Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish

• Published in: Pharmacology, biochemistry and behavior Vol. 103; no. 4; pp. 792 - 813
• Main Authors: Irons, T.D., Kelly, P.E., Hunter, D.L., MacPhail, R.C., Padilla, S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2013
• Subjects: Acute; Animals; Dopamine; Dopamine Agents - administration & dosage; Dopamine Agonists - administration & dosage; Dopamine Antagonists - administration & dosage; Dose-Response Relationship, Drug; Larva - drug effects; Larva - physiology; Locomotor activity; Models, Animal; Motor Activity - drug effects; Motor Activity - physiology; Receptor; Receptors, Dopamine - physiology; Zebrafish; Zebrafish - physiology; Zebrafish; Dopamine; Receptor; Acute; Locomotor activity

Altered dopaminergic signaling causes behavioral changes in mammals. In general, dopaminergic receptor agonists increase locomotor activity, while antagonists decrease locomotor activity. In order to determine if zebrafish (a model organism becoming popular in pharmacology and toxicology) respond si...