Oxepinamide F biosynthesis involves enzymatic d-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration

• Published in: Nature communications Vol. 11; no. 1; pp. 4914 - 10
• Main Authors: Zheng, Liujuan, Wang, Haowen, Fan, Aili, Li, Shu-Ming
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 38/22; 38/43; 38/77; 38/90; 45/29; 631/45/173; 631/45/611; 631/92/349/977; 631/92/60; 82/80; Aspergillus ustus; Biosynthesis; Cytochrome; Cytochrome P450; Cytochromes P450; Enzymes; Epimerase; Fungi; Gene deletion; Gene expression; Humanities and Social Sciences; Hydroxyl groups; Hydroxylation; Methylation; multidisciplinary; Natural products; Peptide synthase; Quinazolinone; Rings (mathematics); Science; Science (multidisciplinary)

Oxepinamides are derivatives of anthranilyl-containing tripeptides and share an oxepin ring and a fused pyrimidinone moiety. To the best of our knowledge, no studies have been reported on the elucidation of an oxepinamide biosynthetic pathway and conversion of a quinazolinone to a pyrimidinone-fused...