Cerebello-Thalamo-Cortical Hyperconnectivity Classifies Patients and Predicts Long-Term Treatment Outcome in First-Episode Schizophrenia

• Published in: Schizophrenia bulletin Vol. 48; no. 2; pp. 505 - 513
• Main Authors: Cao, Hengyi, Wei, Xia, Hu, Na, Zhang, Wenjing, Xiao, Yuan, Zeng, Jiaxin, Sweeney, John A, Lencer, Rebekka, Lui, Su, Gong, Qiyong
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.03.2022
• Subjects: Adolescent; Adult; Area Under Curve; Biomarkers; Cerebellum - physiology; Cerebellum - physiopathology; Cerebral Cortex - physiology; Cerebral Cortex - physiopathology; Classification; Female; Humans; Independent sample; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - statistics & numerical data; Male; Nerve Net - physiology; Regular; ROC Curve; Schizophrenia; Schizophrenia - physiopathology; Schizophrenia - therapy; Thalamus - physiology; Thalamus - physiopathology; Treatment Outcome; prognostic biomarker/schizophrenia; functional connectivity; diagnostic biomarker; cerebellum; thalamus

Abstract It has previously been shown that cerebello-thalamo-cortical (CTC) hyperconnectivity is likely a state-independent neural signature for psychosis. However, the potential clinical utility of this change has not yet been evaluated. Here, using fMRI and clinical data acquired from 214 untreate...