Extracellular vesicles from subjects with COPD modulate cancer initiating cells phenotype through HIF-1α shuttling

• Published in: Cell death & disease Vol. 14; no. 10; pp. 681 - 12
• Main Authors: Petraroia, Ilaria, Ghidotti, Patrizia, Bertolini, Giulia, Pontis, Francesca, Roz, Luca, Balsamo, Melissa, Suatoni, Paola, Pastorino, Ugo, Ferretti, Anna Maria, Sozzi, Gabriella, Fortunato, Orazio
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.10.2023; Springer Nature B.V; Nature Publishing Group
• Subjects: 13; 13/21; 13/31; 14/28; 38/39; 38/77; 38/89; 42/109; 631/67/1612/1350; 631/67/71; 82/1; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell activation; Cell Biology; Cell Culture; Chronic obstructive pulmonary disease; CXCR4 protein; Endothelial cells; Epithelial cells; Extracellular vesicles; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-inducible factor 1a; Immunology; Life Sciences; Lung cancer; Lung diseases; Metastases; Obstructive lung disease; p53 Protein; Phenotypes; Risk factors; Telomerase reverse transcriptase; Ultracentrifugation

Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling, causing remodeling of surrounding microenvironmental cells also modulating the release and cargo of their extracellular vesicles (EVs). We aimed to evaluat...