Increased expression of the testicular estrogen receptor alpha in adult mice exposed to low doses of methiocarb

• Published in: Journal of applied toxicology Vol. 29; no. 5; pp. 446 - 451
• Main Authors: Han, Jiyou, Park, Mira, Kim, Jae-Hong, Kim, Ahyoung, Won, Miae, Lee, Dong Ryul, Ko, Jeong-Jae, Yoon, Ho, Sim, Se-Hoon, Lee, Kangseok, Bae, Jeehyeon
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.07.2009; Wiley
• Subjects: 3,5‐dimethyl‐1,4‐methylthiophenyl‐N‐methylcarbamate; 4-methylthiophenyl-N-methylcarbamate; 5-dimethyl-1; Animals; Biological and medical sciences; Blotting, Western; Body Weight - drug effects; CASA; Dose-Response Relationship, Drug; endocrine disrupter; Endocrine Disruptors - toxicity; estrogen receptor; Estrogen Receptor alpha - biosynthesis; Image Processing, Computer-Assisted; Kidney - drug effects; Liver - drug effects; Male; male reproduction; Medical sciences; methiocarb; Methiocarb - toxicity; Mice; Mice, Inbred DBA; Organ Size - drug effects; Sperm Motility - drug effects; spermatogenesis; Spermatogenesis - drug effects; Spermatozoa - drug effects; Spermatozoa - metabolism; testis; Testis - drug effects; Testis - metabolism; Toxicology; Estrogen receptor; male reproduction; Spermatogenesis; Low dose; Rodentia; Male; Endocrine disruptor; testis; Testicle; 3,5-dimethyl-1,4-methylthiophenyl-N-methylcarbamate; methiocarb; Male genital system; Vertebrata; Reproduction; Mammalia; CASA; endocrine disrupter; Mouse; Adult animal; Computer aid; Hormonal receptor

Methiocarb is a widely used carbamate pesticide and a suspected endocrine disrupter. The objective of this study was to examine the in vivo effects of methiocarb at low doses on testicular expression of steroid receptors, spermatogenesis and sperm quality in adult mice. Eighteen‐week‐old DBA/2 males...