Impaired long-term potentiation-like cortical plasticity in presymptomatic genetic frontotemporal dementia

• Published in: Annals of neurology Vol. 80; no. 3; pp. 472 - 476
• Main Authors: Benussi, Alberto, Cosseddu, Maura, Filareto, Ilaria, Dell'Era, Valentina, Archetti, Silvana, Sofia Cotelli, Maria, Micheli, Anna, Padovani, Alessandro, Borroni, Barbara
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2016; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Biomarkers; C9orf72 Protein; Cerebral Cortex - physiopathology; Cortex; Dementia; Dementia disorders; Female; Frontotemporal dementia; Frontotemporal Dementia - genetics; Frontotemporal Dementia - physiopathology; Granulin; Heterozygote; Humans; Intercellular Signaling Peptides and Proteins - genetics; Long-Term Potentiation - physiology; Magnetic fields; Male; Middle Aged; Mutation; Neural plasticity; Potentiation; Prodromal Symptoms; Proteins - genetics; Single-Blind Method; Transcranial magnetic stimulation; Transcranial Magnetic Stimulation - methods

Neurophysiological biomarkers were assessed using a transcranial magnetic stimulation multiparadigm approach in 13 presymptomatic (n = 13 Granulin) and 14 symptomatic (n = 11 Granulin, n = 3 C9orf72) subjects with a pathogenic mutation for frontotemporal dementia (FTD). Intracortical facilitation an...