Design, synthesis, and in silico studies of quinoline-based-benzo[d]imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors

• Published in: Scientific reports Vol. 12; no. 1; p. 14019
• Main Authors: Noori, Milad, Davoodi, Ali, Iraji, Aida, Dastyafteh, Navid, Khalili, Minoo, Asadi, Mehdi, Mohammadi Khanaposhtani, Maryam, Mojtabavi, Somayeh, Dianatpour, Mehdi, Faramarzi, Mohammad Ali, Larijani, Bagher, Amanlou, Massoud, Mahdavi, Mohammad
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.08.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154; 631/154/309; 631/154/309/2144; 631/92; 631/92/607; Acarbose; Design; Diabetes; Diabetes mellitus; Enzymes; Glucose; Humanities and Social Sciences; Hyperglycemia; Imidazole; Metabolism; multidisciplinary; Pharmacy; Research centers; Science; Science (multidisciplinary); α-Glucosidase

In this study, 18 novel quinoline-based-benzo[d]imidazole derivatives were synthesized and screened for their α-glucosidase inhibitory potential. All compounds in the series except 9q showed a significant α-glucosidase inhibition with IC 50 values in the range of 3.2 ± 0.3–185.0 ± 0.3 µM, as compare...