Toll‐like receptors: the swiss army knife of immunity and vaccine development

• Published in: Clinical & translational immunology Vol. 5; no. 5; pp. e85 - n/a
• Main Authors: Dowling, Jennifer K, Mansell, Ashley
• Format: Journal Article
• Language: English
• Published: Australia Nature Publishing Group 01.05.2016; John Wiley & Sons, Inc
• Subjects: Adaptive immunity; Adenomatous polyposis coli; Adjuvants; Antigen-presenting cells; Antigens; Cancer; Cell activation; Chemokines; Chronic fatigue syndrome; Cytokines; Dendritic cells; Deoxyribonucleic acid; Disease; DNA; Hepatitis; Human papillomavirus; Immune system; Immunological diseases; Inflammation; Influenza; Ischemia; Kinases; Ligands; Lipids; Localization; Lymphocytes T; Melanoma; Oligomerization; Pattern recognition receptors; Pharmaceuticals; Proteins; Respiratory syncytial virus; Retinoic acid; Review; Signal transduction; Vaccine development; Vaccines; Viruses

Innate immune cells have a critical role in defense against infection and disease. Central to this is the broad specificity with which they can detect pathogen‐associated patterns and danger‐associated patterns via the pattern recognition receptors (PRRs) they express. Several families of PRRs have...