Antcin-B, a phytosterol-like compound from Taiwanofungus camphoratus inhibits SARS-CoV-2 3-chymotrypsin-like protease (3CLPro) activity in silico and in vitro

• Published in: Scientific reports Vol. 13; no. 1; pp. 17106 - 16
• Main Authors: Dakpa, Gyaltsen, Kumar, K. J. Senthil, Nelen, Jochem, Pérez-Sánchez, Horacio, Wang, Sheng-Yang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154; 631/45/607; 631/92; 692/699/255/1901; Affinity; Chymotrypsin; Coronaviruses; COVID-19; Cytotoxicity; Humanities and Social Sciences; Molecular dynamics; Molecular modelling; mRNA; multidisciplinary; Replication; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Taiwanofungus camphoratus; Vaccines

Despite the remarkable development of highly effective vaccines, including mRNA-based vaccines, within a limited timeframe, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not been entirely eradicated. Thus, it is crucial to identify new...