Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system

CYP24A1-deficient (Cyp24a1 KO) rats were generated using the CRISPER/Cas9 system to investigate CYP24A1-dependent or -independent metabolism of 25(OH)D3, the prohormone of calcitriol. Plasma 25(OH)D3 concentrations in Cyp24a1 KO rats were approximately twofold higher than in wild-type rats. Wild-typ...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of biological chemistry Vol. 296; p. 100668
Main Authors Yasuda, Kaori, Nishikawa, Miyu, Okamoto, Kairi, Horibe, Kyohei, Mano, Hiroki, Yamaguchi, Mana, Okon, Risa, Nakagawa, Kimie, Tsugawa, Naoko, Okano, Toshio, Kawagoe, Fumihiro, Kittaka, Atsushi, Ikushiro, Shinichi, Sakaki, Toshiyuki
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2021
American Society for Biochemistry and Molecular Biology
Subjects
CRISPR/Cas9
CYP24A1
cytochrome P450
metabolism
vitamin D
CYP24A1
CRISPR/Cas9
ADX
PTH
VDR
vitamin D
1,25(OH)2D3
metabolism
cytochrome P450
25(OH)D3
ADR
Online AccessGet full text

Cover

Abstract CYP24A1-deficient (Cyp24a1 KO) rats were generated using the CRISPER/Cas9 system to investigate CYP24A1-dependent or -independent metabolism of 25(OH)D3, the prohormone of calcitriol. Plasma 25(OH)D3 concentrations in Cyp24a1 KO rats were approximately twofold higher than in wild-type rats. Wild-type rats showed five metabolites of 25(OH)D3 in plasma following oral administration of 25(OH)D3, and these metabolites were not detected in Cyp24a1 KO rats. Among these metabolites, 25(OH)D3-26,23-lactone was identified as the second major metabolite with a significantly higher Tmax value than others. When 23S,25(OH)2D3 was administered to Cyp24a1 KO rats, neither 23,25,26(OH)3D3 nor 25(OH)D3-26,23-lactone was observed. However, when 23S,25R,26(OH)3D3 was administered to Cyp24a1 KO rats, plasma 25(OH)D3-26,23-lactone was detected. These results suggested that CYP24A1 is responsible for the conversion of 25(OH)D3 to 23,25,26(OH)3D3 via 23,25(OH)2D3, but enzyme(s) other than CYP24A1 may be involved in the conversion of 23,25,26(OH)3D3 to 25(OH)D3-26,23-lactone. Enzymatic studies using recombinant human CYP species and the inhibitory effects of ketoconazole suggested that CYP3A plays an essential role in the conversion of 23,25,26(OH)3D3 into 25(OH)D3-26,23-lactone in both rats and humans. Taken together, our data indicate that Cyp24a1 KO rats are valuable for metabolic studies of vitamin D and its analogs. In addition, long-term administration of 25(OH)D3 to Cyp24a1 KO rats at 110 μg/kg body weight/day resulted in significant weight loss and ectopic calcification. Thus, Cyp24a1 KO rats could represent an important model for studying renal diseases originating from CYP24A1 dysfunction.
AbstractList CYP24A1-deficient (Cyp24a1 KO) rats were generated using the CRISPER/Cas9 system to investigate CYP24A1-dependent or -independent metabolism of 25(OH)D3, the prohormone of calcitriol. Plasma 25(OH)D3 concentrations in Cyp24a1 KO rats were approximately twofold higher than in wild-type rats. Wild-type rats showed five metabolites of 25(OH)D3 in plasma following oral administration of 25(OH)D3, and these metabolites were not detected in Cyp24a1 KO rats. Among these metabolites, 25(OH)D3-26,23-lactone was identified as the second major metabolite with a significantly higher Tmax value than others. When 23S,25(OH)2D3 was administered to Cyp24a1 KO rats, neither 23,25,26(OH)3D3 nor 25(OH)D3-26,23-lactone was observed. However, when 23S,25R,26(OH)3D3 was administered to Cyp24a1 KO rats, plasma 25(OH)D3-26,23-lactone was detected. These results suggested that CYP24A1 is responsible for the conversion of 25(OH)D3 to 23,25,26(OH)3D3 via 23,25(OH)2D3, but enzyme(s) other than CYP24A1 may be involved in the conversion of 23,25,26(OH)3D3 to 25(OH)D3-26,23-lactone. Enzymatic studies using recombinant human CYP species and the inhibitory effects of ketoconazole suggested that CYP3A plays an essential role in the conversion of 23,25,26(OH)3D3 into 25(OH)D3-26,23-lactone in both rats and humans. Taken together, our data indicate that Cyp24a1 KO rats are valuable for metabolic studies of vitamin D and its analogs. In addition, long-term administration of 25(OH)D3 to Cyp24a1 KO rats at 110 μg/kg body weight/day resulted in significant weight loss and ectopic calcification. Thus, Cyp24a1 KO rats could represent an important model for studying renal diseases originating from CYP24A1 dysfunction.
CYP24A1-deficient (Cyp24a1 KO) rats were generated using the CRISPER/Cas9 system to investigate CYP24A1-dependent or -independent metabolism of 25(OH)D3, the prohormone of calcitriol. Plasma 25(OH)D3 concentrations in Cyp24a1 KO rats were approximately two-fold higher than in wild-type rats. Wild-type rats showed five metabolites of 25(OH)D3 in plasma following oral administration of 25(OH)D3, and these metabolites were not detected in Cyp24a1 KO rats. Among these metabolites, 25(OH)D3-26,23-lactone was identified as the second major metabolite with a significantly higher T value than others. When 23S,25(OH) D3 was administered to Cyp24a1 KO rats, neither 23,25,26(OH) D3 nor 25(OH)D3-26,23-lactone were observed. However, when 23S,25R,26(OH) D3 was administered to Cyp24a1 KO rats, plasma 25(OH)D3-26,23-lactone was detected. These results suggested that CYP24A1 is responsible for the conversion of 25(OH)D3 to 23,25,26(OH) D3 via 23,25(OH) D3, but enzyme(s) other than CYP24A1 may be involved in the conversion of 23,25,26(OH) D3 to 25(OH)D3-26,23-lactone. Enzymatic studies using recombinant human CYP species and the inhibitory effects of ketoconazole suggested that CYP3A plays an essential role in the conversion of 23,25,26(OH) D3 into 25(OH)D3-26,23-lactone in both rats and humans. Taken together, our data indicate that Cyp24a1 KO rats are valuable for metabolic studies of vitamin D and its analogs. In addition, long-term administration of 25(OH)D3 to Cyp24a1 KO rats at 110 μg/kg body weight/day resulted in significant weight loss and ectopic calcification. Thus, Cyp24a1 KO rats could represent an important model for studying renal diseases originating from CYP24A1 dysfunction.
CYP24A1-deficient ( Cyp24a1 KO) rats were generated using the CRISPER/Cas9 system to investigate CYP24A1-dependent or -independent metabolism of 25(OH)D3, the prohormone of calcitriol. Plasma 25(OH)D3 concentrations in Cyp24a1 KO rats were approximately twofold higher than in wild-type rats. Wild-type rats showed five metabolites of 25(OH)D3 in plasma following oral administration of 25(OH)D3, and these metabolites were not detected in Cyp24a1 KO rats. Among these metabolites, 25(OH)D3-26,23-lactone was identified as the second major metabolite with a significantly higher T max value than others. When 23 S ,25(OH) 2 D3 was administered to Cyp24a1 KO rats, neither 23,25,26(OH) 3 D3 nor 25(OH)D3-26,23-lactone was observed. However, when 23 S ,25 R ,26(OH) 3 D3 was administered to Cyp24a1 KO rats, plasma 25(OH)D3-26,23-lactone was detected. These results suggested that CYP24A1 is responsible for the conversion of 25(OH)D3 to 23,25,26(OH) 3 D3 via 23,25(OH) 2 D3, but enzyme(s) other than CYP24A1 may be involved in the conversion of 23,25,26(OH) 3 D3 to 25(OH)D3-26,23-lactone. Enzymatic studies using recombinant human CYP species and the inhibitory effects of ketoconazole suggested that CYP3A plays an essential role in the conversion of 23,25,26(OH) 3 D3 into 25(OH)D3-26,23-lactone in both rats and humans. Taken together, our data indicate that Cyp24a1 KO rats are valuable for metabolic studies of vitamin D and its analogs. In addition, long-term administration of 25(OH)D3 to Cyp24a1 KO rats at 110 μg/kg body weight/day resulted in significant weight loss and ectopic calcification. Thus, Cyp24a1 KO rats could represent an important model for studying renal diseases originating from CYP24A1 dysfunction.
ArticleNumber 100668
Author Tsugawa, Naoko
Kawagoe, Fumihiro
Mano, Hiroki
Okano, Toshio
Yasuda, Kaori
Okon, Risa
Okamoto, Kairi
Horibe, Kyohei
Sakaki, Toshiyuki
Nishikawa, Miyu
Yamaguchi, Mana
Ikushiro, Shinichi
Nakagawa, Kimie
Kittaka, Atsushi
Author_xml – sequence: 1
  givenname: Kaori
  orcidid: 0000-0003-3495-3216
  surname: Yasuda
  fullname: Yasuda, Kaori
  organization: Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan
– sequence: 2
  givenname: Miyu
  surname: Nishikawa
  fullname: Nishikawa, Miyu
  organization: Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan
– sequence: 3
  givenname: Kairi
  surname: Okamoto
  fullname: Okamoto, Kairi
  organization: Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan
– sequence: 4
  givenname: Kyohei
  surname: Horibe
  fullname: Horibe, Kyohei
  organization: Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan
– sequence: 5
  givenname: Hiroki
  surname: Mano
  fullname: Mano, Hiroki
  organization: Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan
– sequence: 6
  givenname: Mana
  surname: Yamaguchi
  fullname: Yamaguchi, Mana
  organization: Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan
– sequence: 7
  givenname: Risa
  surname: Okon
  fullname: Okon, Risa
  organization: Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan
– sequence: 8
  givenname: Kimie
  surname: Nakagawa
  fullname: Nakagawa, Kimie
  organization: Laboratory of Hygienic Sciences, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Chuo-ku, Kobe, Japan
– sequence: 9
  givenname: Naoko
  surname: Tsugawa
  fullname: Tsugawa, Naoko
  organization: Department of Health and Nutrition, Faculty of Health and Nutrition, Osaka Shoin Women's University, Higashi-Osaka, Japan
– sequence: 10
  givenname: Toshio
  surname: Okano
  fullname: Okano, Toshio
  organization: Department of Hygienic Sciences, Kobe Pharmaceutical University, Higashinada-ku, Kobe, Japan
– sequence: 11
  givenname: Fumihiro
  surname: Kawagoe
  fullname: Kawagoe, Fumihiro
  organization: Faculty of Pharmaceutical Sciences, Teikyo University, Tokyo, Japan
– sequence: 12
  givenname: Atsushi
  surname: Kittaka
  fullname: Kittaka, Atsushi
  organization: Faculty of Pharmaceutical Sciences, Teikyo University, Tokyo, Japan
– sequence: 13
  givenname: Shinichi
  surname: Ikushiro
  fullname: Ikushiro, Shinichi
  organization: Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan
– sequence: 14
  givenname: Toshiyuki
  surname: Sakaki
  fullname: Sakaki, Toshiyuki
  email: tsakaki@pu-toyama.ac.jp
  organization: Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33865853$$D View this record in MEDLINE/PubMed
BookMark eNp9kctuEzEUhi1URNPCA7BBXrKZ1JfxXISEFA2lVKpEVUCCleXxnEmcTuzU9gTmOfrCOEqJYIM39vH5_9-X7wydWGcBodeUzCmhxcV6vm71nBFGU02KonqGZpRUPOOCfj9BM5I6Wc1EdYrOQliTNPKavkCnnFeFqASfocfLYdSmU9E4i12PNxBV6waj8VbF1U81hf0uE9lq6rz7Ne1MVBtj8QeepJ1RETrcTrj5ccvyBcXKdvs1X-AxGLvEzbRluaL43jp978aIvYoBL8GCP1rvrr_c3l00KtQ4TCHC5iV63qshwKun-Rx9-3j5tfmU3Xy-um4WN5kWtIwZAOM5qEJrEAp0yVnbFq2mmvG2K1sNPa2LShBRqZ7nWhelFj3LK9rlpSaV4ufo_SF3O7bpMRps9GqQW282yk_SKSP_7Vizkku3kxXlOSlZCnj7FODdwwghyo0JGoZBWXBjkExQQYq8qEmS0oNUexeCh_54DCVyD1OuZYIp9zDlAWbyvPn7fkfHH3pJ8O4ggPRLOwNeBm3A6gTGg46yc-Y_8b8ByR2ykA
CitedBy_id crossref_primary_10_3390_molecules27165352
crossref_primary_10_1248_cpb_c23_00395
crossref_primary_10_3390_ijms22158191
crossref_primary_10_3390_biom14060717
crossref_primary_10_3390_biom11111639
crossref_primary_10_1371_journal_ppat_1009986
crossref_primary_10_3390_ijms222111863
crossref_primary_10_1007_s00795_024_00387_y
crossref_primary_10_1016_j_bcp_2024_116231
crossref_primary_10_1021_acs_joc_3c01134
crossref_primary_10_3390_ijms23052548
crossref_primary_10_3390_biom14010037
crossref_primary_10_17816_clinutr115028
crossref_primary_10_3390_ijms222111839
crossref_primary_10_7554_eLife_75419
Cites_doi 10.1016/0014-5793(82)80867-3
10.1016/S8756-3282(99)00118-0
10.1210/endo.141.7.7579
10.1016/j.abb.2011.11.003
10.1016/0022-4731(86)90395-X
10.1016/j.jsbmb.2018.07.012
10.1111/febs.12862
10.1073/pnas.0702093104
10.1016/0014-5793(81)80603-5
10.1007/s13353-017-0397-2
10.1046/j.1432-1327.2000.01680.x
10.1248/bpb.28.646
10.2215/CJN.05360512
10.1056/NEJMoa1103864
10.1016/j.jsbmb.2018.02.001
10.1042/bj2500527
10.1016/S0076-6879(05)00010-8
10.1248/bpb.24.738
10.1016/j.jsbmb.2018.10.010
10.1016/S0021-9258(18)34119-X
10.1172/JCI98680
10.1210/en.2004-1116
10.1210/en.2015-1664
10.1210/jc.2013-4388
10.1016/j.apsb.2019.03.005
10.1073/pnas.77.11.6411
10.1038/s41598-020-62048-1
10.1016/j.jsbmb.2018.12.001
10.1124/dmd.117.078428
10.1210/en.2013-2013
10.1016/S0021-9258(18)48219-1
10.1002/jbmr.3135
10.1016/j.bbrc.2004.07.040
ContentType Journal Article
Copyright 2021 The Authors
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
2021 The Authors 2021
Copyright_xml – notice: 2021 The Authors
– notice: Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
– notice: 2021 The Authors 2021
DBID 6I.
AAFTH
NPM
AAYXX
CITATION
7X8
5PM
DOI 10.1016/j.jbc.2021.100668
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList
PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Chemistry
EISSN 1083-351X
EndPage 100668
ExternalDocumentID 10_1016_j_jbc_2021_100668
33865853
S0021925821004579
Genre Journal Article
GroupedDBID ---
-DZ
-ET
-~X
.55
.GJ
0SF
186
18M
29J
2WC
34G
39C
3O-
4.4
41~
53G
5BI
5GY
5RE
5VS
6I.
6TJ
79B
85S
AAEDW
AAFTH
AAFWJ
AARDX
AAXUO
AAYJJ
AAYOK
ABDNZ
ABFSI
ABOCM
ABPPZ
ABRJW
ABTAH
ACGFO
ACNCT
ACSFO
ACYGS
ADBBV
ADIYS
ADNWM
AENEX
AEXQZ
AFDAS
AFFNX
AFMIJ
AFOSN
AFPKN
AHPSJ
AI.
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
AOIJS
BAWUL
BTFSW
C1A
CJ0
CS3
DIK
DU5
E.L
E3Z
EBS
EJD
F20
F5P
FA8
FDB
FRP
GROUPED_DOAJ
GX1
HH5
HYE
IH2
J5H
KQ8
L7B
MVM
N9A
NHB
OHT
OK1
P-O
P0W
P2P
QZG
R.V
RHF
RHI
RNS
ROL
RPM
SJN
TBC
TN5
TR2
UHB
UKR
UPT
UQL
VH1
VQA
W8F
WH7
WHG
WOQ
X7M
XFK
XJT
XSW
Y6R
YQT
YSK
YWH
YYP
YZZ
ZA5
ZE2
ZGI
ZY4
~02
~KM
0R~
AALRI
ADVLN
AITUG
AKRWK
NPM
AAYXX
CITATION
H13
7X8
5PM
ID FETCH-LOGICAL-c517t-ee234ea6cce5aec732bb6bc1c23bd7bcef19685058af34cc67c5f2481d47c08a3
IEDL.DBID RPM
ISSN 0021-9258
IngestDate Tue Sep 17 21:17:12 EDT 2024
Fri Oct 25 03:19:12 EDT 2024
Fri Aug 23 04:02:27 EDT 2024
Sat Sep 28 08:28:53 EDT 2024
Fri Feb 23 02:43:02 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords CYP24A1
CRISPR/Cas9
ADX
PTH
VDR
vitamin D
1,25(OH)2D3
metabolism
cytochrome P450
25(OH)D3
ADR
Language English
License This is an open access article under the CC BY license.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c517t-ee234ea6cce5aec732bb6bc1c23bd7bcef19685058af34cc67c5f2481d47c08a3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-3495-3216
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134072/
PMID 33865853
PQID 2515064690
PQPubID 23479
PageCount 1
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8134072
proquest_miscellaneous_2515064690
crossref_primary_10_1016_j_jbc_2021_100668
pubmed_primary_33865853
elsevier_sciencedirect_doi_10_1016_j_jbc_2021_100668
PublicationCentury 2000
PublicationDate 2021-01-01
PublicationDateYYYYMMDD 2021-01-01
PublicationDate_xml – month: 01
  year: 2021
  text: 2021-01-01
  day: 01
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle The Journal of biological chemistry
PublicationTitleAlternate J Biol Chem
PublicationYear 2021
Publisher Elsevier Inc
American Society for Biochemistry and Molecular Biology
Publisher_xml – name: Elsevier Inc
– name: American Society for Biochemistry and Molecular Biology
References Bouillon, Okamura, Norman (bib22) 1995; 16
Masuda, Byford, Arabian, Sakai, Demay, St-Arnaud, Jones (bib12) 2005; 146
Kaufmann, Gallagher, Peacock, Schlingmann, Konrad, DeLuca, Sigueiro, Lopez, Mourino, Maestro, St-Arnaud, Finkelstein, Cooper, Jones (bib16) 2014; 99
Kaufmann, Morse, Molloy, Cooper, Schlingmann, Molin, Kottler, Gallagher, Armas, Jones (bib15) 2017; 32
Kusudo, Sakaki, Abe, Fujishima, Kittaka, Takayama, Hatakeyama, Ohta, Inouye (bib6) 2004; 321
Ishizuka, Yamaguchi, Yamada, Nakayama, Takayama (bib19) 1981; 134
Kawagoe, Sugiyama, Yasuda, Uesugi, Sakaki, Kittaka (bib33) 2019; 186
Higashi, Awada, Shimada (bib20) 2001; 24
Chatterjee, Echchgadda, Song (bib30) 2005; 400
Tieu, Tang, Tuckey (bib35) 2014; 281
Pedersen, Hagenfeldt, Bjorkhem (bib7) 1988; 250
Yasuda, Tohyama, Takano, Kittaka, Ohta, Ikushiro, Sakaki (bib34) 2018; 178
Jones, Prosser, Kaufmann (bib1) 2012; 523
Nishikawa, Yasuda, Takamatsu, Abe, Okamoto, Horibe, Mano, Nakagawa, Tsugawa, Hirota, Horie, Hinoi, Okano, Ikushiro, Sakaki (bib17) 2020; 10
Prosser, Kaufmann, O'Leary, Byford, Jones (bib8) 2007; 104
Nishikawa, Yasuda, Takamatsu, Abe, Nakagawa, Tsugawa, Hirota, Tanaka, Yamashita, Ikushiro, Suda, Okano, Sakaki (bib11) 2019; 185
Kaufmann, Lee, Pike, Jones (bib14) 2015; 156
St-Arnaud (bib21) 1999; 25
Ishizuka, Norman (bib23) 1987; 262
Kaufmann, Martineau, Arabian, Traynor, St-Arnaud, Jones (bib13) 2019; 188
St-Arnaud, Arabian, Travers, Barletta, Raval-Pandya, Chapin, Depovere, Mathieu, Christakos, Demay, Glorieux (bib32) 2000; 141
Schlingmann, Kaufmann, Weber, Irwin, Goos, John, Misselwitz, Klaus, Kuwertz-Broking, Fehrenbach, Wingen, Guran, Hoenderop, Bindels, Prosser (bib4) 2011; 365
Ishizuka, Norman (bib26) 1986; 25
Sakaki, Sawada, Komai, Shiozawa, Yamada, Yamamoto, Ohyama, Inouye (bib5) 2000; 267
Qin, Wang (bib29) 2019; 9
Napoli, Pramanik, Partridge, Uskokovic, Horst (bib9) 1982; 257
Pronicka, Ciara, Halat, Janiec, Wojcik, Rowinska, Rokicki, Pludowski, Wojciechowska, Wierzbicka, Ksiazyk, Jacoszek, Konrad, Schlingmann, Litwin (bib31) 2017; 58
Ishizuka, Ishimoto, Norman (bib18) 1982; 139
Matsunaga, Higuchi, Watanabe, Kageyama, Ohmori, Yamamoto (bib24) 2005; 28
Wong, Wang, Chapron, Suzuki, Claw, Gao, Foti, Prasad, Chapron, Calamia, Chaudhry, Schuetz, Horst, Mao, de Boer (bib27) 2018; 46
Wang, Wong, Hashizume, Dickmann, Scian, Koszewski, Goff, Horst, Chaudhry, Schuetz, Thummel (bib28) 2014; 155
Sakaki, Kagawa, Yamamoto, Inouye (bib2) 2005; 10
Roizen, Li, O'Lear, Javaid, Shaw, Ebeling, Nguyen, Rodda, Thummel, Thacher, Hakonarson, Levine (bib25) 2018; 128
Tanaka, Wichmann, Paaren, Schnoes, DeLuca (bib10) 1980; 77
Nesterova, Malicdan, Yasuda, Sakaki, Vilboux, Ciccone, Horst, Huang, Golas, Introne, Huizing, Adams, Boerkoel, Collins, Gahl (bib3) 2013; 8
Chatterjee (10.1016/j.jbc.2021.100668_bib30) 2005; 400
Masuda (10.1016/j.jbc.2021.100668_bib12) 2005; 146
Kusudo (10.1016/j.jbc.2021.100668_bib6) 2004; 321
Kaufmann (10.1016/j.jbc.2021.100668_bib14) 2015; 156
Tanaka (10.1016/j.jbc.2021.100668_bib10) 1980; 77
Nishikawa (10.1016/j.jbc.2021.100668_bib17) 2020; 10
Ishizuka (10.1016/j.jbc.2021.100668_bib23) 1987; 262
Higashi (10.1016/j.jbc.2021.100668_bib20) 2001; 24
Kaufmann (10.1016/j.jbc.2021.100668_bib13) 2019; 188
Sakaki (10.1016/j.jbc.2021.100668_bib5) 2000; 267
Pedersen (10.1016/j.jbc.2021.100668_bib7) 1988; 250
Nesterova (10.1016/j.jbc.2021.100668_bib3) 2013; 8
Wang (10.1016/j.jbc.2021.100668_bib28) 2014; 155
Prosser (10.1016/j.jbc.2021.100668_bib8) 2007; 104
Kaufmann (10.1016/j.jbc.2021.100668_bib16) 2014; 99
Sakaki (10.1016/j.jbc.2021.100668_bib2) 2005; 10
Bouillon (10.1016/j.jbc.2021.100668_bib22) 1995; 16
Matsunaga (10.1016/j.jbc.2021.100668_bib24) 2005; 28
Roizen (10.1016/j.jbc.2021.100668_bib25) 2018; 128
Qin (10.1016/j.jbc.2021.100668_bib29) 2019; 9
Kaufmann (10.1016/j.jbc.2021.100668_bib15) 2017; 32
Wong (10.1016/j.jbc.2021.100668_bib27) 2018; 46
St-Arnaud (10.1016/j.jbc.2021.100668_bib32) 2000; 141
Schlingmann (10.1016/j.jbc.2021.100668_bib4) 2011; 365
Napoli (10.1016/j.jbc.2021.100668_bib9) 1982; 257
Nishikawa (10.1016/j.jbc.2021.100668_bib11) 2019; 185
Yasuda (10.1016/j.jbc.2021.100668_bib34) 2018; 178
Tieu (10.1016/j.jbc.2021.100668_bib35) 2014; 281
Kawagoe (10.1016/j.jbc.2021.100668_bib33) 2019; 186
Ishizuka (10.1016/j.jbc.2021.100668_bib18) 1982; 139
Pronicka (10.1016/j.jbc.2021.100668_bib31) 2017; 58
Jones (10.1016/j.jbc.2021.100668_bib1) 2012; 523
Ishizuka (10.1016/j.jbc.2021.100668_bib19) 1981; 134
St-Arnaud (10.1016/j.jbc.2021.100668_bib21) 1999; 25
Ishizuka (10.1016/j.jbc.2021.100668_bib26) 1986; 25
References_xml – volume: 28
  start-page: 646
  year: 2005
  end-page: 651
  ident: bib24
  article-title: Effective NADH-dependent oxidation of 7beta-hydroxy-delta8-tetrahydrocannabinol to the corresponding ketone by Japanese monkey hepatic microsomes
  publication-title: Biol. Pharm. Bull.
  contributor:
    fullname: Yamamoto
– volume: 257
  start-page: 9634
  year: 1982
  end-page: 9639
  ident: bib9
  article-title: 23S,25-dihydroxyvitamin D3 as a circulating metabolite of vitamin D3. Its role in 25-hydroxyvitamin D3-26,23-lactone biosynthesis
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Horst
– volume: 99
  start-page: 2567
  year: 2014
  end-page: 2574
  ident: bib16
  article-title: Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D by LC-MS/MS involving derivatization with DMEQ-TAD
  publication-title: J. Clin. Endocrinol. Metab.
  contributor:
    fullname: Jones
– volume: 156
  start-page: 4388
  year: 2015
  end-page: 4397
  ident: bib14
  article-title: A high-calcium and phosphate rescue diet and VDR-expressing transgenes normalize serum vitamin D metabolite profiles and renal Cyp27b1 and Cyp24a1 expression in VDR null mice
  publication-title: Endocrinology
  contributor:
    fullname: Jones
– volume: 32
  start-page: 1589
  year: 2017
  end-page: 1596
  ident: bib15
  article-title: Improved screening test for idiopathic infantile hypercalcemia confirms residual levels of serum 24,25-(OH)2 D3 in affected patients
  publication-title: J. Bone Miner. Res.
  contributor:
    fullname: Jones
– volume: 46
  start-page: 367
  year: 2018
  end-page: 379
  ident: bib27
  article-title: Polymorphic human sulfotransferase 2A1 mediates the formation of 25-hydroxyvitamin D3-3-O-sulfate, a major circulating vitamin D metabolite in humans
  publication-title: Drug Metab. Dispos.
  contributor:
    fullname: de Boer
– volume: 185
  start-page: 71
  year: 2019
  end-page: 79
  ident: bib11
  article-title: Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes
  publication-title: J. Steroid Biochem. Mol. Biol.
  contributor:
    fullname: Sakaki
– volume: 10
  start-page: 5677
  year: 2020
  ident: bib17
  article-title: Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions
  publication-title: Sci. Rep.
  contributor:
    fullname: Sakaki
– volume: 188
  start-page: 23
  year: 2019
  end-page: 28
  ident: bib13
  article-title: Calcioic acid:
  publication-title: J. Steroid Biochem. Mol. Biol.
  contributor:
    fullname: Jones
– volume: 25
  start-page: 505
  year: 1986
  end-page: 510
  ident: bib26
  article-title: The difference of biological activity among four diastereoisomers of 1α,25-dihydroxycholecalciferol-26,23-lactone
  publication-title: J. Steroid Biochem.
  contributor:
    fullname: Norman
– volume: 10
  start-page: 119
  year: 2005
  end-page: 134
  ident: bib2
  article-title: Metabolism of vitamin D3 by cytochromes P450
  publication-title: Front. Biosci.
  contributor:
    fullname: Inouye
– volume: 141
  start-page: 2658
  year: 2000
  end-page: 2666
  ident: bib32
  article-title: Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D
  publication-title: Endocrinology
  contributor:
    fullname: Glorieux
– volume: 267
  start-page: 6158
  year: 2000
  end-page: 6165
  ident: bib5
  article-title: Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24
  publication-title: Eur. J. Biochem.
  contributor:
    fullname: Inouye
– volume: 281
  start-page: 3280
  year: 2014
  end-page: 3296
  ident: bib35
  article-title: Kinetic analysis of human CYP24A1 metabolism of vitamin D via the C24-oxidation pathway
  publication-title: FEBS J.
  contributor:
    fullname: Tuckey
– volume: 155
  start-page: 2052
  year: 2014
  end-page: 2063
  ident: bib28
  article-title: Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: Metabolite structure, kinetics, inducibility, and interindividual variability
  publication-title: Endocrinology
  contributor:
    fullname: Thummel
– volume: 16
  start-page: 200
  year: 1995
  end-page: 257
  ident: bib22
  article-title: Structure-function relationships in the vitamin D endocrine system
  publication-title: Endocr. Rev.
  contributor:
    fullname: Norman
– volume: 321
  start-page: 774
  year: 2004
  end-page: 782
  ident: bib6
  article-title: Metabolism of A-ring diastereomers of 1α,25-dihydroxyvitamin D3 by CYP24A1
  publication-title: Biochem. Biophys. Res. Commun.
  contributor:
    fullname: Inouye
– volume: 186
  start-page: 161
  year: 2019
  end-page: 168
  ident: bib33
  article-title: Concise synthesis of 23-hydroxylated vitamin D3 metabolites
  publication-title: J. Steroid Biochem. Mol. Biol.
  contributor:
    fullname: Kittaka
– volume: 523
  start-page: 9
  year: 2012
  end-page: 18
  ident: bib1
  article-title: 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D
  publication-title: Arch. Biochem. Biophys.
  contributor:
    fullname: Kaufmann
– volume: 25
  start-page: 127
  year: 1999
  end-page: 129
  ident: bib21
  article-title: Targeted inactivation of vitamin D hydroxylases in mice
  publication-title: Bone
  contributor:
    fullname: St-Arnaud
– volume: 365
  start-page: 410
  year: 2011
  end-page: 421
  ident: bib4
  article-title: Mutations in CYP24A1 and idiopathic infantile hypercalcemia
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Prosser
– volume: 134
  start-page: 207
  year: 1981
  end-page: 211
  ident: bib19
  article-title: Stereochemistry of 25-hydroxyvitamin D3-26,23-lactone and 1α, 25-dihydroxyvitamin D3-26,23-lactone in rat serum
  publication-title: FEBS Lett.
  contributor:
    fullname: Takayama
– volume: 104
  start-page: 12673
  year: 2007
  end-page: 12678
  ident: bib8
  article-title: Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1α,25-(OH)2D3-26,23-lactone
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Jones
– volume: 8
  start-page: 649
  year: 2013
  end-page: 657
  ident: bib3
  article-title: 1,25-(OH)2D-24 hydroxylase (CYP24A1) deficiency as a cause of nephrolithiasis
  publication-title: Clin. J. Am. Soc. Nephrol.
  contributor:
    fullname: Gahl
– volume: 146
  start-page: 825
  year: 2005
  end-page: 834
  ident: bib12
  article-title: Altered pharmacokinetics of 1α,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse
  publication-title: Endocrinology
  contributor:
    fullname: Jones
– volume: 58
  start-page: 349
  year: 2017
  end-page: 353
  ident: bib31
  article-title: Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: Molecular study of 11 historical IIH cases
  publication-title: J. Appl. Genet.
  contributor:
    fullname: Litwin
– volume: 24
  start-page: 738
  year: 2001
  end-page: 743
  ident: bib20
  article-title: Simultaneous determination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in human plasma by liquid chromatography-tandem mass spectrometry employing derivatization with a Cookson-type reagent
  publication-title: Biol. Pharm. Bull.
  contributor:
    fullname: Shimada
– volume: 400
  start-page: 165
  year: 2005
  end-page: 191
  ident: bib30
  article-title: Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1
  publication-title: Methods Enzymol.
  contributor:
    fullname: Song
– volume: 250
  start-page: 527
  year: 1988
  end-page: 532
  ident: bib7
  article-title: Assay and properties of 25-hydroxyvitamin D3 23-hydroxylase. Evidence that 23,25-dihydroxyvitamin D3 is a major metabolite in 1,25-dihydroxyvitamin D3-treated or fasted Guinea pigs
  publication-title: Biochem. J.
  contributor:
    fullname: Bjorkhem
– volume: 139
  start-page: 267
  year: 1982
  end-page: 270
  ident: bib18
  article-title: Biological activity assessment of 25-hydroxyvitamin D3-26,23-lactone in the rat
  publication-title: FEBS Lett.
  contributor:
    fullname: Norman
– volume: 128
  start-page: 1913
  year: 2018
  end-page: 1918
  ident: bib25
  article-title: CYP3A4 mutation causes vitamin D-dependent rickets type 3
  publication-title: J. Clin. Invest.
  contributor:
    fullname: Levine
– volume: 9
  start-page: 1087
  year: 2019
  end-page: 1098
  ident: bib29
  article-title: Role of vitamin D receptor in the regulation of CYP3A gene expression
  publication-title: Acta Pharm. Sin. B
  contributor:
    fullname: Wang
– volume: 77
  start-page: 6411
  year: 1980
  end-page: 6414
  ident: bib10
  article-title: Role of kidney tissue in the production of 25-hydroxyvitamin D3-26,23-lactone and 1α,25-dihydroxyvitamin D3-26,23-lactone
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: DeLuca
– volume: 178
  start-page: 333
  year: 2018
  end-page: 339
  ident: bib34
  article-title: Metabolism of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D3 by CYP24A1 and biological activity of its 24
  publication-title: J. Steroid Biochem. Mol. Biol.
  contributor:
    fullname: Sakaki
– volume: 262
  start-page: 7165
  year: 1987
  end-page: 7170
  ident: bib23
  article-title: Metabolic pathways from 1α,25-dihydroxyvitamin D3 to 1α,25-dihydroxyvitamin D3-26,23-lactone. Stereo-retained and stereo-selective lactonization
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Norman
– volume: 139
  start-page: 267
  year: 1982
  ident: 10.1016/j.jbc.2021.100668_bib18
  article-title: Biological activity assessment of 25-hydroxyvitamin D3-26,23-lactone in the rat
  publication-title: FEBS Lett.
  doi: 10.1016/0014-5793(82)80867-3
  contributor:
    fullname: Ishizuka
– volume: 10
  start-page: 119
  year: 2005
  ident: 10.1016/j.jbc.2021.100668_bib2
  article-title: Metabolism of vitamin D3 by cytochromes P450
  publication-title: Front. Biosci.
  contributor:
    fullname: Sakaki
– volume: 25
  start-page: 127
  year: 1999
  ident: 10.1016/j.jbc.2021.100668_bib21
  article-title: Targeted inactivation of vitamin D hydroxylases in mice
  publication-title: Bone
  doi: 10.1016/S8756-3282(99)00118-0
  contributor:
    fullname: St-Arnaud
– volume: 141
  start-page: 2658
  year: 2000
  ident: 10.1016/j.jbc.2021.100668_bib32
  article-title: Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D
  publication-title: Endocrinology
  doi: 10.1210/endo.141.7.7579
  contributor:
    fullname: St-Arnaud
– volume: 523
  start-page: 9
  year: 2012
  ident: 10.1016/j.jbc.2021.100668_bib1
  article-title: 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1016/j.abb.2011.11.003
  contributor:
    fullname: Jones
– volume: 25
  start-page: 505
  year: 1986
  ident: 10.1016/j.jbc.2021.100668_bib26
  article-title: The difference of biological activity among four diastereoisomers of 1α,25-dihydroxycholecalciferol-26,23-lactone
  publication-title: J. Steroid Biochem.
  doi: 10.1016/0022-4731(86)90395-X
  contributor:
    fullname: Ishizuka
– volume: 185
  start-page: 71
  year: 2019
  ident: 10.1016/j.jbc.2021.100668_bib11
  article-title: Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes
  publication-title: J. Steroid Biochem. Mol. Biol.
  doi: 10.1016/j.jsbmb.2018.07.012
  contributor:
    fullname: Nishikawa
– volume: 281
  start-page: 3280
  year: 2014
  ident: 10.1016/j.jbc.2021.100668_bib35
  article-title: Kinetic analysis of human CYP24A1 metabolism of vitamin D via the C24-oxidation pathway
  publication-title: FEBS J.
  doi: 10.1111/febs.12862
  contributor:
    fullname: Tieu
– volume: 104
  start-page: 12673
  year: 2007
  ident: 10.1016/j.jbc.2021.100668_bib8
  article-title: Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1α,25-(OH)2D3-26,23-lactone
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0702093104
  contributor:
    fullname: Prosser
– volume: 134
  start-page: 207
  year: 1981
  ident: 10.1016/j.jbc.2021.100668_bib19
  article-title: Stereochemistry of 25-hydroxyvitamin D3-26,23-lactone and 1α, 25-dihydroxyvitamin D3-26,23-lactone in rat serum
  publication-title: FEBS Lett.
  doi: 10.1016/0014-5793(81)80603-5
  contributor:
    fullname: Ishizuka
– volume: 58
  start-page: 349
  year: 2017
  ident: 10.1016/j.jbc.2021.100668_bib31
  article-title: Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: Molecular study of 11 historical IIH cases
  publication-title: J. Appl. Genet.
  doi: 10.1007/s13353-017-0397-2
  contributor:
    fullname: Pronicka
– volume: 267
  start-page: 6158
  year: 2000
  ident: 10.1016/j.jbc.2021.100668_bib5
  article-title: Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24
  publication-title: Eur. J. Biochem.
  doi: 10.1046/j.1432-1327.2000.01680.x
  contributor:
    fullname: Sakaki
– volume: 28
  start-page: 646
  year: 2005
  ident: 10.1016/j.jbc.2021.100668_bib24
  article-title: Effective NADH-dependent oxidation of 7beta-hydroxy-delta8-tetrahydrocannabinol to the corresponding ketone by Japanese monkey hepatic microsomes
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.28.646
  contributor:
    fullname: Matsunaga
– volume: 8
  start-page: 649
  year: 2013
  ident: 10.1016/j.jbc.2021.100668_bib3
  article-title: 1,25-(OH)2D-24 hydroxylase (CYP24A1) deficiency as a cause of nephrolithiasis
  publication-title: Clin. J. Am. Soc. Nephrol.
  doi: 10.2215/CJN.05360512
  contributor:
    fullname: Nesterova
– volume: 365
  start-page: 410
  year: 2011
  ident: 10.1016/j.jbc.2021.100668_bib4
  article-title: Mutations in CYP24A1 and idiopathic infantile hypercalcemia
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1103864
  contributor:
    fullname: Schlingmann
– volume: 178
  start-page: 333
  year: 2018
  ident: 10.1016/j.jbc.2021.100668_bib34
  article-title: Metabolism of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D3 by CYP24A1 and biological activity of its 24R-hydroxylated metabolite
  publication-title: J. Steroid Biochem. Mol. Biol.
  doi: 10.1016/j.jsbmb.2018.02.001
  contributor:
    fullname: Yasuda
– volume: 250
  start-page: 527
  year: 1988
  ident: 10.1016/j.jbc.2021.100668_bib7
  article-title: Assay and properties of 25-hydroxyvitamin D3 23-hydroxylase. Evidence that 23,25-dihydroxyvitamin D3 is a major metabolite in 1,25-dihydroxyvitamin D3-treated or fasted Guinea pigs
  publication-title: Biochem. J.
  doi: 10.1042/bj2500527
  contributor:
    fullname: Pedersen
– volume: 400
  start-page: 165
  year: 2005
  ident: 10.1016/j.jbc.2021.100668_bib30
  article-title: Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(05)00010-8
  contributor:
    fullname: Chatterjee
– volume: 24
  start-page: 738
  year: 2001
  ident: 10.1016/j.jbc.2021.100668_bib20
  article-title: Simultaneous determination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in human plasma by liquid chromatography-tandem mass spectrometry employing derivatization with a Cookson-type reagent
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.24.738
  contributor:
    fullname: Higashi
– volume: 186
  start-page: 161
  year: 2019
  ident: 10.1016/j.jbc.2021.100668_bib33
  article-title: Concise synthesis of 23-hydroxylated vitamin D3 metabolites
  publication-title: J. Steroid Biochem. Mol. Biol.
  doi: 10.1016/j.jsbmb.2018.10.010
  contributor:
    fullname: Kawagoe
– volume: 257
  start-page: 9634
  year: 1982
  ident: 10.1016/j.jbc.2021.100668_bib9
  article-title: 23S,25-dihydroxyvitamin D3 as a circulating metabolite of vitamin D3. Its role in 25-hydroxyvitamin D3-26,23-lactone biosynthesis
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)34119-X
  contributor:
    fullname: Napoli
– volume: 128
  start-page: 1913
  year: 2018
  ident: 10.1016/j.jbc.2021.100668_bib25
  article-title: CYP3A4 mutation causes vitamin D-dependent rickets type 3
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI98680
  contributor:
    fullname: Roizen
– volume: 146
  start-page: 825
  year: 2005
  ident: 10.1016/j.jbc.2021.100668_bib12
  article-title: Altered pharmacokinetics of 1α,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse
  publication-title: Endocrinology
  doi: 10.1210/en.2004-1116
  contributor:
    fullname: Masuda
– volume: 156
  start-page: 4388
  year: 2015
  ident: 10.1016/j.jbc.2021.100668_bib14
  article-title: A high-calcium and phosphate rescue diet and VDR-expressing transgenes normalize serum vitamin D metabolite profiles and renal Cyp27b1 and Cyp24a1 expression in VDR null mice
  publication-title: Endocrinology
  doi: 10.1210/en.2015-1664
  contributor:
    fullname: Kaufmann
– volume: 99
  start-page: 2567
  year: 2014
  ident: 10.1016/j.jbc.2021.100668_bib16
  article-title: Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D by LC-MS/MS involving derivatization with DMEQ-TAD
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2013-4388
  contributor:
    fullname: Kaufmann
– volume: 9
  start-page: 1087
  year: 2019
  ident: 10.1016/j.jbc.2021.100668_bib29
  article-title: Role of vitamin D receptor in the regulation of CYP3A gene expression
  publication-title: Acta Pharm. Sin. B
  doi: 10.1016/j.apsb.2019.03.005
  contributor:
    fullname: Qin
– volume: 77
  start-page: 6411
  year: 1980
  ident: 10.1016/j.jbc.2021.100668_bib10
  article-title: Role of kidney tissue in the production of 25-hydroxyvitamin D3-26,23-lactone and 1α,25-dihydroxyvitamin D3-26,23-lactone
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.77.11.6411
  contributor:
    fullname: Tanaka
– volume: 10
  start-page: 5677
  year: 2020
  ident: 10.1016/j.jbc.2021.100668_bib17
  article-title: Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-62048-1
  contributor:
    fullname: Nishikawa
– volume: 188
  start-page: 23
  year: 2019
  ident: 10.1016/j.jbc.2021.100668_bib13
  article-title: Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3
  publication-title: J. Steroid Biochem. Mol. Biol.
  doi: 10.1016/j.jsbmb.2018.12.001
  contributor:
    fullname: Kaufmann
– volume: 46
  start-page: 367
  year: 2018
  ident: 10.1016/j.jbc.2021.100668_bib27
  article-title: Polymorphic human sulfotransferase 2A1 mediates the formation of 25-hydroxyvitamin D3-3-O-sulfate, a major circulating vitamin D metabolite in humans
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.117.078428
  contributor:
    fullname: Wong
– volume: 155
  start-page: 2052
  year: 2014
  ident: 10.1016/j.jbc.2021.100668_bib28
  article-title: Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: Metabolite structure, kinetics, inducibility, and interindividual variability
  publication-title: Endocrinology
  doi: 10.1210/en.2013-2013
  contributor:
    fullname: Wang
– volume: 262
  start-page: 7165
  year: 1987
  ident: 10.1016/j.jbc.2021.100668_bib23
  article-title: Metabolic pathways from 1α,25-dihydroxyvitamin D3 to 1α,25-dihydroxyvitamin D3-26,23-lactone. Stereo-retained and stereo-selective lactonization
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)48219-1
  contributor:
    fullname: Ishizuka
– volume: 32
  start-page: 1589
  year: 2017
  ident: 10.1016/j.jbc.2021.100668_bib15
  article-title: Improved screening test for idiopathic infantile hypercalcemia confirms residual levels of serum 24,25-(OH)2 D3 in affected patients
  publication-title: J. Bone Miner. Res.
  doi: 10.1002/jbmr.3135
  contributor:
    fullname: Kaufmann
– volume: 321
  start-page: 774
  year: 2004
  ident: 10.1016/j.jbc.2021.100668_bib6
  article-title: Metabolism of A-ring diastereomers of 1α,25-dihydroxyvitamin D3 by CYP24A1
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2004.07.040
  contributor:
    fullname: Kusudo
– volume: 16
  start-page: 200
  year: 1995
  ident: 10.1016/j.jbc.2021.100668_bib22
  article-title: Structure-function relationships in the vitamin D endocrine system
  publication-title: Endocr. Rev.
  contributor:
    fullname: Bouillon
SSID ssj0000491
Score 2.4688451
Snippet CYP24A1-deficient (Cyp24a1 KO) rats were generated using the CRISPER/Cas9 system to investigate CYP24A1-dependent or -independent metabolism of 25(OH)D3, the...
CYP24A1-deficient ( Cyp24a1 KO) rats were generated using the CRISPER/Cas9 system to investigate CYP24A1-dependent or -independent metabolism of 25(OH)D3, the...
SourceID pubmedcentral
proquest
crossref
pubmed
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 100668
SubjectTerms CRISPR/Cas9
CYP24A1
cytochrome P450
metabolism
vitamin D
Title Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system
URI https://dx.doi.org/10.1016/j.jbc.2021.100668
https://www.ncbi.nlm.nih.gov/pubmed/33865853
https://search.proquest.com/docview/2515064690
https://pubmed.ncbi.nlm.nih.gov/PMC8134072
Volume 296
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtQwFLXabmCDoOUxPCojIRZI6Uz8SrwchVYFVDQUKpVVZN84bcrEM2IyoHwHP4ztjCsKggWbKEpiydK59j2xj89F6EWuzCSTqnLMTULiMrRIpErrhPLKkQ3NtRD-gPPJe3F8xt6e8_MtxONZmCDaB90c2Hl7YJvLoK1ctjCOOrHx7KTIU-p9vcbbaNsFaPxFj9Mv25TJ89oDwvO4lRlEXVfa2xaS1IsDhPDF-qgveplz-re89Cfv_F0--Us-OrqL7myIJJ4OHb6HtozdRXtT636i2x6_xEHaGdbMd9GtIpZ120M_DudraIZKSnhR49Z0Lg7mDWBfnPi76lf-KeHJZV95icu3plNtY_FrisMpE8dQse5x8XlG2DTFylb-nk6xV9Bf4KJfEqZS_MW6iXax7rCLsBW-CObWsenpm4-z03GhVhIPRtL30dnR4afiONlUZkiAp1mXGEMoM0oAGK4MZJRoLTSkQKiuMg2mdgM7d-QqVzVlACIDXhPmuDHLYJIr-gDt2IU1jxBmUGUAmmRSOKZR1VrqWoJUmgOVFZARehVxKZeDAUcZlWlXpcOz9HiWA54jxCJy5YZBDMygdAniX82eR5RLh4bfMlHWLNar0rE_7-gn5GSEHg6oX_ciRs4IZTfi4foD79x9840L6ODgvQngx__d8gm67fs_rAU9RTvd17V55thRp_fDqoK7vvuQ74eR8ROVBBEd
link.rule.ids 230,315,730,783,787,867,888,27936,27937,53804,53806
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLXGeBgvCDZgHV9GQjwgZW38lfixCps6WKdqbNJ4iuwbZ8to0mpNQfkd_GHsJJ4YCB54i5JYcnSufY_j43MRehsrM4qkyixzkxDYDC0CqcI8oDyzZENzLYQ74Dw9EZNz9vGCX2wg7s_CtKJ90MV-NS_3q-Kq1VYuSxh6ndhwNk3ikDpfr-E9dN-O1xHzi3Q_AbO-UJ5THxAe-83MVtZ1rZ1xIQmdPEAIV66PurKXMad_y0x_Ms_fBZS_ZKTDR-hhTyXxuOvyY7Rhqm20M67sMrps8Dvcijvbv-bbaCvxhd120I-D-RqKrpYSXuS4NLWNhHkB2JUn_q6albtLeHDVZE7k8q2oVVlU-APF7TkTy1GxbnDyZUbYOMSqytw1HWOnob_ESbMkTIX4a2Wn2sW6xjbGVviytbf2TU-PPs9Oh4laSdxZST9B54cHZ8kk6GszBMDDqA6MIZQZJQAMVwYiSrQWGkIgVGeRBpPboR1behWrnDIAEQHPCbPsmEUwihV9ijarRWV2EWaQRQCaRFJYrpHlWupcglSaA5UZkAF673FJl50FR-q1adepxTN1eKYdngPEPHJpzyE6bpDaFPGvZm88yqlFw22aqMos1qvU8j_n6SfkaICedajf9sJHzgBFd-Lh9gXn3X33iQ3p1sO7D-G9_275Gm1NzqbH6fHRyafn6IH7lu7P0Au0Wd-szUvLlWr9qh0ZPwE8nhKJ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtQwFLWgSMAGQctjystIiAVSmolfiZejtKMWaDUqVCqryL5x2pRJZtTJgPId_DB2ElctCBbsoiSWHJ1r3-P4-FyE3ibKjGOpcsvcJAQ2Q4tAqqgIKM8t2dBcC-EOOB8eif0T9uGUn14r9dWJ9kGXO_W82qnL805buawg9DqxcHaYJhF1vl7hMi_C2-iOHbNj4RfqfhJmQ7E8p0AgPPEbmp2060I780ISOYmAEK5kH3WlLxNO_5ad_mSfv4sor2Wl6UP0YKCTeNJ3-xG6ZepNtDWp7VK6avE73Ak8uz_nm-he6ou7baGfe_M1lH09JbwocGUaGw3zErArUfxDtSt3l_DgvM2d0OV72aiqrPEuxd1ZE8tTsW5x-nVG2CTCqs7dNZ1gp6M_w2m7JExF-Fttp9vFusE2zlb4rLO49k2PDz7PjsNUrSTu7aQfo5Pp3pd0PxjqMwTAo7gJjCGUGSUADFcGYkq0FhoiIFTnsQZT2OGdWIqVqIIyABEDLwizDJnFME4UfYI26kVtniHMII8BNImlsHwjL7TUhQSpNAcqcyAj9N7jki17G47M69MuMotn5vDMejxHiHnksoFH9Pwgs2niX83eeJQzi4bbOFG1WaxXmeWAztdPyPEIPe1Rv-qFj5wRim_Ew9ULzr_75hMb1p2P9xDG2__d8jW6O9udZp8Ojj4-R_fdp_Q_h16gjeZybV5autToV93A-AUowROc
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Elucidation+of+metabolic+pathways+of+25-hydroxyvitamin+D3+mediated+by+CYP24A1+and+CYP3A+using+Cyp24a1+knockout+rats+generated+by+CRISPR%2FCas9+system&rft.jtitle=The+Journal+of+biological+chemistry&rft.au=Yasuda%2C+Kaori&rft.au=Nishikawa%2C+Miyu&rft.au=Okamoto%2C+Kairi&rft.au=Horibe%2C+Kyohei&rft.date=2021-01-01&rft.eissn=1083-351X&rft.volume=296&rft.spage=100668&rft.epage=100668&rft_id=info:doi/10.1016%2Fj.jbc.2021.100668&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9258&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9258&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9258&client=summon