Analysis of cyanobacterial toxins by hydrophilic interaction liquid chromatography–mass spectrometry

• Published in: Journal of Chromatography A Vol. 1028; no. 1; pp. 155 - 164
• Main Authors: Dell’Aversano, Carmela, Eaglesham, Geoffrey K, Quilliam, Michael A
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 27.02.2004; Elsevier
• Subjects: Anatoxins; Bacteria; Bacterial Toxins - analysis; Bacteriology; Biological and medical sciences; Chromatography, Liquid - methods; Cyanobacteria - chemistry; Cyanotoxins; Cylindrospermopsin; Fundamental and applied biological sciences. Psychology; Hydrophilic interaction chromatography; Microbiology; Microcystins; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; Saxitoxins; Spectrometry, Mass, Electrospray Ionization - methods; Toxins; Anatoxins; Hydrophilic interaction chromatography; Cyanotoxins; Cylindrospermopsin; Bacteria; Toxins; Saxitoxins; Microcystins; Chemical analysis; Angular nitrogen heterocycle; Nitrogen heterocycle; Coupled method; Cyclic peptides; Toxoid; Liquid chromatography; Tricyclic compound; Electrospray; Hydrophilic Interaction Liquid Chromatography; Toxin; Anabaena; Cyanobacteria; Bicyclic compound; Mass spectrometry

The combination of hydrophilic interaction liquid chromatography with electrospray mass spectrometry (HILIC–MS) has been investigated as a tool for the analysis of assorted toxins produced by cyanobacteria. Toxins examined included saxitoxin and its various analogues ( 1– 18), anatoxin-a (ATX-a, 19)...