Layer III pyramidal cells in the prefrontal cortex reveal morphological changes in subjects with depression, schizophrenia, and suicide

• Published in: Translational psychiatry Vol. 12; no. 1; pp. 363 - 11
• Main Authors: Larsen, Nick Y., Vihrs, Ninna, Møller, Jesper, Sporring, Jon, Tan, Xueke, Li, Xixia, Ji, Gang, Rajkowska, Grazyna, Sun, Fei, Nyengaard, Jens R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.09.2022; Nature Publishing Group
• Subjects: 13; 14; 14/63; 631/378/340; 706/648; Behavioral Sciences; Biological Psychology; Biophysics; Brain research; Clinical medicine; Medicine; Medicine & Public Health; Mental depression; Mental disorders; Microscopy; Morphology; Neural networks; Neurosciences; Pharmacotherapy; Psychiatrists; Psychiatry; Schizophrenia; Suicides & suicide attempts
• ISSN: 2158-3188; 2158-3188
• DOI: 10.1038/s41398-022-02128-0

Brodmann Area 46 (BA46) has long been regarded as a hotspot of disease pathology in individuals with schizophrenia (SCH) and major depressive disorder (MDD). Pyramidal neurons in layer III of the Brodmann Area 46 (BA46) project to other cortical regions and play a fundamental role in corticocortical...