Social preference is maintained in mice with impaired startle reflex and glutamate/D-serine imbalance induced by chronic cerebral toxoplasmosis

• Published in: Scientific reports Vol. 11; no. 1; p. 14029
• Main Authors: Acquarone, Mariana, Poleto, A., Perozzo, A. F., Gonçalves, P. F. R., Panizzutti, R., Menezes, J. R. L., Neves, G. A., Barbosa, Helene Santos
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.07.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378; 631/378/2649; 692/420; 692/420/254; 692/699; 692/699/476; Bipolar disorder; Central nervous system; Chronic infection; Cognitive ability; Cysts; D-Serine; Dopamine; Etiology; Geographical distribution; Glutamatergic transmission; Hippocampus; Humanities and Social Sciences; Mental disorders; multidisciplinary; Nervous system; Neurological diseases; Neurotransmission; Opportunist infection; Pathogens; Protozoa; Risk factors; Schizophrenia; Science; Science (multidisciplinary); Spontaneous alternation; Startle response; Toxoplasmosis; Tropism

Toxoplasma gondii is an opportunistic protozoan pathogen with a wide geographic distribution. The chronic phase of toxoplasmosis is often asymptomatic in humans and is characterized by tissue cysts throughout the central nervous system and muscle cells. T. gondii and other pathogens with tropism for...