Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy

• Published in: Scientific reports Vol. 13; no. 1; pp. 15500 - 15
• Main Authors: González-Peñas, Javier, de Hoyos, Lucía, Díaz-Caneja, Covadonga M., Andreu-Bernabeu, Álvaro, Stella, Carol, Gurriarán, Xaquín, Fañanás, Lourdes, Bobes, Julio, González-Pinto, Ana, Crespo-Facorro, Benedicto, Martorell, Lourdes, Vilella, Elisabet, Muntané, Gerard, Molto, María Dolores, Gonzalez-Piqueras, Jose Carlos, Parellada, Mara, Arango, Celso, Costas, Javier
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.09.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/181/2474; 631/208/1515; 631/208/205/2138; 631/208/212/2304; Alleles; Evolution; Fertility; Genomes; Heritability; Human populations; Humanities and Social Sciences; Life expectancy; Life span; Mental disorders; multidisciplinary; Natural selection; Phenotypes; Pleiotropy; Positive selection; Schizophrenia; Science; Science (multidisciplinary)

Schizophrenia is a debilitating psychiatric disorder associated with a reduced fertility and decreased life expectancy, yet common predisposing variation substantially contributes to the onset of the disorder, which poses an evolutionary paradox. Previous research has suggested balanced selection, a...