibizumab for neovascular age-related macular degeneration publication-title: Cost Eff Resour Alloc [serial online] doi: 10.1186/1478-7547-6-12 contributor: fullname: Hurley – volume: 99 start-page: 933 year: 1992 ident: 10.1016/j.ophtha.2013.10.037_bib3 article-title: Prevalence of age-related maculopathy: the Beaver Dam Eye Study publication-title: Ophthalmology doi: 10.1016/S0161-6420(92)31871-8 contributor: fullname: Klein – volume: 115 start-page: 473 year: 2008 ident: 10.1016/j.ophtha.2013.10.037_bib30 article-title: Acute-onset endophthalmitis after clear corneal cataract surgery (1996–2005): clinical features, causative organisms, and visual acuity outcomes publication-title: Ophthalmology doi: 10.1016/j.ophtha.2007.06.006 contributor: fullname: Lalwani – volume: 364 start-page: 1897 year: 2011 ident: 10.1016/j.ophtha.2013.10.037_bib11 article-title: Ranibizumab and bevacizumab for neovascular age-related macular degeneration publication-title: N Engl J Med doi: 10.1056/NEJMoa1102673 – volume: 114 start-page: 1170 year: 2007 ident: 10.1016/j.ophtha.2013.10.037_bib13 article-title: A value-based medicine comparison of interventions for subfoveal neovascular macular degeneration publication-title: Ophthalmology doi: 10.1016/j.ophtha.2006.09.019 contributor: fullname: Brown – volume: 125 start-page: 544 year: 2007 ident: 10.1016/j.ophtha.2013.10.037_bib33 article-title: Economic impact of visual impairment and blindness in the United States publication-title: Arch Ophthalmol doi: 10.1001/archopht.125.4.544 contributor: fullname: Frick – volume: 88 start-page: 1107 year: 2004 ident: 10.1016/j.ophtha.2013.10.037_bib14 article-title: Cost effectiveness of photodynamic therapy with verteporfin for age related macular degeneration: the UK case publication-title: Br J Ophthalmol doi: 10.1136/bjo.2003.023986 contributor: fullname: Smith – volume: 355 start-page: 1432 year: 2006 ident: 10.1016/j.ophtha.2013.10.037_bib10 article-title: ANCHOR Study Group. Ranibizumab versus verteporfin for neovascular age-related macular degeneration publication-title: N Engl J Med doi: 10.1056/NEJMoa062655 contributor: fullname: Brown – ident: 10.1016/j.ophtha.2013.10.037_bib51 – year: 2008 ident: 10.1016/j.ophtha.2013.10.037_bib21 contributor: fullname: Brown – volume: 48 start-page: 204 year: 2003 ident: 10.1016/j.ophtha.2013.10.037_bib37 article-title: Health care economic analyses and value-based medicine publication-title: Surv Ophthalmol doi: 10.1016/S0039-6257(02)00457-5 contributor: fullname: Brown – volume: 109 start-page: 1235 year: 2002 ident: 10.1016/j.ophtha.2013.10.037_bib5 article-title: Early age-related maculopathy and self-reported visual difficulty in daily life publication-title: Ophthalmology doi: 10.1016/S0161-6420(02)01060-6 contributor: fullname: Scilley – start-page: CD002030 issue: 3 year: 2005 ident: 10.1016/j.ophtha.2013.10.037_bib8 article-title: Photodynamic therapy for neovascular age-related macular degeneration publication-title: Cochrane Database Syst Rev contributor: fullname: Wormald – volume: 29 start-page: 107 year: 2011 ident: 10.1016/j.ophtha.2013.10.037_bib24 article-title: Cost effectiveness of treatments for wet age-related macular degeneration publication-title: Pharmacoeconomics doi: 10.2165/11585520-000000000-00000 contributor: fullname: Mitchell – volume: 23 start-page: 279 year: 2003 ident: 10.1016/j.ophtha.2013.10.037_bib44 article-title: CME review: a cost-utility analysis of laser photocoagulation for extrafoveal choroidal neovascularization publication-title: Retina doi: 10.1097/00006982-200306000-00001 contributor: fullname: Busbee – ident: 10.1016/j.ophtha.2013.10.037_bib40 – volume: 7 year: 2003 ident: 10.1016/j.ophtha.2013.10.037_bib48 article-title: Clinical effectiveness and cost-utility of photodynamic therapy for wet age-related macular degeneration: a systematic review and economic evaluation publication-title: Health Technol Assess doi: 10.3310/hta7090 contributor: fullname: Meads – volume: 23 start-page: 2574 year: 2005 ident: 10.1016/j.ophtha.2013.10.037_bib53 article-title: Thromboembolic events in gastric cancer: high incidence in patients receiving irinotecan- and bevacizumab-based therapy [letter] publication-title: J Clin Oncol doi: 10.1200/JCO.2005.81.908 contributor: fullname: Shah – volume: 355 start-page: 1419 year: 2006 ident: 10.1016/j.ophtha.2013.10.037_bib9 article-title: MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration publication-title: N Engl J Med doi: 10.1056/NEJMoa054481 contributor: fullname: Rosenfeld – volume: 100 start-page: 912 year: 1982 ident: 10.1016/j.ophtha.2013.10.037_bib6 article-title: Argon laser photocoagulation for senile macular degeneration. Results of a randomized clinical trial publication-title: Arch Ophthalmol doi: 10.1001/archopht.1982.01030030920003 – volume: 88 start-page: 982 year: 2004 ident: 10.1016/j.ophtha.2013.10.037_bib47 article-title: Cost utility of photodynamic therapy for predominantly classic neovascular age related macular degeneration publication-title: Br J Ophthalmol doi: 10.1136/bjo.2003.039131 contributor: fullname: Hopley – ident: 10.1016/j.ophtha.2013.10.037_bib54 doi: 10.1111/j.1755-3768.2011.02240.x – volume: 115 start-page: 1039 year: 2008 ident: 10.1016/j.ophtha.2013.10.037_bib18 article-title: A value-based medicine analysis of ranibizumab for the treatment of subfoveal neovascular macular degeneration publication-title: Ophthalmology doi: 10.1016/j.ophtha.2007.08.033 contributor: fullname: Brown – ident: 10.1016/j.ophtha.2013.10.037_bib27 |
SSID | ssj0006634 |
Score | 2.4365313 |
Snippet | Purpose We sought to determine the most cost-effective treatment for patients with newly diagnosed neovascular macular degeneration: monthly or as-needed... We sought to determine the most cost-effective treatment for patients with newly diagnosed neovascular macular degeneration: monthly or as-needed bevacizumab... |
SourceID | pubmedcentral crossref pubmed elsevier |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 936 |
SubjectTerms | Aged, 80 and over Angiogenesis Inhibitors - adverse effects Angiogenesis Inhibitors - economics Angiogenesis Inhibitors - therapeutic use Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - economics Antibodies, Monoclonal, Humanized - therapeutic use Bevacizumab Cost-Benefit Analysis Drug Costs Health Care Costs Humans Markov Chains Models, Theoretical Ophthalmology Quality-Adjusted Life Years Ranibizumab Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - economics Visual Acuity - physiology Wet Macular Degeneration - drug therapy Wet Macular Degeneration - economics |
Title | Cost-Effectiveness of Bevacizumab and Ranibizumab for Newly Diagnosed Neovascular Macular Degeneration |
URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0161642013010439 https://dx.doi.org/10.1016/j.ophtha.2013.10.037 https://www.ncbi.nlm.nih.gov/pubmed/24405740 https://pubmed.ncbi.nlm.nih.gov/PMC4109727 |
Volume | 121 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db5swFLWyVJr2Mu173Zf8sLcIhMEEeMzSTVWrdNOWan1DF2OWVA1UDWnV_qD9zl1jQ5xlWte9kIQEB7jH9rmXc68Jec-8LGPCz5wsAc_hgmOXEnHuJIDuVsgg502G9-RouH_MD07Ck17vp6VaWtWZK27-mFfyP1bFfWhXlSV7B8t2jeIOfI_2xS1aGLf_ZONxtawdXX-4HbSQ-32QlyDmN6sFZDr9EMp5Zj4rUSGOa2fXONY1Gjvkm0dyrUedgH7dkz-aetSd2Qx__Xw-q2dwttCVm5rwg1lxS2vwy9K1Ygvf2qU0D6rlbAWDPXcde75aQOmMwTy3UgJFGIzK9UP-yYVar2verDg1mMKlCTqutUPqkMEX1w5bMFvtYiKZQ-ag8-NtDMU-szDHrYE1CYbWHJ3oEpRbw7-ORJy6VXMzlHAvcJV2T9eV2ay2_dss2GkTW9nbaapbSVUruCvFVu6RHT9KwrBPdkaHX78fdnM-8jZTRV5fVJuk2SgJt8_mVhK0KdC1GM_0EXloXBU60rh7THqyfELuT4wY4ykptuFHq4Ja8KMIP2rBjyL8aAM_2sGPWvCjBn7Uht8zcvzp43S875hlOxwRsrh2VFidDXOcZiEomJCqYiUEsZeDCFXv90UeobMUoSfNkT6BBxFjIALBkW1GYRE8J_2yKuVLQmXmgUziwg-SkOfIq3gcxjE6MYkEZOrFLnHa-5ie6-os6d_st0ui9manbeYxzpVyaTr1MmXp0k89pXkcMmVIpHhMZY_bRxpuqjlniti75T9faGN2Z4iMGr0k7mGbG2bufqBKvm9-U85nTel3rgQjfvTqjtf9mjxY98E3pF9frORbJNN19s4g-Rfxecyl |
link.rule.ids | 230,315,786,790,891,27955,27956 |
linkProvider | Library Specific Holdings |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cost-Effectiveness+of+Bevacizumab+and+Ranibizumab+for+Newly+Diagnosed+Neovascular+Macular+Degeneration&rft.jtitle=Ophthalmology+%28Rochester%2C+Minn.%29&rft.au=Stein%2C+Joshua+D.&rft.au=Newman-Casey%2C+Paula+Anne&rft.au=Mrinalini%2C+Tavag&rft.au=Lee%2C+Paul+P.&rft.date=2014-04-01&rft.issn=0161-6420&rft.volume=121&rft.issue=4&rft.spage=936&rft.epage=945&rft_id=info:doi/10.1016%2Fj.ophtha.2013.10.037&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_ophtha_2013_10_037 |
thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F01616420%2FS0161642013X00156%2Fcov150h.gif |