NO as a signalling molecule in the nervous system

• Published in: British journal of pharmacology Vol. 135; no. 5; pp. 1079 - 1095
• Main Author: Esplugues, Juan V
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2002; Nature Publishing
• Subjects: Biological and medical sciences; Calcium - metabolism; Calcium Channels - metabolism; Central Nervous System - metabolism; CNS; Cyclic GMP - metabolism; Enzyme Activation; Medical sciences; NANC; Neurons - metabolism; neurotransmission; Nitric Oxide - biosynthesis; Nitric Oxide Synthase - biosynthesis; Nitric Oxide Synthase Type I; NOS synthases; Receptors, N-Methyl-D-Aspartate - agonists; Review; Signal Transduction; signalling; stroke; Synaptic Transmission

The discovery that nitric oxide (NO) functions as a signalling molecule in the nervous system has radically changed the concept of neural communication. Indeed, the adoption of the term nitrergic for nerves whose transmitter function depends on the release of NO or for transmission mechanisms brough...