Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis
Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural ant...
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| Published in | Bioactive materials Vol. 8; pp. 368 - 380 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.02.2022
KeAi Publishing KeAi Communications Co., Ltd |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural anti-inflammatory drug, has demonstrated good safety and efficacy. However, the rapid degradation, poor aqueous solubility, and low bioavailability of Cur limit its therapeutic effect. To strengthen the effectiveness and bioavailability of Cur. Cur loaded tetrahedral framework nucleic acids (Cur-TFNAs) were synthesized to deliver Cur. Compared with free Cur, Cur-TFNAs exhibit a preferable drug stability, good biocompatibility (CCK-8 assay), ease of uptake (immunofluorescence), and higher tissue utilization (in vivo biodistribution). Most importantly, Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression. Therefore, we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases.
Schematic illustration of treating acute gouty arthritis with Cur loaded TFNAs. Cur-TFNAs were absorbed by inflammatory RAW264.7 cells and inhibited the activation of NF-κB, which decreased the levels of ROS, NO and inflammatory factors (IL-6, IL-1β and TNF-α), thus affecting the progression of acute gouty arthritis. [Display omitted]
•The drug curcumin system based on DNA nanostructures (Cur-TFNAs) were developed to obtain a novel nanomaterial with high water solubility, large encapsulation efficiency, sustained drug release and excellent drug stability.•Based on cellular uptake and in vivo drug imaging, Cur-TFNAs improve the retention of Cur in cells and tissues.•Cur-TFNAs prevent acute gouty arthritis through mediating anti-inflammatory and antioxidant responses of macrophage. |
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| AbstractList | Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural anti-inflammatory drug, has demonstrated good safety and efficacy. However, the rapid degradation, poor aqueous solubility, and low bioavailability of Cur limit its therapeutic effect. To strengthen the effectiveness and bioavailability of Cur. Cur loaded tetrahedral framework nucleic acids (Cur-TFNAs) were synthesized to deliver Cur. Compared with free Cur, Cur-TFNAs exhibit a preferable drug stability, good biocompatibility (CCK-8 assay), ease of uptake (immunofluorescence), and higher tissue utilization (in vivo biodistribution). Most importantly, Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression. Therefore, we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases.
Schematic illustration of treating acute gouty arthritis with Cur loaded TFNAs. Cur-TFNAs were absorbed by inflammatory RAW264.7 cells and inhibited the activation of NF-κB, which decreased the levels of ROS, NO and inflammatory factors (IL-6, IL-1β and TNF-α), thus affecting the progression of acute gouty arthritis.
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The drug curcumin system based on DNA nanostructures (Cur-TFNAs) were developed to obtain a novel nanomaterial with high water solubility, large encapsulation efficiency, sustained drug release and excellent drug stability.
•
Based on cellular uptake and in vivo drug imaging, Cur-TFNAs improve the retention of Cur in cells and tissues.
•
Cur-TFNAs prevent acute gouty arthritis through mediating anti-inflammatory and antioxidant responses of macrophage. Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural anti-inflammatory drug, has demonstrated good safety and efficacy. However, the rapid degradation, poor aqueous solubility, and low bioavailability of Cur limit its therapeutic effect. To strengthen the effectiveness and bioavailability of Cur. Cur loaded tetrahedral framework nucleic acids (Cur-TFNAs) were synthesized to deliver Cur. Compared with free Cur, Cur-TFNAs exhibit a preferable drug stability, good biocompatibility (CCK-8 assay), ease of uptake (immunofluorescence), and higher tissue utilization (in vivo biodistribution). Most importantly, Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression. Therefore, we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases.Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural anti-inflammatory drug, has demonstrated good safety and efficacy. However, the rapid degradation, poor aqueous solubility, and low bioavailability of Cur limit its therapeutic effect. To strengthen the effectiveness and bioavailability of Cur. Cur loaded tetrahedral framework nucleic acids (Cur-TFNAs) were synthesized to deliver Cur. Compared with free Cur, Cur-TFNAs exhibit a preferable drug stability, good biocompatibility (CCK-8 assay), ease of uptake (immunofluorescence), and higher tissue utilization (in vivo biodistribution). Most importantly, Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression. Therefore, we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases. Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural anti-inflammatory drug, has demonstrated good safety and efficacy. However, the rapid degradation, poor aqueous solubility, and low bioavailability of Cur limit its therapeutic effect. To strengthen the effectiveness and bioavailability of Cur. Cur loaded tetrahedral framework nucleic acids (Cur-TFNAs) were synthesized to deliver Cur. Compared with free Cur, Cur-TFNAs exhibit a preferable drug stability, good biocompatibility (CCK-8 assay), ease of uptake (immunofluorescence), and higher tissue utilization (in vivo biodistribution). Most importantly, Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression. Therefore, we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases. Schematic illustration of treating acute gouty arthritis with Cur loaded TFNAs. Cur-TFNAs were absorbed by inflammatory RAW264.7 cells and inhibited the activation of NF-κB, which decreased the levels of ROS, NO and inflammatory factors (IL-6, IL-1β and TNF-α), thus affecting the progression of acute gouty arthritis. [Display omitted] •The drug curcumin system based on DNA nanostructures (Cur-TFNAs) were developed to obtain a novel nanomaterial with high water solubility, large encapsulation efficiency, sustained drug release and excellent drug stability.•Based on cellular uptake and in vivo drug imaging, Cur-TFNAs improve the retention of Cur in cells and tissues.•Cur-TFNAs prevent acute gouty arthritis through mediating anti-inflammatory and antioxidant responses of macrophage. Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural anti-inflammatory drug, has demonstrated good safety and efficacy. However, the rapid degradation, poor aqueous solubility, and low bioavailability of Cur limit its therapeutic effect. To strengthen the effectiveness and bioavailability of Cur. Cur loaded tetrahedral framework nucleic acids (Cur-TFNAs) were synthesized to deliver Cur. Compared with free Cur, Cur-TFNAs exhibit a preferable drug stability, good biocompatibility (CCK-8 assay), ease of uptake (immunofluorescence), and higher tissue utilization (in vivo biodistribution). Most importantly, Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression. Therefore, we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases. |
| Author | Zhang, Qi Tian, Taoran Xiao, Dexuan Lin, Yunfeng Wen, Yuting Cui, Weitong Zhu, Junyao Zhang, Xiaolin Zhang, Mei |
| Author_xml | – sequence: 1 givenname: Mei surname: Zhang fullname: Zhang, Mei organization: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China – sequence: 2 givenname: Xiaolin surname: Zhang fullname: Zhang, Xiaolin organization: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China – sequence: 3 givenname: Taoran surname: Tian fullname: Tian, Taoran organization: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China – sequence: 4 givenname: Qi surname: Zhang fullname: Zhang, Qi organization: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China – sequence: 5 givenname: Yuting surname: Wen fullname: Wen, Yuting organization: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China – sequence: 6 givenname: Junyao surname: Zhu fullname: Zhu, Junyao organization: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China – sequence: 7 givenname: Dexuan surname: Xiao fullname: Xiao, Dexuan organization: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China – sequence: 8 givenname: Weitong surname: Cui fullname: Cui, Weitong organization: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China – sequence: 9 givenname: Yunfeng orcidid: 0000-0003-1224-6561 surname: Lin fullname: Lin, Yunfeng email: yunfenglin@scu.edu.cn organization: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China |
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| Cites_doi | 10.1021/acs.accounts.5b00127 10.3390/molecules16064567 10.1016/j.jconrel.2006.04.014 10.1002/art.40807 10.1016/j.nano.2019.102061 10.1039/C7NR09692E 10.1021/acs.nanolett.0c00529 10.5604/17322693.991446 10.1016/j.biomaterials.2007.12.037 10.1186/1742-2094-8-125 10.1021/acs.nanolett.8b02166 10.1016/j.bioactmat.2020.12.027 10.1016/j.autrev.2009.02.026 10.1038/nature04516 10.1039/c1np00051a 10.1002/smll.201800703 10.1016/j.brainres.2009.05.009 10.1097/RHU.0b013e31827d8790 10.2217/nnm.09.28 10.1016/S0140-6736(16)00346-9 10.1016/S0168-3659(02)00127-X 10.1016/j.biomaterials.2011.10.070 10.1021/bm800479e 10.1038/nprot.2015.078 10.1016/j.biomaterials.2010.04.062 10.1016/j.nano.2014.09.004 10.1126/stke.11pe1 10.1016/j.lfs.2003.10.042 10.1021/acs.chemrev.7b00663 10.1038/ni1001-907 10.1016/j.cell.2007.08.024 10.1021/acsami.9b10645 10.1038/cddis.2017.470 10.1002/adma.201300875 10.1038/nrrheum.2014.32 10.1158/1078-0432.CCR-04-2517 10.1021/nn4058787 10.1158/1078-0432.CCR-07-5177 10.1021/nn2005574 10.2217/nnm.10.9 10.1016/j.mattod.2018.08.002 10.2165/00002018-199411040-00004 10.1046/j.1365-2796.2003.01146.x 10.1016/j.lfs.2005.12.007 10.1021/mp700113r 10.1038/s41413-019-0077-4 10.1096/fasebj.6.12.1381691 10.1038/s41572-019-0115-y 10.1002/art.1780340716 10.1038/s41467-018-04947-6 10.1038/s41596-020-0355-z 10.1021/nn405077y 10.1146/annurev-med-040210-162544 10.1016/j.biomaterials.2015.02.116 10.1136/annrheumdis-2011-200298 10.1021/acsami.9b13829 10.1021/acsami.8b22444 10.1101/gad.9.22.2736 10.1002/art.24185 10.1016/j.it.2015.01.003 |
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| References | Conaghan, Day (bib8) 1994; 11 De Jong, Hagens, Krystek, Burger, Sips, Geertsma (bib40) 2008; 29 Boumans, Houbiers, Verschueren, Ishikura, Westhovens, Brouwer, Rojkovich, Kelly, den Adel, Isaacs, Jacobs, Gomez-Reino, Holtkamp, Hastings, Gerlag, Tak (bib63) 2012; 71 Li, Fan, Pei, Shi, Huang (bib42) 2013; 25 Zhang, Ma, Zhu, Shi, Li, Mao, Zhao, Zhan, Shi, Li, Wang, Fan, Lin (bib26) 2018; 18 Terkeltaub, Zachariae, Santoro, Martin, Peveri, Matsushima (bib6) 1991; 34 Bogdan (bib55) 2001; 2 Sahoo, Panyam, Prabha, Labhasetwar (bib47) 2002; 82 Sun, Ren, Xiong, Chen, Zhao, Wang, Zhou, Han, Chen, Li, Kang, Zhu (bib14) 2017; 8 Fu, You, Ma, Li, Ju, Guo, Shi, Zhang, Zhou, Lin (bib29) 2019; 11 Martinon, Pétrilli, Mayor, Tardivel, Tschopp (bib4) 2006; 440 Zhang, Tian, Zhou, Li, Ma, Zhang, Liu, Shi, Li, Xie, Ge, Liu, Zhang, Lin, Cai, Lin (bib25) 2020; 15 Wang, Wang, Zhu, Liu, Fei, Wang (bib20) 2015; 53 Maheshwari, Singh, Gaddipati, Srimal (bib9) 2006; 78 Basnet, Skalko-Basnet (bib10) 2011; 16 Gupta, Prasad, Kim, Patchva, Webb, Priyadarsini, Aggarwal (bib44) 2011; 28 Sun, Liu, Zhang, Shi, Zhang, Zhao, Tian, Li, Lin (bib33) 2021; 6 Canty, Boyle, Farr, Morgan, Verrier, Pohlman (bib58) 1999; 100 Hainer, Matheson, Wilkes (bib62) 2014; 90 Sirong, Yang, Taoran, Songhang, Shiyu, Yuxin, Xiaoru, Tao, Yunfeng, Xiaoxiao (bib35) 2020; 8 Dalbeth, Merriman, Stamp, Gout (bib1) 2016; 388 Mohanty, Sahoo (bib36) 2010; 31 Tiwari, Agarwal, Seth, Yadav, Nair, Bhatnagar, Karmakar, Kumari, Chauhan, Patel (bib18) 2014; 8 Chen, He, Su, Li, Huang, Wang, Zhang, Tai, Fan (bib39) 2012; 33 Krausz, Adler, Cabral, Navati, Doerner, Charafeddine, Chandra, Liang, Gunther, Clendaniel (bib13) 2015; 11 Shi, Fu, Lin, Tian, Li, Shao, Zhang, Zhang, Tang, Zhou (bib32) 2019; 21 Stubelius, Sheng, Lee, Olejniczak, Guma, Almutairi (bib59) 2018; 14 Szwed, Miłowska (bib17) 2012; 66 Wang, Veena, Stevenson, Tang, Ho, Suh, Duarte, Faull, Mehta, Srivatsan (bib53) 2008; 14 Banerjee, Chakravarty (bib21) 2015; 48 Ko, Liu, Chen, Mao (bib41) 2008; 9 Lv, Hu, Zhu, Zhang, Mei, Liu, Qiu, Wu, Tan (bib43) 2015; 10 Tian, Xiao, Zhang, Li, Shi, Zhong, Gong, Liu, Li, Lin (bib27) 2020 Cronstein, Sunkureddi (bib5) 2013; 19 Karlstetter, Lippe, Walczak, Moehle, Aslanidis, Mirza, Langmann (bib15) 2011; 8 Creus, De Paepe, De Bleecker (bib51) 2009; 8 Yang, Zhang, Fan, Liu (bib12) 2009; 1282 Dalbeth, Choi, Joosten, Khanna, Matsuo, Perez-Ruiz, Stamp, Gout (bib7) 2019; 5 Lv, Zhang, Wang, Cui, Yan (bib38) 2006; 114 Zhang, Zhu, Qin, Zhou, Zhang, Gao, Zhang, Xiao, Cui, Cai (bib37) 2019; 11 Chen-Xu, Yokose, Rai, Pillinger, Choi (bib2) 2019; 71 Martin, Walton, Harper (bib3) 2009; 60 Walsh, Yin, Erben, Wood, Turberfield (bib28) 2011; 5 Meng, Ma, Lin, Shi, Li, Lin (bib31) 2019; 11 Li, Tian, Zhang, Cai, Lin (bib49) 2019; 24 Nathan (bib56) 1992; 6 Rees, Hui, Doherty (bib61) 2014; 10 Pu, Chiang, Maiti, Liao, Ho, Shim, Chuang, Xia, Sung (bib19) 2014; 8 Gambaro, Perazella (bib60) 2003; 253 Mohanty, Acharya, Mohanty, Dilnawaz, Sahoo (bib45) 2010; 5 Beg, Sha, Bronson, Baltimore (bib52) 1995; 9 Allen, Mumbengegwi, Charrois (bib22) 2005; 11 He, Jiang, Chen, Ye, Wang, Wang, Liu, Liang, Deng, Jiang, Zhou (bib48) 2018; 9 Bogdan (bib57) 2015; 36 Natoli, Chiocca (bib50) 2008; 1 Xie, Shao, Ma, Zhao, Shi, Li, Lin (bib34) 2018; 10 Liu, Sun, Li, Liu, Qin, Chen, Lin (bib24) 2020; 20 Hu, Li, Wang, Gu, Fan (bib30) 2018; 119 Aktan (bib54) 2004; 75 Wang, Langer, Farokhzad (bib23) 2012; 63 Anand, Kunnumakkara, Newman, Aggarwal (bib16) 2007; 4 Singh (bib11) 2007; 130 Misra, Acharya, Dilnawaz, Sahoo (bib46) 2009; 4 Hu (10.1016/j.bioactmat.2021.06.003_bib30) 2018; 119 Wang (10.1016/j.bioactmat.2021.06.003_bib23) 2012; 63 Chen (10.1016/j.bioactmat.2021.06.003_bib39) 2012; 33 Bogdan (10.1016/j.bioactmat.2021.06.003_bib57) 2015; 36 Natoli (10.1016/j.bioactmat.2021.06.003_bib50) 2008; 1 Misra (10.1016/j.bioactmat.2021.06.003_bib46) 2009; 4 Krausz (10.1016/j.bioactmat.2021.06.003_bib13) 2015; 11 Lv (10.1016/j.bioactmat.2021.06.003_bib43) 2015; 10 Singh (10.1016/j.bioactmat.2021.06.003_bib11) 2007; 130 Karlstetter (10.1016/j.bioactmat.2021.06.003_bib15) 2011; 8 Sun (10.1016/j.bioactmat.2021.06.003_bib14) 2017; 8 Sun (10.1016/j.bioactmat.2021.06.003_bib33) 2021; 6 Gupta (10.1016/j.bioactmat.2021.06.003_bib44) 2011; 28 Sahoo (10.1016/j.bioactmat.2021.06.003_bib47) 2002; 82 Shi (10.1016/j.bioactmat.2021.06.003_bib32) 2019; 21 Creus (10.1016/j.bioactmat.2021.06.003_bib51) 2009; 8 Conaghan (10.1016/j.bioactmat.2021.06.003_bib8) 1994; 11 Nathan (10.1016/j.bioactmat.2021.06.003_bib56) 1992; 6 Zhang (10.1016/j.bioactmat.2021.06.003_bib26) 2018; 18 Tian (10.1016/j.bioactmat.2021.06.003_bib27) 2020 Tiwari (10.1016/j.bioactmat.2021.06.003_bib18) 2014; 8 Chen-Xu (10.1016/j.bioactmat.2021.06.003_bib2) 2019; 71 Pu (10.1016/j.bioactmat.2021.06.003_bib19) 2014; 8 Wang (10.1016/j.bioactmat.2021.06.003_bib20) 2015; 53 Canty (10.1016/j.bioactmat.2021.06.003_bib58) 1999; 100 Meng (10.1016/j.bioactmat.2021.06.003_bib31) 2019; 11 Anand (10.1016/j.bioactmat.2021.06.003_bib16) 2007; 4 Li (10.1016/j.bioactmat.2021.06.003_bib42) 2013; 25 He (10.1016/j.bioactmat.2021.06.003_bib48) 2018; 9 Hainer (10.1016/j.bioactmat.2021.06.003_bib62) 2014; 90 Xie (10.1016/j.bioactmat.2021.06.003_bib34) 2018; 10 De Jong (10.1016/j.bioactmat.2021.06.003_bib40) 2008; 29 Wang (10.1016/j.bioactmat.2021.06.003_bib53) 2008; 14 Beg (10.1016/j.bioactmat.2021.06.003_bib52) 1995; 9 Dalbeth (10.1016/j.bioactmat.2021.06.003_bib7) 2019; 5 Ko (10.1016/j.bioactmat.2021.06.003_bib41) 2008; 9 Yang (10.1016/j.bioactmat.2021.06.003_bib12) 2009; 1282 Martin (10.1016/j.bioactmat.2021.06.003_bib3) 2009; 60 Mohanty (10.1016/j.bioactmat.2021.06.003_bib45) 2010; 5 Walsh (10.1016/j.bioactmat.2021.06.003_bib28) 2011; 5 Li (10.1016/j.bioactmat.2021.06.003_bib49) 2019; 24 Aktan (10.1016/j.bioactmat.2021.06.003_bib54) 2004; 75 Allen (10.1016/j.bioactmat.2021.06.003_bib22) 2005; 11 Mohanty (10.1016/j.bioactmat.2021.06.003_bib36) 2010; 31 Rees (10.1016/j.bioactmat.2021.06.003_bib61) 2014; 10 Stubelius (10.1016/j.bioactmat.2021.06.003_bib59) 2018; 14 Dalbeth (10.1016/j.bioactmat.2021.06.003_bib1) 2016; 388 Martinon (10.1016/j.bioactmat.2021.06.003_bib4) 2006; 440 Basnet (10.1016/j.bioactmat.2021.06.003_bib10) 2011; 16 Maheshwari (10.1016/j.bioactmat.2021.06.003_bib9) 2006; 78 Liu (10.1016/j.bioactmat.2021.06.003_bib24) 2020; 20 Bogdan (10.1016/j.bioactmat.2021.06.003_bib55) 2001; 2 Terkeltaub (10.1016/j.bioactmat.2021.06.003_bib6) 1991; 34 Sirong (10.1016/j.bioactmat.2021.06.003_bib35) 2020; 8 Zhang (10.1016/j.bioactmat.2021.06.003_bib37) 2019; 11 Zhang (10.1016/j.bioactmat.2021.06.003_bib25) 2020; 15 Gambaro (10.1016/j.bioactmat.2021.06.003_bib60) 2003; 253 Boumans (10.1016/j.bioactmat.2021.06.003_bib63) 2012; 71 Lv (10.1016/j.bioactmat.2021.06.003_bib38) 2006; 114 Cronstein (10.1016/j.bioactmat.2021.06.003_bib5) 2013; 19 Szwed (10.1016/j.bioactmat.2021.06.003_bib17) 2012; 66 Banerjee (10.1016/j.bioactmat.2021.06.003_bib21) 2015; 48 Fu (10.1016/j.bioactmat.2021.06.003_bib29) 2019; 11 |
| References_xml | – volume: 130 start-page: 765 year: 2007 end-page: 768 ident: bib11 article-title: From exotic spice to modern drug? publication-title: Cell – volume: 8 start-page: 1213 year: 2014 end-page: 1221 ident: bib19 article-title: Nanoparticles with dual responses to oxidative stress and reduced ph for drug release and anti-inflammatory applications publication-title: ACS Nano – volume: 5 start-page: 433 year: 2010 end-page: 449 ident: bib45 article-title: Curcumin-encapsulated mepeg/pcl diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy publication-title: Nanomed – volume: 9 start-page: 2550 year: 2018 ident: bib48 article-title: Oridonin is a covalent nlrp3 inhibitor with strong anti-inflammasome activity publication-title: Nat. Commun. – volume: 20 start-page: 3602 year: 2020 end-page: 3610 ident: bib24 article-title: Tetrahedral framework nucleic acids deliver antimicrobial peptides with improved effects and less susceptibility to bacterial degradation publication-title: Nano Lett. – volume: 24 start-page: 57 year: 2019 end-page: 68 ident: bib49 article-title: Advances in biological applications of self-assembled DNA tetrahedral nanostructures publication-title: Mater. Today – volume: 11 start-page: 39525 year: 2019 end-page: 39533 ident: bib29 article-title: Enhanced efficacy of temozolomide loaded by a tetrahedral framework DNA nanoparticle in the therapy for glioblastoma publication-title: ACS Appl. Mater. Interfaces – volume: 78 start-page: 2081 year: 2006 end-page: 2087 ident: bib9 article-title: Multiple biological activities of curcumin: a short review publication-title: Life Sci. – volume: 28 start-page: 1937 year: 2011 end-page: 1955 ident: bib44 article-title: Multitargeting by curcumin as revealed by molecular interaction studies publication-title: Nat. Prod. Rep. – start-page: 2007342 year: 2020 ident: bib27 article-title: A framework nucleic acid based robotic nanobee for active targeting therapy publication-title: Adv. Funct. Mater. n/a – volume: 63 start-page: 185 year: 2012 end-page: 198 ident: bib23 article-title: Nanoparticle delivery of cancer drugs publication-title: Annu. Rev. Med. – volume: 25 start-page: 4386 year: 2013 end-page: 4396 ident: bib42 article-title: Smart drug delivery nanocarriers with self-assembled DNA nanostructures publication-title: Adv. Mater. – volume: 71 start-page: 180 year: 2012 end-page: 185 ident: bib63 article-title: Safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the monoclonal antibody ask8007 blocking osteopontin in patients with rheumatoid arthritis: a randomised, placebo controlled, proof-of-concept study publication-title: Ann. Rheum. Dis. – volume: 29 start-page: 1912 year: 2008 end-page: 1919 ident: bib40 article-title: Particle size-dependent organ distribution of gold nanoparticles after intravenous administration publication-title: Biomaterials – volume: 11 start-page: 3567 year: 2005 end-page: 3573 ident: bib22 article-title: Anti-cd19-targeted liposomal doxorubicin improves the therapeutic efficacy in murine b-cell lymphoma and ameliorates the toxicity of liposomes with varying drug release rates publication-title: Clin. Canc. Res. – volume: 15 start-page: 2728 year: 2020 end-page: 2757 ident: bib25 article-title: Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment publication-title: Nat. Protoc. – volume: 21 start-page: 102061 year: 2019 ident: bib32 article-title: Targeted and effective glioblastoma therapy via aptamer-modified tetrahedral framework nucleic acid-paclitaxel nanoconjugates that can pass the blood brain barrier publication-title: Nanomedicine – volume: 8 start-page: 627 year: 2009 end-page: 631 ident: bib51 article-title: Idiopathic inflammatory myopathies and the classical nf-κb complex: current insights and implications for therapy publication-title: Autoimmun. Rev. – volume: 14 year: 2018 ident: bib59 article-title: Disease-triggered drug release effectively prevents acute inflammatory flare-ups, achieving reduced dosing publication-title: Small – volume: 100 year: 1999 ident: bib58 article-title: Oxidative stress induces nf-kappab nuclear translocation without degradation of ikappabalpha publication-title: Circulation – volume: 11 start-page: 6850 year: 2019 end-page: 6857 ident: bib31 article-title: Tetrahedral DNA nanostructure-delivered dnazyme for gene silencing to suppress cell growth publication-title: ACS Appl. Mater. Interfaces – volume: 4 start-page: 519 year: 2009 end-page: 530 ident: bib46 article-title: Sustained antibacterial activity of doxycycline-loaded poly(d,l-lactide-co-glycolide) and poly(epsilon-caprolactone) nanoparticles publication-title: Nanomedicine – volume: 9 start-page: 2736 year: 1995 end-page: 2746 ident: bib52 article-title: Constitutive nf-kappa b activation, enhanced granulopoiesis, and neonatal lethality in i kappa b alpha-deficient mice publication-title: Genes Dev. – volume: 90 start-page: 831 year: 2014 end-page: 836 ident: bib62 article-title: Diagnosis, treatment, and prevention of gout publication-title: Am. Fam. Physician – volume: 31 start-page: 6597 year: 2010 end-page: 6611 ident: bib36 article-title: The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation publication-title: Biomaterials – volume: 48 start-page: 2075 year: 2015 end-page: 2083 ident: bib21 article-title: Metal complexes of curcumin for cellular imaging, targeting, and photoinduced anticancer activity publication-title: Acc. Chem. Res. – volume: 10 start-page: 5457 year: 2018 end-page: 5465 ident: bib34 article-title: Overcoming drug-resistant lung cancer by paclitaxel loaded tetrahedral DNA nanostructures publication-title: Nanoscale – volume: 8 start-page: 76 year: 2014 end-page: 103 ident: bib18 article-title: Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in alzheimer's disease model via canonical wnt/β-catenin pathway publication-title: ACS Nano – volume: 82 start-page: 105 year: 2002 end-page: 114 ident: bib47 article-title: Residual polyvinyl alcohol associated with poly (d,l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake publication-title: J. Contr. Release – volume: 16 start-page: 4567 year: 2011 end-page: 4598 ident: bib10 article-title: Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment publication-title: Molecules – volume: 11 start-page: 195 year: 2015 end-page: 206 ident: bib13 article-title: Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent publication-title: Nanomedicine – volume: 1282 start-page: 133 year: 2009 end-page: 141 ident: bib12 article-title: Curcumin upregulates transcription factor nrf2, ho-1 expression and protects rat brains against focal ischemia publication-title: Brain Res. – volume: 19 start-page: 19 year: 2013 end-page: 29 ident: bib5 article-title: Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis publication-title: J. Clin. Rheumatol. – volume: 253 start-page: 643 year: 2003 end-page: 652 ident: bib60 article-title: Adverse renal effects of anti-inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors publication-title: J. Intern. Med. – volume: 71 start-page: 991 year: 2019 end-page: 999 ident: bib2 article-title: Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: the national health and nutrition examination survey, 2007-2016 publication-title: Arthritis Rheum. – volume: 36 start-page: 161 year: 2015 end-page: 178 ident: bib57 article-title: Nitric oxide synthase in innate and adaptive immunity: an update publication-title: Trends Immunol. – volume: 5 start-page: 69 year: 2019 ident: bib7 publication-title: Nat Rev Dis Primers – volume: 9 start-page: 3039 year: 2008 end-page: 3043 ident: bib41 article-title: DNA nanotubes as combinatorial vehicles for cellular delivery publication-title: Biomacromolecules – volume: 5 start-page: 5427 year: 2011 end-page: 5432 ident: bib28 article-title: DNA cage delivery to mammalian cells publication-title: ACS Nano – volume: 440 start-page: 237 year: 2006 end-page: 241 ident: bib4 article-title: Gout-associated uric acid crystals activate the nalp3 inflammasome publication-title: Nature – volume: 14 start-page: 6228 year: 2008 end-page: 6236 ident: bib53 article-title: Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor κb by an akt-independent pathway publication-title: Clin. Canc. Res. – volume: 8 year: 2017 ident: bib14 article-title: Nlrp3 inflammasome activation contributes to vsmc phenotypic transformation and proliferation in hypertension publication-title: Cell Death Dis. – volume: 119 start-page: 6459 year: 2018 end-page: 6506 ident: bib30 article-title: DNA nanotechnology-enabled drug delivery systems publication-title: Chem. Rev. – volume: 8 start-page: 6 year: 2020 ident: bib35 article-title: Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis publication-title: Bone Res – volume: 6 start-page: 3051 year: 1992 end-page: 3064 ident: bib56 article-title: Nitric oxide as a secretory product of mammalian cells publication-title: Faseb. J. – volume: 60 start-page: 281 year: 2009 end-page: 289 ident: bib3 article-title: Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal–induced murine peritoneal model of acute gout publication-title: Arthritis Rheum. – volume: 18 start-page: 5652 year: 2018 end-page: 5659 ident: bib26 article-title: Inhibiting methicillin-resistant staphylococcus aureus by tetrahedral DNA nanostructure-enabled antisense peptide nucleic acid delivery publication-title: Nano Lett. – volume: 10 start-page: 1508 year: 2015 end-page: 1524 ident: bib43 article-title: Preparation and biomedical applications of programmable and multifunctional DNA nanoflowers publication-title: Nat. Protoc. – volume: 2 start-page: 907 year: 2001 end-page: 916 ident: bib55 article-title: Nitric oxide and the immune response publication-title: Nat. Immunol. – volume: 10 start-page: 271 year: 2014 end-page: 283 ident: bib61 article-title: Optimizing current treatment of gout publication-title: Nat. Rev. Rheumatol. – volume: 11 start-page: 252 year: 1994 end-page: 258 ident: bib8 article-title: Risks and benefits of drugs used in the management and prevention of gout publication-title: Drug Saf. – volume: 6 start-page: 2281 year: 2021 end-page: 2290 ident: bib33 article-title: Erythromycin loaded by tetrahedral framework nucleic acids are more antimicrobial sensitive against escherichia coli (e. Coli) publication-title: Bioactive Materials – volume: 66 start-page: 187 year: 2012 end-page: 195 ident: bib17 article-title: The role of proteins in neurodegenerative disease publication-title: Postepy Hig. Med. Dosw. – volume: 388 start-page: 2039 year: 2016 end-page: 2052 ident: bib1 publication-title: Lancet – volume: 33 start-page: 1238 year: 2012 end-page: 1244 ident: bib39 article-title: The cytotoxicity of cadmium-based quantum dots publication-title: Biomaterials – volume: 53 start-page: 475 year: 2015 end-page: 483 ident: bib20 article-title: Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in il-1β transgenic mice subjected to the lipopolysaccharide-induced sepsis publication-title: Biomaterials – volume: 4 start-page: 807 year: 2007 end-page: 818 ident: bib16 article-title: Bioavailability of curcumin: problems and promises publication-title: Mol. Pharm. – volume: 1 start-page: pe1 year: 2008 ident: bib50 article-title: Nuclear ubiquitin ligases, nf-κb degradation, and the control of inflammation publication-title: Sci. Signal. – volume: 34 start-page: 894 year: 1991 end-page: 903 ident: bib6 article-title: Monocyte-derived neutrophil chemotactic factor/interleukin-8 is a potential mediator of crystal-induced inflammation publication-title: Arthritis Rheum. – volume: 8 start-page: 125 year: 2011 ident: bib15 article-title: Curcumin is a potent modulator of microglial gene expression and migration publication-title: J. Neuroinflammation – volume: 114 start-page: 100 year: 2006 end-page: 109 ident: bib38 article-title: Toxicity of cationic lipids and cationic polymers in gene delivery publication-title: J. Contr. Release – volume: 75 start-page: 639 year: 2004 end-page: 653 ident: bib54 article-title: Inos-mediated nitric oxide production and its regulation publication-title: Life Sci. – volume: 11 start-page: 30631 year: 2019 end-page: 30639 ident: bib37 article-title: Cardioprotection of tetrahedral DNA nanostructures in myocardial ischemia-reperfusion injury publication-title: ACS Appl. Mater. Interfaces – volume: 48 start-page: 2075 year: 2015 ident: 10.1016/j.bioactmat.2021.06.003_bib21 article-title: Metal complexes of curcumin for cellular imaging, targeting, and photoinduced anticancer activity publication-title: Acc. Chem. Res. doi: 10.1021/acs.accounts.5b00127 – volume: 16 start-page: 4567 year: 2011 ident: 10.1016/j.bioactmat.2021.06.003_bib10 article-title: Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment publication-title: Molecules doi: 10.3390/molecules16064567 – volume: 114 start-page: 100 year: 2006 ident: 10.1016/j.bioactmat.2021.06.003_bib38 article-title: Toxicity of cationic lipids and cationic polymers in gene delivery publication-title: J. Contr. Release doi: 10.1016/j.jconrel.2006.04.014 – volume: 71 start-page: 991 year: 2019 ident: 10.1016/j.bioactmat.2021.06.003_bib2 article-title: Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: the national health and nutrition examination survey, 2007-2016 publication-title: Arthritis Rheum. doi: 10.1002/art.40807 – volume: 21 start-page: 102061 year: 2019 ident: 10.1016/j.bioactmat.2021.06.003_bib32 article-title: Targeted and effective glioblastoma therapy via aptamer-modified tetrahedral framework nucleic acid-paclitaxel nanoconjugates that can pass the blood brain barrier publication-title: Nanomedicine doi: 10.1016/j.nano.2019.102061 – volume: 10 start-page: 5457 year: 2018 ident: 10.1016/j.bioactmat.2021.06.003_bib34 article-title: Overcoming drug-resistant lung cancer by paclitaxel loaded tetrahedral DNA nanostructures publication-title: Nanoscale doi: 10.1039/C7NR09692E – volume: 20 start-page: 3602 year: 2020 ident: 10.1016/j.bioactmat.2021.06.003_bib24 article-title: Tetrahedral framework nucleic acids deliver antimicrobial peptides with improved effects and less susceptibility to bacterial degradation publication-title: Nano Lett. doi: 10.1021/acs.nanolett.0c00529 – start-page: 2007342 year: 2020 ident: 10.1016/j.bioactmat.2021.06.003_bib27 article-title: A framework nucleic acid based robotic nanobee for active targeting therapy publication-title: Adv. Funct. Mater. n/a – volume: 66 start-page: 187 year: 2012 ident: 10.1016/j.bioactmat.2021.06.003_bib17 article-title: The role of proteins in neurodegenerative disease publication-title: Postepy Hig. Med. Dosw. doi: 10.5604/17322693.991446 – volume: 29 start-page: 1912 year: 2008 ident: 10.1016/j.bioactmat.2021.06.003_bib40 article-title: Particle size-dependent organ distribution of gold nanoparticles after intravenous administration publication-title: Biomaterials doi: 10.1016/j.biomaterials.2007.12.037 – volume: 8 start-page: 125 year: 2011 ident: 10.1016/j.bioactmat.2021.06.003_bib15 article-title: Curcumin is a potent modulator of microglial gene expression and migration publication-title: J. Neuroinflammation doi: 10.1186/1742-2094-8-125 – volume: 18 start-page: 5652 year: 2018 ident: 10.1016/j.bioactmat.2021.06.003_bib26 article-title: Inhibiting methicillin-resistant staphylococcus aureus by tetrahedral DNA nanostructure-enabled antisense peptide nucleic acid delivery publication-title: Nano Lett. doi: 10.1021/acs.nanolett.8b02166 – volume: 6 start-page: 2281 year: 2021 ident: 10.1016/j.bioactmat.2021.06.003_bib33 article-title: Erythromycin loaded by tetrahedral framework nucleic acids are more antimicrobial sensitive against escherichia coli (e. Coli) publication-title: Bioactive Materials doi: 10.1016/j.bioactmat.2020.12.027 – volume: 8 start-page: 627 year: 2009 ident: 10.1016/j.bioactmat.2021.06.003_bib51 article-title: Idiopathic inflammatory myopathies and the classical nf-κb complex: current insights and implications for therapy publication-title: Autoimmun. Rev. doi: 10.1016/j.autrev.2009.02.026 – volume: 440 start-page: 237 year: 2006 ident: 10.1016/j.bioactmat.2021.06.003_bib4 article-title: Gout-associated uric acid crystals activate the nalp3 inflammasome publication-title: Nature doi: 10.1038/nature04516 – volume: 28 start-page: 1937 year: 2011 ident: 10.1016/j.bioactmat.2021.06.003_bib44 article-title: Multitargeting by curcumin as revealed by molecular interaction studies publication-title: Nat. Prod. Rep. doi: 10.1039/c1np00051a – volume: 14 year: 2018 ident: 10.1016/j.bioactmat.2021.06.003_bib59 article-title: Disease-triggered drug release effectively prevents acute inflammatory flare-ups, achieving reduced dosing publication-title: Small doi: 10.1002/smll.201800703 – volume: 1282 start-page: 133 year: 2009 ident: 10.1016/j.bioactmat.2021.06.003_bib12 article-title: Curcumin upregulates transcription factor nrf2, ho-1 expression and protects rat brains against focal ischemia publication-title: Brain Res. doi: 10.1016/j.brainres.2009.05.009 – volume: 19 start-page: 19 year: 2013 ident: 10.1016/j.bioactmat.2021.06.003_bib5 article-title: Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis publication-title: J. Clin. Rheumatol. doi: 10.1097/RHU.0b013e31827d8790 – volume: 4 start-page: 519 year: 2009 ident: 10.1016/j.bioactmat.2021.06.003_bib46 article-title: Sustained antibacterial activity of doxycycline-loaded poly(d,l-lactide-co-glycolide) and poly(epsilon-caprolactone) nanoparticles publication-title: Nanomedicine doi: 10.2217/nnm.09.28 – volume: 388 start-page: 2039 year: 2016 ident: 10.1016/j.bioactmat.2021.06.003_bib1 publication-title: Lancet doi: 10.1016/S0140-6736(16)00346-9 – volume: 82 start-page: 105 year: 2002 ident: 10.1016/j.bioactmat.2021.06.003_bib47 article-title: Residual polyvinyl alcohol associated with poly (d,l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake publication-title: J. Contr. Release doi: 10.1016/S0168-3659(02)00127-X – volume: 33 start-page: 1238 year: 2012 ident: 10.1016/j.bioactmat.2021.06.003_bib39 article-title: The cytotoxicity of cadmium-based quantum dots publication-title: Biomaterials doi: 10.1016/j.biomaterials.2011.10.070 – volume: 9 start-page: 3039 year: 2008 ident: 10.1016/j.bioactmat.2021.06.003_bib41 article-title: DNA nanotubes as combinatorial vehicles for cellular delivery publication-title: Biomacromolecules doi: 10.1021/bm800479e – volume: 10 start-page: 1508 year: 2015 ident: 10.1016/j.bioactmat.2021.06.003_bib43 article-title: Preparation and biomedical applications of programmable and multifunctional DNA nanoflowers publication-title: Nat. Protoc. doi: 10.1038/nprot.2015.078 – volume: 31 start-page: 6597 year: 2010 ident: 10.1016/j.bioactmat.2021.06.003_bib36 article-title: The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation publication-title: Biomaterials doi: 10.1016/j.biomaterials.2010.04.062 – volume: 11 start-page: 195 year: 2015 ident: 10.1016/j.bioactmat.2021.06.003_bib13 article-title: Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent publication-title: Nanomedicine doi: 10.1016/j.nano.2014.09.004 – volume: 1 start-page: pe1 year: 2008 ident: 10.1016/j.bioactmat.2021.06.003_bib50 article-title: Nuclear ubiquitin ligases, nf-κb degradation, and the control of inflammation publication-title: Sci. Signal. doi: 10.1126/stke.11pe1 – volume: 75 start-page: 639 year: 2004 ident: 10.1016/j.bioactmat.2021.06.003_bib54 article-title: Inos-mediated nitric oxide production and its regulation publication-title: Life Sci. doi: 10.1016/j.lfs.2003.10.042 – volume: 119 start-page: 6459 year: 2018 ident: 10.1016/j.bioactmat.2021.06.003_bib30 article-title: DNA nanotechnology-enabled drug delivery systems publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.7b00663 – volume: 2 start-page: 907 year: 2001 ident: 10.1016/j.bioactmat.2021.06.003_bib55 article-title: Nitric oxide and the immune response publication-title: Nat. Immunol. doi: 10.1038/ni1001-907 – volume: 130 start-page: 765 year: 2007 ident: 10.1016/j.bioactmat.2021.06.003_bib11 article-title: From exotic spice to modern drug? publication-title: Cell doi: 10.1016/j.cell.2007.08.024 – volume: 11 start-page: 30631 year: 2019 ident: 10.1016/j.bioactmat.2021.06.003_bib37 article-title: Cardioprotection of tetrahedral DNA nanostructures in myocardial ischemia-reperfusion injury publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.9b10645 – volume: 8 year: 2017 ident: 10.1016/j.bioactmat.2021.06.003_bib14 article-title: Nlrp3 inflammasome activation contributes to vsmc phenotypic transformation and proliferation in hypertension publication-title: Cell Death Dis. doi: 10.1038/cddis.2017.470 – volume: 25 start-page: 4386 year: 2013 ident: 10.1016/j.bioactmat.2021.06.003_bib42 article-title: Smart drug delivery nanocarriers with self-assembled DNA nanostructures publication-title: Adv. Mater. doi: 10.1002/adma.201300875 – volume: 10 start-page: 271 year: 2014 ident: 10.1016/j.bioactmat.2021.06.003_bib61 article-title: Optimizing current treatment of gout publication-title: Nat. Rev. Rheumatol. doi: 10.1038/nrrheum.2014.32 – volume: 11 start-page: 3567 year: 2005 ident: 10.1016/j.bioactmat.2021.06.003_bib22 article-title: Anti-cd19-targeted liposomal doxorubicin improves the therapeutic efficacy in murine b-cell lymphoma and ameliorates the toxicity of liposomes with varying drug release rates publication-title: Clin. Canc. Res. doi: 10.1158/1078-0432.CCR-04-2517 – volume: 8 start-page: 1213 year: 2014 ident: 10.1016/j.bioactmat.2021.06.003_bib19 article-title: Nanoparticles with dual responses to oxidative stress and reduced ph for drug release and anti-inflammatory applications publication-title: ACS Nano doi: 10.1021/nn4058787 – volume: 14 start-page: 6228 year: 2008 ident: 10.1016/j.bioactmat.2021.06.003_bib53 article-title: Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor κb by an akt-independent pathway publication-title: Clin. Canc. Res. doi: 10.1158/1078-0432.CCR-07-5177 – volume: 5 start-page: 5427 year: 2011 ident: 10.1016/j.bioactmat.2021.06.003_bib28 article-title: DNA cage delivery to mammalian cells publication-title: ACS Nano doi: 10.1021/nn2005574 – volume: 5 start-page: 433 year: 2010 ident: 10.1016/j.bioactmat.2021.06.003_bib45 article-title: Curcumin-encapsulated mepeg/pcl diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy publication-title: Nanomed doi: 10.2217/nnm.10.9 – volume: 24 start-page: 57 year: 2019 ident: 10.1016/j.bioactmat.2021.06.003_bib49 article-title: Advances in biological applications of self-assembled DNA tetrahedral nanostructures publication-title: Mater. Today doi: 10.1016/j.mattod.2018.08.002 – volume: 11 start-page: 252 year: 1994 ident: 10.1016/j.bioactmat.2021.06.003_bib8 article-title: Risks and benefits of drugs used in the management and prevention of gout publication-title: Drug Saf. doi: 10.2165/00002018-199411040-00004 – volume: 90 start-page: 831 year: 2014 ident: 10.1016/j.bioactmat.2021.06.003_bib62 article-title: Diagnosis, treatment, and prevention of gout publication-title: Am. Fam. Physician – volume: 253 start-page: 643 year: 2003 ident: 10.1016/j.bioactmat.2021.06.003_bib60 article-title: Adverse renal effects of anti-inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors publication-title: J. Intern. Med. doi: 10.1046/j.1365-2796.2003.01146.x – volume: 78 start-page: 2081 year: 2006 ident: 10.1016/j.bioactmat.2021.06.003_bib9 article-title: Multiple biological activities of curcumin: a short review publication-title: Life Sci. doi: 10.1016/j.lfs.2005.12.007 – volume: 4 start-page: 807 year: 2007 ident: 10.1016/j.bioactmat.2021.06.003_bib16 article-title: Bioavailability of curcumin: problems and promises publication-title: Mol. Pharm. doi: 10.1021/mp700113r – volume: 8 start-page: 6 year: 2020 ident: 10.1016/j.bioactmat.2021.06.003_bib35 article-title: Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis publication-title: Bone Res doi: 10.1038/s41413-019-0077-4 – volume: 6 start-page: 3051 year: 1992 ident: 10.1016/j.bioactmat.2021.06.003_bib56 article-title: Nitric oxide as a secretory product of mammalian cells publication-title: Faseb. J. doi: 10.1096/fasebj.6.12.1381691 – volume: 5 start-page: 69 year: 2019 ident: 10.1016/j.bioactmat.2021.06.003_bib7 publication-title: Nat Rev Dis Primers doi: 10.1038/s41572-019-0115-y – volume: 100 year: 1999 ident: 10.1016/j.bioactmat.2021.06.003_bib58 article-title: Oxidative stress induces nf-kappab nuclear translocation without degradation of ikappabalpha publication-title: Circulation – volume: 34 start-page: 894 year: 1991 ident: 10.1016/j.bioactmat.2021.06.003_bib6 article-title: Monocyte-derived neutrophil chemotactic factor/interleukin-8 is a potential mediator of crystal-induced inflammation publication-title: Arthritis Rheum. doi: 10.1002/art.1780340716 – volume: 9 start-page: 2550 year: 2018 ident: 10.1016/j.bioactmat.2021.06.003_bib48 article-title: Oridonin is a covalent nlrp3 inhibitor with strong anti-inflammasome activity publication-title: Nat. Commun. doi: 10.1038/s41467-018-04947-6 – volume: 15 start-page: 2728 year: 2020 ident: 10.1016/j.bioactmat.2021.06.003_bib25 article-title: Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment publication-title: Nat. Protoc. doi: 10.1038/s41596-020-0355-z – volume: 8 start-page: 76 year: 2014 ident: 10.1016/j.bioactmat.2021.06.003_bib18 article-title: Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in alzheimer's disease model via canonical wnt/β-catenin pathway publication-title: ACS Nano doi: 10.1021/nn405077y – volume: 63 start-page: 185 year: 2012 ident: 10.1016/j.bioactmat.2021.06.003_bib23 article-title: Nanoparticle delivery of cancer drugs publication-title: Annu. Rev. Med. doi: 10.1146/annurev-med-040210-162544 – volume: 53 start-page: 475 year: 2015 ident: 10.1016/j.bioactmat.2021.06.003_bib20 article-title: Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in il-1β transgenic mice subjected to the lipopolysaccharide-induced sepsis publication-title: Biomaterials doi: 10.1016/j.biomaterials.2015.02.116 – volume: 71 start-page: 180 year: 2012 ident: 10.1016/j.bioactmat.2021.06.003_bib63 article-title: Safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the monoclonal antibody ask8007 blocking osteopontin in patients with rheumatoid arthritis: a randomised, placebo controlled, proof-of-concept study publication-title: Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2011-200298 – volume: 11 start-page: 39525 year: 2019 ident: 10.1016/j.bioactmat.2021.06.003_bib29 article-title: Enhanced efficacy of temozolomide loaded by a tetrahedral framework DNA nanoparticle in the therapy for glioblastoma publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.9b13829 – volume: 11 start-page: 6850 year: 2019 ident: 10.1016/j.bioactmat.2021.06.003_bib31 article-title: Tetrahedral DNA nanostructure-delivered dnazyme for gene silencing to suppress cell growth publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.8b22444 – volume: 9 start-page: 2736 year: 1995 ident: 10.1016/j.bioactmat.2021.06.003_bib52 article-title: Constitutive nf-kappa b activation, enhanced granulopoiesis, and neonatal lethality in i kappa b alpha-deficient mice publication-title: Genes Dev. doi: 10.1101/gad.9.22.2736 – volume: 60 start-page: 281 year: 2009 ident: 10.1016/j.bioactmat.2021.06.003_bib3 article-title: Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal–induced murine peritoneal model of acute gout publication-title: Arthritis Rheum. doi: 10.1002/art.24185 – volume: 36 start-page: 161 year: 2015 ident: 10.1016/j.bioactmat.2021.06.003_bib57 article-title: Nitric oxide synthase in innate and adaptive immunity: an update publication-title: Trends Immunol. doi: 10.1016/j.it.2015.01.003 |
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| Title | Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis |
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