Ion‐channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells

• Published in: Physiological reports Vol. 9; no. 15; pp. e14963 - n/a
• Main Authors: Mishra, Poonam, Narayanan, Rishikesh
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2021; John Wiley and Sons Inc; Wiley
• Subjects: Action potential; Animals; Barium; Barium - pharmacology; Bee Venoms - pharmacology; degeneracy; Excitability; Firing rate; Granule cells; HCN channel; Hippocampus; Hippocampus - cytology; Hippocampus - drug effects; Hippocampus - physiology; Hyperpolarization; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - antagonists & inhibitors; Hypotheses; intrinsic excitability; inward rectifier potassium channel; Ion channels; Male; Neurons - cytology; Neurons - drug effects; Neurons - physiology; Original; patch‐clamp electrophysiology; persistent sodium channel; Physiology; Potassium; Potassium channels (inwardly-rectifying); Potassium Channels - chemistry; Rats; Rats, Sprague-Dawley; Signatures; Sodium Channels - chemistry; patch-clamp electrophysiology; HCN channel; degeneracy; persistent sodium channel; hippocampus; intrinsic excitability; inward rectifier potassium channel

Degeneracy, the ability of multiple structural components to elicit the same characteristic functional properties, constitutes an elegant mechanism for achieving biological robustness. In this study, we sought electrophysiological signatures for the expression of ion‐channel degeneracy in the emerge...