Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5

• Published in: Nature communications Vol. 12; no. 1; pp. 5324 - 13
• Main Authors: Schroeder, Simon, Mache, Christin, Kleine-Weber, Hannah, Corman, Victor M., Muth, Doreen, Richter, Anja, Fatykhova, Diana, Memish, Ziad A., Stanifer, Megan L., Boulant, Steeve, Gultom, Mitra, Dijkman, Ronald, Eggeling, Stephan, Hocke, Andreas, Hippenstiel, Stefan, Thiel, Volker, Pöhlmann, Stefan, Wolff, Thorsten, Müller, Marcel A., Drosten, Christian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.09.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/596/2554; 631/326/596/2558; 631/326/596/2562; Camelidae; Camels; Camelus dromedarius; Clinical isolates; Contact potentials; Coronaviruses; Disease transmission; Fitness; Hospitals; Humanities and Social Sciences; Interferon; Middle East respiratory syndrome; multidisciplinary; Nosocomial infection; Pandemics; Replication; Respiratory diseases; Science; Science (multidisciplinary); Signaling; Transcription; Viruses; Middle East; Saudi Arabia

Middle East respiratory syndrome coronavirus (MERS-CoV) is enzootic in dromedary camels across the Middle East and Africa. Virus-induced pneumonia in humans results from animal contact, with a potential for limited onward transmission. Phenotypic changes have been suspected after a novel recombinant...