WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression

• Published in: Nature communications Vol. 12; no. 1; pp. 3500 - 16
• Main Authors: Wu, Man, Xia, Xueqing, Hu, Jiemiao, Fowlkes, Natalie Wall, Li, Shulin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.06.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Phosphatidylinositol 3-kinase; 13/1; 13/106; 13/109; 13/31; 13/44; 13/51; 13/89; 13/95; 14/63; 38; 49/88; 49/91; 631/67/1504/1610/4029; 631/67/580; 64/110; 64/60; 692/4028/67/1504/1610; 82/29; 82/58; 82/80; AKT protein; Animal models; Antitumor activity; Cancer; Cancer immunotherapy; CD8 antigen; Hepatocellular carcinoma; Hepatocytes; Humanities and Social Sciences; Immune response; Immune system; Immunosurveillance; Interleukin 27; Liver cancer; Lymphocytes; Lymphocytes T; multidisciplinary; PD-L1 protein; Receptors; Science; Science (multidisciplinary); Transcription; Tumor suppressor genes; Tumors

WSX1, a receptor subunit for IL-27, is widely expressed in immune cells and closely involved in immune response, but its function in nonimmune cells remains unknown. Here we report that WSX1 is highly expressed in human hepatocytes but downregulated in hepatocellular carcinoma (HCC) cells. Using NRA...