Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis

• Published in: Nature communications Vol. 12; no. 1; pp. 4977 - 15
• Main Authors: Wu, Xunyao, Liu, Yi, Jin, Shanzhao, Wang, Min, Jiao, Yuhao, Yang, Bo, Lu, Xin, Ji, Xin, Fei, Yunyun, Yang, Huaxia, Zhao, Lidan, Chen, Hua, Zhang, Yaran, Li, Hao, Lipsky, Peter E., Tsokos, George C., Bai, Fan, Zhang, Xuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.08.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/51; 38/23; 38/91; 631/250/38; 692/699/1670/498; Abnormalities; Antibodies; Arthritis; Autoimmune diseases; Blood; CCL18 protein; CD45 antigen; Citrulline; Cytotoxicity; Drb1 protein; Gene sequencing; Haplotypes; Heterogeneity; Histocompatibility antigen HLA; Humanities and Social Sciences; Immune system; multidisciplinary; Pathogenesis; Patients; Peptides; Peripheral blood; Rheumatoid arthritis; Ribonucleic acid; RNA; Science; Science (multidisciplinary); Serology

The presence or absence of anti-citrullinated peptide antibodies (ACPA) and associated disparities in patients with rheumatoid arthritis (RA) implies disease heterogeneity with unknown diverse immunopathological mechanisms. Here we profile CD45 + hematopoietic cells from peripheral blood or synovial...