Large-Scale Isolation of Human Hepatocytes for Therapeutic Application

• Published in: Cell transplantation Vol. 14; no. 10; pp. 845 - 853
• Main Authors: Alexandrova, Krassimira, Griesel, Carsten, Barthold, Marc, Heuft, Hans-Gert, Ott, Michael, Winkler, Michael, Schrem, Harald, Manns, Michael P., Bredehornsp, Timm, Net, Marc, Vidal, Martí Manyalich I, Kafert-Kasting, Sabine, Arseniev, Lubomir
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.11.2005; SAGE Publishing
• Subjects: Adult; Aged; Cell Count; Cell Separation - methods; Cell Separation - standards; Cell Survival; Cell Transplantation - methods; Cell Transplantation - standards; Cells, Cultured; Cryopreservation - methods; Fatty Liver - surgery; Female; Guidelines as Topic; Hepatocytes - cytology; Hepatocytes - transplantation; Humans; Male; Middle Aged; Quality Control; Tissue and Organ Procurement - methods; Tissue Donors; GMP; Hepatocyte isolation; Cell transplantation; Steatosis

During the last decade, hepatocyte transplantation has been suggested as a safe and potentially effective clinical option for the treatment of acute or decompensating chronic liver failure as well as for hereditary liver disease. Currently, one of the major limiting factors for clinical application...