Investigating the link of ACAD10 deficiency to type 2 diabetes mellitus

• Published in: Journal of inherited metabolic disease Vol. 41; no. 1; pp. 49 - 57
• Main Authors: Bloom, Kaitlyn, Mohsen, Al-Walid, Karunanidhi, Anuradha, El Demellawy, Dina, Reyes-Múgica, Miguel, Wang, Yudong, Ghaloul-Gonzalez, Lina, Otsubo, Chikara, Tobita, Kimi, Muzumdar, Radhika, Gong, Zhenwei, Tas, Emir, Basu, Shrabani, Chen, Jie, Bennett, Michael, Hoppel, Charles, Vockley, Jerry
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.01.2018; Blackwell Publishing Ltd
• Subjects: Abdominal Fat - enzymology; Abdominal Fat - physiopathology; Acyl-CoA dehydrogenase; Acyl-CoA Dehydrogenase - genetics; Adipose tissue; Adiposity; Animals; Biochemistry; Blood Glucose - metabolism; C-Terminus; Dehydrogenation; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - pathology; Diabetes Mellitus, Type 2 - physiopathology; Disease Models, Animal; Genetic Predisposition to Disease; Glucose tolerance; Human Genetics; Inflammation; Insulin; Insulin - blood; Insulin resistance; Insulin Resistance - genetics; Internal Medicine; Lipid Metabolism, Inborn Errors - enzymology; Lipid Metabolism, Inborn Errors - genetics; Lipid Metabolism, Inborn Errors - pathology; Lipid Metabolism, Inborn Errors - physiopathology; Liver; Liver - enzymology; Liver - pathology; Medicine; Medicine & Public Health; Metabolic Diseases; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Minority & ethnic groups; Mitochondria; Mitochondria, Muscle - enzymology; Mitochondria, Muscle - pathology; Muscle, Skeletal - enzymology; Muscle, Skeletal - pathology; Non-alcoholic Fatty Liver Disease - enzymology; Non-alcoholic Fatty Liver Disease - genetics; Non-alcoholic Fatty Liver Disease - pathology; Obesity, Abdominal - enzymology; Obesity, Abdominal - genetics; Obesity, Abdominal - physiopathology; Original Article; Pediatrics; Phenotype; Rhabdomyolysis; Rhabdomyolysis - enzymology; Rhabdomyolysis - genetics; Rhabdomyolysis - pathology; Skeletal muscle; Studies

The Native American Pima population has the highest incidence of insulin resistance (IR) and type 2 diabetes mellitus (T2DM) of any reported population, but the pathophysiologic mechanism is unknown. Genetic studies in Pima Indians have linked acyl-CoA dehydrogenase 10 ( ACAD10 ) gene polymorphisms,...