Network pharmacology-based investigation and experimental validation of the mechanism of metformin in the treatment of acute myeloid leukemia - Liu, Shaoyu; Xu, Mingming; Yang, Zhuofan; Li, Yangzi; Wu, Depei; Tang, Xiaowen (European journal of medical research, 2024)
Keywords: AML; Apoptosis; Apoptosis - drug effects; Cancer; Care and treatment; Cell Proliferation - drug effects; Diabetes therapy; Drug therapy; Gene Regulatory Networks - drug effects; Genes; Genomes; Genomics; HIF1A; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - metabolism; Leukemia, Myeloid, Acute - pathology; Metformin; Metformin - pharmacology; Metformin - therapeutic use; Network pharmacology; Network Pharmacology - methods; Pharmacology; Protein Interaction Maps - drug effects; Protein-protein interactions; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction - drug effects; Type 2 diabetes; AML; Network pharmacology; Metformin; HIF1A; Apoptosis