Circulating MicroRNAs Identified in a Genome-Wide Serum MicroRNA Expression Analysis as Noninvasive Biomarkers for Endometriosis

• Published in: The journal of clinical endocrinology and metabolism Vol. 98; no. 1; pp. 281 - 289
• Main Authors: Wang, Wen-Tao, Zhao, Ya-Nan, Han, Bo-Wei, Hong, Shun-Jia, Chen, Yue-Qin
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.01.2013; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adult; Biological and medical sciences; Biomarkers; Biomarkers - analysis; Biomarkers - blood; Biomarkers - metabolism; Case-Control Studies; Endocrinopathies; Endometriosis; Endometriosis - blood; Endometriosis - diagnosis; Endometriosis - genetics; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling; Genome-Wide Association Study; Genomic analysis; Humans; Medical sciences; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; MicroRNAs - metabolism; MicroRNAs - physiology; Middle Aged; miRNA; Sensitivity and Specificity; Severity of Illness Index; Uterine Diseases - blood; Uterine Diseases - diagnosis; Uterine Diseases - genetics; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Young Adult; Obesity; Nutrition; Nutrition disorder; Biological marker; Endometriosis; Metabolic diseases; Identification; Gene expression; Female genital diseases; Non invasive method; Uterine diseases; Serum; Genome; Endocrinology; Nutritional status

Context:There is currently no reliable noninvasive biomarker for the clinical diagnosis of endometriosis. Previous analyses have reported that circulating microRNAs (miRNAs) can serve as biomarkers for a number of diseases.Objective:The study aims to detect the serum miRNAs that are differentially e...