CONTROLLED DRUG RELEASE BY ULTRASOUND IRRADIATION

Sustained release systems were made by incorporating 5-fluorouracil (5-FU) in an ethylene-vinyl alcohol copolymer. When exposed to aqueous medium, the delivery systems released the drug slowly and continuously. Upon exposure to ultrasound, the drug was released at a much higher rate. Release rates r...

Full description

Saved in:
Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 33; no. 1; pp. 428 - 431
Main Authors Miyazaki, Shozo, Hou, WeiMin, Takada, Masahiko
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1985
Maruzen
Subjects
5-fluorouracil
Antineoplastic agents
Biological and medical sciences
Delayed-Action Preparations
Fluorouracil - administration & dosage
General aspects
Medical sciences
Pharmacology. Drug treatments
Ultrasonics
Antineoplastic agent
Investigation method
Controlled release form
Ethylene copolymer
Irradiation
Vinyl alcohol copolymer
Active ingredient
Drug delivery system
Ultrasound
Release
Online AccessGet full text

Cover

More Information
Summary:Sustained release systems were made by incorporating 5-fluorouracil (5-FU) in an ethylene-vinyl alcohol copolymer. When exposed to aqueous medium, the delivery systems released the drug slowly and continuously. Upon exposure to ultrasound, the drug was released at a much higher rate. Release rates returned to base line levels when the ultrasound irradiation was discontinued. This study demonstrated that release rates of 5-FU from polymers can be increased at desired times by external ultrasound irradiation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.33.428