Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

• Published in: Bioactive materials Vol. 8; pp. 368 - 380
• Main Authors: Zhang, Mei, Zhang, Xiaolin, Tian, Taoran, Zhang, Qi, Wen, Yuting, Zhu, Junyao, Xiao, Dexuan, Cui, Weitong, Lin, Yunfeng
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2022; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Gouty arthritis; Macrophage; NF-κB signaling pathway; Oxidative stress; Tetrahedral framework DNA nanoparticle; Oxidative stress; Tetrahedral framework DNA nanoparticle; NF-κB signaling pathway; Gouty arthritis; Macrophage

Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural ant...