Ropinirole, a New ALS Drug Candidate Developed Using iPSCs

• Published in: Trends in pharmacological sciences (Regular ed.) Vol. 41; no. 2; pp. 99 - 109
• Main Authors: Okano, Hideyuki, Yasuda, Daisuke, Fujimori, Koki, Morimoto, Satoru, Takahashi, Shinichi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2020
• Subjects: amyotrophic lateral sclerosis; disease modeling; drug repositioning; induced pluripotent stem cells; ropinirole; induced pluripotent stem cells; ropinirole; drug repositioning; amyotrophic lateral sclerosis; disease modeling

Induced pluripotent stem cells (iPSCs) are increasingly used in the study of disease mechanisms and the development of effective disease-modifying therapies for neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Recently, three candidate anti-ALS drugs – ropinirole (ROPI), re...