Medullary serotonergic neurones modulate the ventilatory response to hypercapnia, but not hypoxia in conscious rats
Serotonergic neurones in the mammalian medullary raphe region (MRR) have been implicated in central chemoreception and the modulation of the ventilatory response to hypercapnia, and may also be involved in the ventilatory response to hypoxia. In this study, we ask whether ventilatory responses acros...
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| Published in | The Journal of physiology Vol. 566; no. 2; pp. 543 - 557 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
9600 Garsington Road , Oxford , OX4 2DQ , UK
The Physiological Society
15.07.2005
Blackwell Science Ltd Blackwell Science Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Serotonergic neurones in the mammalian medullary raphe region (MRR) have been implicated in central chemoreception and the
modulation of the ventilatory response to hypercapnia, and may also be involved in the ventilatory response to hypoxia. In
this study, we ask whether ventilatory responses across arousal states are affected when the 5-hydroxytryptamine 1A receptor
(5-HT 1A ) agonist ( R )-(+)-8-hydroxy-2(di- n -propylamino)tetralin (DPAT) is microdialysed into the MRR of the unanaesthetized adult rat. Microdialysis of 1, 10 and 30
m m DPAT into the MRR significantly decreased absolute ventilation values during 7% CO 2 breathing by 21%, 19% and 30%, respectively, in wakefulness compared to artificial cerebrospinal fluid (aCSF) microdialysis,
due to decreases in tidal volume ( V T ) and not in frequency ( f ), similar to what occurred during non-rapid eye movement (NREM) sleep. The concentration-dependence of the hypercapnic ventilatory
effect might be due to differences in tissue distribution of DPAT. DPAT (30 m m ) changed room air breathing pattern by increasing f and decreasing V T . As evidenced by a sham control group, repeated experimentation and microdialysis of aCSF alone had no effect on the ventilatory
response to 7% CO 2 during wakefulness or sleep. Unlike during hypercapnia, microdialysis of 30 m m DPAT into the MRR did not change the ventilatory response to 10% O 2 . Additionally, 10 and 30 m m DPAT MRR microdialysis decreased body temperature, and 30 m m DPAT increased the percentage of experimental time in wakefulness. We conclude that serotonergic activity in the MRR plays
a role in the ventilatory response to hypercapnia, but not to hypoxia, and that MRR 5-HT 1A receptors are also involved in thermoregulation and arousal. |
|---|---|
| AbstractList | Serotonergic neurones in the mammalian medullary raphe region (MRR) have been implicated in central chemoreception and the modulation of the ventilatory response to hypercapnia, and may also be involved in the ventilatory response to hypoxia. In this study, we ask whether ventilatory responses across arousal states are affected when the 5-hydroxytryptamine 1A receptor (5-HT
1A
) agonist (
R
)-(+)-8-hydroxy-2(di-
n
-propylamino)tetralin (DPAT) is microdialysed into the MRR of the unanaesthetized adult rat. Microdialysis of 1, 10 and 30 m
m
DPAT into the MRR significantly decreased absolute ventilation values
during 7% CO
2
breathing by 21%, 19% and 30%, respectively, in wakefulness compared to artificial cerebrospinal fluid (aCSF) microdialysis, due to decreases in tidal volume (
V
T
) and not in frequency (
f
), similar to what occurred during non-rapid eye movement (NREM) sleep. The concentration-dependence of the hypercapnic ventilatory effect might be due to differences in tissue distribution of DPAT. DPAT (30 m
m
) changed room air breathing pattern by increasing
f
and decreasing
V
T
. As evidenced by a sham control group, repeated experimentation and microdialysis of aCSF alone had no effect on the ventilatory response to 7% CO
2
during wakefulness or sleep. Unlike during hypercapnia, microdialysis of 30 m
m
DPAT into the MRR did not change the ventilatory response to 10% O
2
. Additionally, 10 and 30 m
m
DPAT MRR microdialysis decreased body temperature, and 30 m
m
DPAT increased the percentage of experimental time in wakefulness. We conclude that serotonergic activity in the MRR plays a role in the ventilatory response to hypercapnia, but not to hypoxia, and that MRR 5-HT
1A
receptors are also involved in thermoregulation and arousal. Serotonergic neurones in the mammalian medullary raphe region (MRR) have been implicated in central chemoreception and the modulation of the ventilatory response to hypercapnia, and may also be involved in the ventilatory response to hypoxia. In this study, we ask whether ventilatory responses across arousal states are affected when the 5-hydroxytryptamine 1A receptor (5-HT1A) agonist (R)-(+)-8-hydroxy-2(di-n-propylamino)tetralin (DPAT) is microdialysed into the MRR of the unanaesthetized adult rat. Microdialysis of 1, 10 and 30 mM DPAT into the MRR significantly decreased absolute ventilation values(VE) during 7% CO2 breathing by 21%, 19% and 30%, respectively, in wakefulness compared to artificial cerebrospinal fluid (aCSF) microdialysis, due to decreases in tidal volume (VT) and not in frequency (f), similar to what occurred during non-rapid eye movement (NREM) sleep. The concentration-dependence of the hypercapnic ventilatory effect might be due to differences in tissue distribution of DPAT. DPAT (30 mM) changed room air breathing pattern by increasing f and decreasing VT. As evidenced by a sham control group, repeated experimentation and microdialysis of aCSF alone had no effect on the ventilatory response to 7% CO2 during wakefulness or sleep. Unlike during hypercapnia, microdialysis of 30 mM DPAT into the MRR did not change the ventilatory response to 10% O2. Additionally, 10 and 30 mM DPAT MRR microdialysis decreased body temperature, and 30 mM DPAT increased the percentage of experimental time in wakefulness. We conclude that serotonergic activity in the MRR plays a role in the ventilatory response to hypercapnia, but not to hypoxia, and that MRR 5-HT1A receptors are also involved in thermoregulation and arousal. Serotonergic neurones in the mammalian medullary raphe region (MRR) have been implicated in central chemoreception and the modulation of the ventilatory response to hypercapnia, and may also be involved in the ventilatory response to hypoxia. In this study, we ask whether ventilatory responses across arousal states are affected when the 5‐hydroxytryptamine 1A receptor (5‐HT1A) agonist (R)‐(+)‐8‐hydroxy‐2(di‐n‐propylamino)tetralin (DPAT) is microdialysed into the MRR of the unanaesthetized adult rat. Microdialysis of 1, 10 and 30 mm DPAT into the MRR significantly decreased absolute ventilation values during 7% CO2 breathing by 21%, 19% and 30%, respectively, in wakefulness compared to artificial cerebrospinal fluid (aCSF) microdialysis, due to decreases in tidal volume (VT) and not in frequency (f), similar to what occurred during non‐rapid eye movement (NREM) sleep. The concentration‐dependence of the hypercapnic ventilatory effect might be due to differences in tissue distribution of DPAT. DPAT (30 mm) changed room air breathing pattern by increasing f and decreasing VT. As evidenced by a sham control group, repeated experimentation and microdialysis of aCSF alone had no effect on the ventilatory response to 7% CO2 during wakefulness or sleep. Unlike during hypercapnia, microdialysis of 30 mm DPAT into the MRR did not change the ventilatory response to 10% O2. Additionally, 10 and 30 mm DPAT MRR microdialysis decreased body temperature, and 30 mm DPAT increased the percentage of experimental time in wakefulness. We conclude that serotonergic activity in the MRR plays a role in the ventilatory response to hypercapnia, but not to hypoxia, and that MRR 5‐HT1A receptors are also involved in thermoregulation and arousal. Serotonergic neurones in the mammalian medullary raphe region (MRR) have been implicated in central chemoreception and the modulation of the ventilatory response to hypercapnia, and may also be involved in the ventilatory response to hypoxia. In this study, we ask whether ventilatory responses across arousal states are affected when the 5-hydroxytryptamine 1A receptor (5-HT sub(1A)) agonist (R)-(+)-8-hydroxy-2(di-n-propylamino)tetralin (DPAT) is microdialysed into the MRR of the unanaesthetized adult rat. Microdialysis of 1, 10 and 30 mM DPAT into the MRR significantly decreased absolute ventilation values {tjp_960_mu1} during 7% CO sub(2) breathing by 21%, 19% and 30%, respectively, in wakefulness compared to artificial cerebrospinal fluid (aCSF) microdialysis, due to decreases in tidal volume (V sub(T)) and not in frequency (f), similar to what occurred during non-rapid eye movement (NREM) sleep. The concentration-dependence of the hypercapnic ventilatory effect might be due to differences in tissue distribution of DPAT. DPAT (30 mM) changed room air breathing pattern by increasing f and decreasing V sub(T). As evidenced by a sham control group, repeated experimentation and microdialysis of aCSF alone had no effect on the ventilatory response to 7% CO sub(2) during wakefulness or sleep. Unlike during hypercapnia, microdialysis of 30 mM DPAT into the MRR did not change the ventilatory response to 10% O sub(2). Additionally, 10 and 30 mM DPAT MRR microdialysis decreased body temperature, and 30 mM DPAT increased the percentage of experimental time in wakefulness. We conclude that serotonergic activity in the MRR plays a role in the ventilatory response to hypercapnia, but not to hypoxia, and that MRR 5-HT sub(1A) receptors are also involved in thermoregulation and arousal. Serotonergic neurones in the mammalian medullary raphe region (MRR) have been implicated in central chemoreception and the modulation of the ventilatory response to hypercapnia, and may also be involved in the ventilatory response to hypoxia. In this study, we ask whether ventilatory responses across arousal states are affected when the 5-hydroxytryptamine 1A receptor (5-HT 1A ) agonist ( R )-(+)-8-hydroxy-2(di- n -propylamino)tetralin (DPAT) is microdialysed into the MRR of the unanaesthetized adult rat. Microdialysis of 1, 10 and 30 m m DPAT into the MRR significantly decreased absolute ventilation values during 7% CO 2 breathing by 21%, 19% and 30%, respectively, in wakefulness compared to artificial cerebrospinal fluid (aCSF) microdialysis, due to decreases in tidal volume ( V T ) and not in frequency ( f ), similar to what occurred during non-rapid eye movement (NREM) sleep. The concentration-dependence of the hypercapnic ventilatory effect might be due to differences in tissue distribution of DPAT. DPAT (30 m m ) changed room air breathing pattern by increasing f and decreasing V T . As evidenced by a sham control group, repeated experimentation and microdialysis of aCSF alone had no effect on the ventilatory response to 7% CO 2 during wakefulness or sleep. Unlike during hypercapnia, microdialysis of 30 m m DPAT into the MRR did not change the ventilatory response to 10% O 2 . Additionally, 10 and 30 m m DPAT MRR microdialysis decreased body temperature, and 30 m m DPAT increased the percentage of experimental time in wakefulness. We conclude that serotonergic activity in the MRR plays a role in the ventilatory response to hypercapnia, but not to hypoxia, and that MRR 5-HT 1A receptors are also involved in thermoregulation and arousal. |
| Author | Aihua Li Natalie C Taylor Eugene E Nattie |
| Author_xml | – sequence: 1 givenname: Natalie C. surname: Taylor fullname: Taylor, Natalie C. – sequence: 2 givenname: Aihua surname: Li fullname: Li, Aihua – sequence: 3 givenname: Eugene E. surname: Nattie fullname: Nattie, Eugene E. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15878953$$D View this record in MEDLINE/PubMed |
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| Snippet | Serotonergic neurones in the mammalian medullary raphe region (MRR) have been implicated in central chemoreception and the
modulation of the ventilatory... Serotonergic neurones in the mammalian medullary raphe region (MRR) have been implicated in central chemoreception and the modulation of the ventilatory... |
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| SubjectTerms | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Animals Body Temperature - physiology Electroencephalography Electromyography Hypercapnia - pathology Hypercapnia - physiopathology Hypoxia - pathology Hypoxia - physiopathology Integrative Physiology Male Medulla Oblongata - cytology Medulla Oblongata - pathology Medulla Oblongata - physiology Microdialysis Neurons - physiology Oxygen Consumption - physiology Plethysmography, Whole Body Raphe Nuclei - cytology Raphe Nuclei - pathology Raphe Nuclei - physiology Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT1A - drug effects Receptor, Serotonin, 5-HT1A - metabolism Respiratory Mechanics - physiology Serotonin - physiology Serotonin Receptor Agonists - pharmacology Sleep Stages - physiology Wakefulness - physiology |
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| Title | Medullary serotonergic neurones modulate the ventilatory response to hypercapnia, but not hypoxia in conscious rats |
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