Photodegradation illuminates the role of polyanions in prion infectivity

• Published in: Prion Vol. 5; no. 2; pp. 49 - 51
• Main Authors: Piro, Justin R., Supattapone, Surachai
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.04.2011; Landes Bioscience
• Subjects: Animals; Binding; Biology; Bioscience; Calcium; Cancer; Cell; Cycle; Humans; Landes; Organogenesis; Photolysis; Polymers - metabolism; Prions - metabolism; Proteins; View

Understanding the mechanism by which prion infectivity is encoded by the misfolded protein PrP Sc remains a high priority within the prion field. Work from several groups has indicated cellular cofactors may be necessary to form infectious prions in vitro. The identity of endogenous prion conversion...