Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

• Published in: Nature (London) Vol. 602; no. 7896; pp. 300 - 306
• Main Authors: Saito, Akatsuki, Irie, Takashi, Suzuki, Rigel, Maemura, Tadashi, Nasser, Hesham, Uriu, Keiya, Kosugi, Yusuke, Shirakawa, Kotaro, Sadamasu, Kenji, Kimura, Izumi, Ito, Jumpei, Wu, Jiaqi, Iwatsuki-Horimoto, Kiyoko, Ito, Mutsumi, Yamayoshi, Seiya, Loeber, Samantha, Tsuda, Masumi, Wang, Lei, Ozono, Seiya, Butlertanaka, Erika P., Tanaka, Yuri L., Shimizu, Ryo, Shimizu, Kenta, Yoshimatsu, Kumiko, Kawabata, Ryoko, Sakaguchi, Takemasa, Tokunaga, Kenzo, Yoshida, Isao, Asakura, Hiroyuki, Nagashima, Mami, Kazuma, Yasuhiro, Nomura, Ryosuke, Horisawa, Yoshihito, Yoshimura, Kazuhisa, Takaori-Kondo, Akifumi, Imai, Masaki, Tanaka, Shinya, Nakagawa, So, Ikeda, Terumasa, Fukuhara, Takasuke, Kawaoka, Yoshihiro, Sato, Kei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.02.2022; Nature Publishing Group
• Subjects: 13; 631/326/596/2555; 631/326/596/4130; 64; Amino Acid Substitution; Animals; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Coronaviruses; COVID-19; COVID-19 - epidemiology; COVID-19 - virology; Cricetinae; Genomes; Giant Cells - metabolism; Giant Cells - virology; Hamsters; Humanities and Social Sciences; Infections; Lungs; Male; Membrane Fusion; Mesocricetus; multidisciplinary; Mutation; Pandemics; Pathogenicity; Pathogens; Phenotypes; Phylogeny; Proteins; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; SARS-CoV-2 - metabolism; SARS-CoV-2 - pathogenicity; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Spike protein; Viral diseases; Virulence - genetics; Virus Replication; Viruses; India

During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, at the time of writing, four variants of concern are considered to be potentially hazardous to human socie...