Glucose controls manganese homeostasis through transcription factors regulating known and newly-identified manganese transporter genes in Bacillus subtilis

• Published in: The Journal of biological chemistry Vol. 299; no. 8; p. 105069
• Main Authors: Ogura, Mitsuo, Matsutani, Minenosuke, Asai, Kei, Suzuki, Michio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2023; American Society for Biochemistry and Molecular Biology
• Subjects: Glucose induction; Manganese homeostasis; Manganese transporter genes; Metabolic homeostasis; RNA-Seq; Metabolic homeostasis; GI; Glucose induction; DTT; DEG; poly[dI-dC]; Tris; Manganese homeostasis; NRAMP; SDS-PAGE; Manganese transporter genes; ONPG; RNA-Seq; FDR; MC medium; EMSA; IPTG; SM; LB medium; ICP-MS; FC; CPRG; β-Gal; manganese homeostasis; metabolic homeostasis; glucose induction; manganese transporter genes

Mn2+ is an essential nutrient whose concentration is tightly controlled in bacteria. In B. subtilis, the Mn2+-activated transcription factor MntR controls Mn2+ transporter genes. However, factors regulating intracellular Mn2+ concentration are incompletely understood. Here, we found that glucose add...