A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound

• Published in: Bioactive materials Vol. 20; pp. 610 - 626
• Main Authors: Liu, Zhengwei, Tang, Wanze, Liu, Jiayi, Han, Yingying, Yan, Qinnan, Dong, Yuechao, Liu, Xiaomei, Yang, Dazhi, Ma, Guixing, Cao, Huiling
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2023; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Autophagy; Reactive oxygen species (ROS); Skin wound; Thermosensitive hydrogel; ZnMet-PF127; ZnMet-PF127; Autophagy; Thermosensitive hydrogel; Reactive oxygen species (ROS); Skin wound

A novel sprayable adhesive is established (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and a coordination complex of zinc and metformin (ZnMet). Here we demonstrate that ZnMet-PF127 potently promotes the healing of traumatic skin defect and burn skin injury b...